Alterations of Glucoregulation in Childhood Obesity - Association with Insulin Resistance and Hyperinsulinemia

Felszeghy, Enikő; Juhász, É.; Káposzta, Rita; Ilyés, István

doi:10.1515/jpem.2008.21.9.847

Cited by 15 publications

(8 citation statements)

References 8 publications

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“…Using fasting insulin alone yielded similar results as using HOMA-IR when relationships with cardiovascular risk factors were examined in our study. Previous studies have shown that hyperinsulinaemia is associated with cardiovascular risk factors1 and it can initially compensate well for insulin resistance in obese children2. Libman et al .…”

Section: Discussionmentioning

confidence: 99%

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Determinants of High Fasting Insulin and Insulin Resistance Among Overweight/Obese Adolescents

Ling

Mohamed

Jalaludin

et al. 2016

Sci Rep

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Hyperinsulinaemia is the earliest subclinical metabolic abnormality, which precedes insulin resistance in obese children. An investigation was conducted on the potential predictors of fasting insulin and insulin resistance among overweight/obese adolescents in a developing Asian country. A total of 173 overweight/obese (BMI > 85th percentile) multi-ethnic Malaysian adolescents aged 13 were recruited from 23 randomly selected schools in this cross-sectional study. Waist circumference (WC), body fat percentage (BF%), physical fitness score (PFS), fasting glucose and fasting insulin were measured. Insulin resistance was calculated using homeostasis model assessment of insulin resistance (HOMA-IR). Adjusted stepwise multiple regression analysis was performed to predict fasting insulin and HOMA-IR. Covariates included pubertal stage, socioeconomic status, nutritional and physical activity scores. One-third of our adolescents were insulin resistant, with girls having significantly higher fasting insulin and HOMA-IR than boys. Gender, pubertal stage, BMI, WC and BF% had significant, positive moderate correlations with fasting insulin and HOMA-IR while PFS was inversely correlated (p < 0.05). Fasting insulin was primarily predicted by gender-girls (Beta = 0.305, p < 0.0001), higher BMI (Beta = −0.254, p = 0.02) and greater WC (Beta = 0.242, p = 0.03). This study demonstrated that gender, BMI and WC are simple predictors of fasting insulin and insulin resistance in overweight/obese adolescents.

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Section: Discussionmentioning

confidence: 99%

“…In obese children, hyperinsulinaemia can initially compensate well for insulin resistance2. However, chronic obesity may persistently impair insulin-mediated glucose metabolism3.…”

mentioning

confidence: 99%

Determinants of High Fasting Insulin and Insulin Resistance Among Overweight/Obese Adolescents

Ling

Mohamed

Jalaludin

et al. 2016

Sci Rep

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“…Population-based data documented that the epidemic of obesity has been followed by an epidemic of type 2 diabetes mellitus and impaired glucose tolerance (IGT) as observed both in adulthood and childhood (14,15) . Obesity is associated with insulin resistance and systemic low-grade infl ammation even in childhood (16,17) .…”

Section: Introductionmentioning

confidence: 99%

PPAR-γ2 Pro12Ala polymorphism is associated with post-challenge abnormalities of glucose homeostasis in children and adolescents with obesity

Jermendy

Körner

Kovács

et al. 2011

Journal of Pediatric Endocrinology and Metabolism

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The association between PPAR-gamma2 Prol2Ala polymorphism and glucose metabolism is already present in children and adolescents with obesity who might be at the very beginning of the natural course of type 2 diabetes. At this stage, higher insulin sensitivity can be detected in Ala allele carriers compared to homozygous Pro subjects at post-challenge but not in fasting state; however, the TNF-system seems not to be involved in the alteration of glucose homeostasis due to PPAR-gamma2 Pro12Ala polymorphism.

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“…The requirement of an accurate diagnosis of MS is increasing and in this regard, fasting blood glucose levels, which are less sensitive for detecting insulin resistance and deterioration in glucose metabolism than serum insulin levels or oral glucose tolerance tests, may limit early diagnosis of the syndrome 6) . Obesity is associated with a high incidence of abnormal serum levels of glutamic pyruvic transaminase (GPT).…”

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confidence: 99%

Usefulness of GPT for Diagnosis of Metabolic Syndrome in Obese Japanese Children

Abe

Kikuchi

Nagasaki

et al. 2009

JAT

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Aim:The aim of this study was to evaluate the usefulness of glutamate pyruvate transaminase (GPT) levels in the diagnosis of metabolic syndrome (MS) in obese Japanese children. Methods: We examined 193 obese boys (mean age: 12.1 yrs; mean percent overweight [POW]: 53.9%) and 37 obese girls (mean age: 11.4 yrs; mean POW: 57.2%). Anthropometric measurements, blood pressure and levels of liver transaminases, serum lipids and lipoproteins, fasting blood glucose (FBG), serum insulin and adiponectin were measured. The subjects were divided into either an MS or a non-MS group according to the MS definition criteria for Japanese children. Results: The level of GPT was significantly higher in the MS group in both genders. Correlation analysis revealed positive correlations between GPT and waist circumference, blood pressure, maximum preperitoneal fat thickness, serum insulin and homeostasis model assessment-insulin resistance (HOMA-R), but no correlation between GPT and FBG. ANOVA showed a significant difference in GPT levels between MS and non-MS subgroups, whereas there was no difference in FBG between the two groups. Receiver operating characteristic curves demonstrated that GPT was clearly superior to FBG as a diagnostic marker of MS. Conclusion: We conclude that an elevation in GPT in obese children most likely reflects insulin resistance and that GPT is superior to FBG as a marker of MS.

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Alterations of Glucoregulation in Childhood Obesity - Association with Insulin Resistance and Hyperinsulinemia

Abstract: Our data show that hyperinsulinemia can successfully compensate for insulin resistance in the majority of the obese children. Since IFG is less frequent than IGT there is a need for performing OGTT to demonstrate abnormality of glucoregulation in obese children.

Cited by 15 publications

References 8 publications

Determinants of High Fasting Insulin and Insulin Resistance Among Overweight/Obese Adolescents

Determinants of High Fasting Insulin and Insulin Resistance Among Overweight/Obese Adolescents

PPAR-γ2 Pro12Ala polymorphism is associated with post-challenge abnormalities of glucose homeostasis in children and adolescents with obesity

Usefulness of GPT for Diagnosis of Metabolic Syndrome in Obese Japanese Children

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