Alterations in the Plasma and Red Blood Cell Properties in Patients with Varicose Vein: A Pilot Study

Gwoździński, Łukasz; Pieniążek, Anna; Bernasińska-Słomczewska, Joanna; Hikisz, Paweł; Gwoździński, Krzysztof

doi:10.1155/2021/5569961

Cited by 6 publications

(6 citation statements)

References 70 publications

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“…Leukocytosis is seen in patients with varicose veins and is an indicator of persistent inflammation with an increase in tissue hypoxia and a further increase in the hypoxia inducer factor to stimulate erythropoietin production and an additional increase in the RBC level of red blood cells in patients with varicose veins [32,33]. This persistent inflammation is confirmed by the elevation of the ESR level in patients with varicose veins [34][35][36][37].…”

Section: Discussionmentioning

confidence: 92%

Single Cross-Sectional Analysis; Post-Myocardial Infarction Instrumental & Laboratory changes in Prognosis Behavior

Marzoog

Bloshkina

Gromova

et al. 2023

Preprint

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Background: Cardiovascular events remain one of the frequently reported causes of death globally. Aims: Assess the early laboratory and instrumental changes in systemic manner. Objectives: Patients with fresh myocardial infarction that has been occurred in less than 30 days before hospitalization in the rehabilitation hospital. Materials and methods: A single large scale retrospective cohort sectional study for patient with fresh myocardial infarction for the period of 2014-2019, data collected from Mordovia Rehabilitation Hospital. The study involved 154 patients and analyzed 76 parameters for each patient. The t-test, Pearson correlation coefficient, and ROC test has been used. For statistical analysis used Statistica program. Results: The sample included 154 patients with history of fresh myocardial infarction. Of 154. 51(33.11%) female and 103 (66.88 %) males. chronic heart failure (CHF), which is seen in 42 (27.27273 %) patients, 101 (65.58442 %) did not have a CHF, and 11 (7.14286 %) missing data. Diabetes mellitus (DM) has been observed in 28 (18.18182 %), 118 (76.62338 %) without DM, Hypertension has been seen in 118 (76.62338 %), 28 (18.18182%) did not have hypertension, chronic kidney disease (CKD) has been seen in 11 (7.14%) patients, 131 (85.06494 %) did not have CKD, Chronic obstructive pulmonary disease (COPD) existed in 14 (9.09091%), 132 (85.71429 %) did not have COPD. Post myocardial infarction (MI) CHF has been seen in 108 (70.12987%), 42 (27.27273 %) did not have CHF. Post MI arrythmia seen in 50 (32.47%) patients, 99 (64.28571%) did not have arrythmia. Early post MI complication such as aneurysm has been seen in 12 (7.79221%), 138 (89.61039 %) did not have aneurysm, Dressler syndrome; pericarditis has been seen in 4 (2.59740%) patients, pneumonitis seen in 1 (0.64935%) patient, and pleuritis have not been seen. Conclusions: Systemic manifestations include kidney function impairment or development of new kidney disease. Of these changes include increase in the aorta basement diameter, increase in the right ventricle wall thickness, decrease in the level of serum red blood cell, serum potassium level, and serum calcium level, with increase in the serum myoglobulin. Others: Females are more frequently affected with post MI urinary tract infection.

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Section: Discussionmentioning

confidence: 92%

Single Cross-Sectional Analysis; Post-Myocardial Infarction Instrumental & Laboratory changes in Prognosis Behavior

Marzoog

Bloshkina

Gromova

et al. 2023

Preprint

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“…These changes were accompanied by a decrease in the activity of catalase (CAT) and acetylcholinesterase (AChE). We observed a decrease in the level of thiols in plasma, hemolysate, and plasma membranes, and an increase in parameters related to oxidative stress, such as the level of protein carbonyl compounds and the level of thiobarbituric acid reactive substances (TBARS) in varicose veins [ 85 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Diosmin, Escin, and Bromelain on Human Endothelial Cells Derived from the Umbilical Vein and the Varicose Vein—A Preliminary Study

Gwoździński

Bernasińska-Słomczewska

Hikisz

et al. 2023

Biomedicines

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In this study, we investigated the properties of human varicose vein (VV) endothelial cells (HVVEC) in comparison to the human umbilical vein endothelial cells (HUVEC). The cells were treated with three bioactive compounds with proven beneficial effects in the therapy of patients with VV, diosmin, escin, and bromelain. Two concentrations of tested drugs were used (1, 10 mg/mL), which did not affect the viability of either cell type. Escin led to a slight generation of reactive oxygen species in HUVEC cells. We observed a slight release of superoxide in HVVEC cells upon treatment with diosmin and escin. Diosmin and bromelain showed a tendency to release nitric oxide in HUVEC. Using membrane fluorescent probes, we demonstrated a reduced fluidity of HVVEC, which may lead to their increased adhesion, and, consequently, a much more frequent occurrence of venous thrombosis. For the first time, we show the mechanism of action of drugs used in VV therapy on endothelial cells derived from a VV. Studies with HVVEC have shown that tested drugs may lead to a reduction in the adhesive properties of these cells, and thus to a lower risk of thrombosis.

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“…An increase in the level of oxidative stress parameters in plasma, e.g., TBARS, and protein carbonyls, as well as decreased catalase activity and thiol levels, were also observed in a group of patients with varicose veins compared to a group of healthy volunteers [151,152]. Oxidative damage to proteins and lipids was accompanied by a decrease in the level of thiols, a decrease in the level of non-enzymatic antioxidant capacity (NEAC), as well as a decrease in catalase, and acetylcholinesterase (AChE) activities in plasma derived from varicose veins [144]. It has been shown that the decrease in CAT activity can be initiated by hydroxyl radicals, superoxide, and H 2 O 2 , but not by organic peroxides [153,154].…”

Section: Antioxidants and Oxidative Stress In Plasma And Red Blood Ce...mentioning

confidence: 92%

“…We demonstrated that hemoglobin modified by ROS or bound to the plasma membrane is present in erythrocytes from the varicose vein [144]. It has been shown that irreversible oxidation of this cysteine residue, βCys93, in the globin chain may lead to the breakdown of the Hb structure and, consequently, the release of heme [145].…”

Section: Alterations In Red Blood Cells Properties In Cvedmentioning

confidence: 92%

“…To demonstrate the role of oxidative stress in the blood of varicose veins, we compared markers of oxidative stress in plasma and red blood cells taken from varicose veins and the cubital vein of the same patients. In plasma from varicose veins, we found lipid and protein peroxidation products, as indicated by higher levels of a thiobarbituric acid reactive substance (TBARS) and protein carbonyl compounds, as well as by a decrease in thiol compounds [144]. Glutathione and thiols present in red blood cells perform an important role in protecting lipids, proteins, and other macromolecules against oxidative damage.…”

Section: Antioxidants and Oxidative Stress In Plasma And Red Blood Ce...mentioning

confidence: 93%

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Factors Influencing Venous Remodeling in the Development of Varicose Veins of the Lower Limbs

Gwozdzinski,

Pieniazek,

Gwozdzinski

2024

IJMS

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One of the early symptoms of chronic venous disease (CVD) is varicose veins (VV) of the lower limbs. There are many etiological environmental factors influencing the development of chronic venous insufficiency (CVI), although genetic factors and family history of the disease play a key role. All these factors induce changes in the hemodynamic in the venous system of the lower limbs leading to blood stasis, hypoxia, inflammation, oxidative stress, proteolytic activity of matrix metalloproteinases (MMPs), changes in microcirculation and, consequently, the remodeling of the venous wall. The aim of this review is to present current knowledge on CVD, including the pathophysiology and mechanisms related to vein wall remodeling. Particular emphasis has been placed on describing the role of inflammation and oxidative stress and the involvement of extracellular hemoglobin as pathogenetic factors of VV. Additionally, active substances used in the treatment of VV were discussed.

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Alterations in the Plasma and Red Blood Cell Properties in Patients with Varicose Vein: A Pilot Study

Cited by 6 publications

References 70 publications

Single Cross-Sectional Analysis; Post-Myocardial Infarction Instrumental & Laboratory changes in Prognosis Behavior

Single Cross-Sectional Analysis; Post-Myocardial Infarction Instrumental & Laboratory changes in Prognosis Behavior

The Effect of Diosmin, Escin, and Bromelain on Human Endothelial Cells Derived from the Umbilical Vein and the Varicose Vein—A Preliminary Study

Factors Influencing Venous Remodeling in the Development of Varicose Veins of the Lower Limbs

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