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Cited by 22 publications
(32 citation statements)
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“…14,15 As with patients with mTLE, shifting of functional brain network patterns has been observed in different animal models of this disorder. [15][16][17] A significant increase in functional connectivity was observed in the kainic acid (KA)induced TLE model. 15 A widespread hyposynchrony of brain network patterns has also been linked to the progression of epileptogenesis.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…14,15 As with patients with mTLE, shifting of functional brain network patterns has been observed in different animal models of this disorder. [15][16][17] A significant increase in functional connectivity was observed in the kainic acid (KA)induced TLE model. 15 A widespread hyposynchrony of brain network patterns has also been linked to the progression of epileptogenesis.…”
Section: Introductionmentioning
confidence: 99%
“…17 A recent study indicated that a dynamic mechanism is responsible for altered resting-state functional brain networks in epilepsy: a shift of global and local excitability that supports the combination of hyper-and hypoconnectivity in the epileptic brain. 18 Although animal studies have identified brain network abnormalities related to epilepsy, [15][16][17]19 our understanding of brain network changes in animals that do not develop epilepsy, or so-called "lesioned controls," is limited. Compared to the healthy brain, epileptogenic network formation is considered to be associated with a series of insult-related compensations, leading to a disease-related, maladaptive plasticity.…”
Section: Introductionmentioning
confidence: 99%
“…Functional connectivity abnormalities related to seizure disorders have been investigated with resting state fMRI (rsfMRI) (Christiaen et al., 2019; Grassia et al., 2018; Liao et al., 2010; Morgan et al., 2019; Zhang et al., 2018, 2019). The majority of these studies have been conducted among patients with mesial temporal lobe epilepsy (MTLE).…”
Section: Discussionmentioning
confidence: 99%
“…While resting state connectivity disturbances have been investigated and identified in both generalized and focal epilepsy (Bernhardt et al., 2013; Christiaen et al., 2019; Englot et al., 2016; Grassia et al., 2018; Liao et al., 2010; Moeller et al., 2011; Pittau et al., 2012), no studies to date have specifically focused on drug resistant CCM-related epilepsy. Here, we study the impact of CCM-associated epilepsy on functional connectivity by analyzing rsfMRI data acquired from subjects before and after surgical resection of the epilepsy focus.…”
Section: Introductionmentioning
confidence: 99%
“…SE has a 20–40% mortality rate and a 30% rate of neurological deficits [ 1 ]. SE leads to neuronal injury, alterations of neuronal networks, brain edema, and neuroinflammation, which cause various neurological complications, such as epilepsy and cognitive impairments [ 2 , 3 , 4 ]. SE also rapidly evokes reactive astrogliosis and astroglial apoptosis in regional specific manners independent of hemodynamics [ 5 , 6 , 7 , 8 , 9 , 10 ].…”
Section: Introductionmentioning
confidence: 99%