2016
DOI: 10.18632/aging.100875
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Abstract: Aged testes undergo profound histological and morphological alterations leading to a reduced functionality. Here, we investigated whether variations in longevity affect the development of local inflammatory processes, the oxidative state and the occurrence of apoptotic events in the testis. To this aim, well-established mouse models with delayed (growth hormone releasing hormone-knockout and Ames dwarf mice) or accelerated (growth hormone-transgenic mice) aging were used.We hereby show that the testes of short… Show more

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Cited by 31 publications
(22 citation statements)
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References 60 publications
(80 reference statements)
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“…Studies on humans have also reported that comorbidities and obesity strongly contribute to late-onset hypogonadism ( Basaria, 2013 ). This concurs with the results of this study, in the sense that patients with NAFLD have a shorter life expectancy and a systematic inflammatory state ( Matzkin et al, 2016 ), accompanied with accelerated testicular damage. This suggests that testicular damage is more related to the state of health of the liver and/or systemic inflammation, than to patient age.…”
Section: Discussionsupporting
confidence: 92%
“…Studies on humans have also reported that comorbidities and obesity strongly contribute to late-onset hypogonadism ( Basaria, 2013 ). This concurs with the results of this study, in the sense that patients with NAFLD have a shorter life expectancy and a systematic inflammatory state ( Matzkin et al, 2016 ), accompanied with accelerated testicular damage. This suggests that testicular damage is more related to the state of health of the liver and/or systemic inflammation, than to patient age.…”
Section: Discussionsupporting
confidence: 92%
“…With aging, the enzymatic defense mechanisms protecting the germinal epithelium cannot cope with the extensive oxidative damage and therefore apoptotic events increases especially in germ cells. Thus, aged testes undergo profound histological and morphological alterations leading to a reduction in testicular function [26].…”
Section: Discussionmentioning
confidence: 99%
“…This leads to the increased expression of inflammatory target proteins such as matrix metalloproteinase-9 (MMP9), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and cytosolic phospholipase A2 (cPLA2) and proinflammatory mediators such as the TNF- α , IL-1, and IL-6. Many of these inflammatory proteins or their products such as iNOS, COX, and PGE2 are prominent sources of ROS [ 96 99 ]. In fact, the presence of these inflammatory biomarkers in aging is related to the endothelial damage, vascular smooth muscle cell (VSMC) proliferation, and matrix remodelling, being associated to the genesis and progression of cardiovascular diseases, such as atherosclerosis and hypertension [ 100 102 ].…”
Section: Inflammation: a War Without An Armymentioning
confidence: 99%