Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats

Up-regulation of Functionally Impaired Insulin-like Growth Factor-1 Receptor in Scrapie-infected Neuroblastoma Cells

“…Changes in the IGF-1 system has been reported in various brain insults (2) and evidence indicates that IGF-1R mRNA is up-regulated as a function of aging and cognitive deficits (23,55), consistent with a neuroplastic role of the IGF-1R under degenerative conditions. However, functional impairment of the IGF-1R was also reported in several regions of the pathologically aging brain as demonstrated by decreased 125 I-IGF-1-binding and IGF-1-stimulated protein synthesis, despite unchanged mRNA levels (55,56). Thus the up-regulation of the IGF-1R may be an attempt by the affected neurons to increase the trophic support, however, unsuccessful because of defective receptor binding and/or signaling.…”

Insulin-like Growth Factor 1-mediated Hyperthermia Involves Anterior Hypothalamic Insulin Receptors

“…The IGF-1R is widely expressed in many tissues (17)(18)(19)(20), including the hypothalamus (17,(21)(22)(23) and notably within the preoptic area (POA) (17). Insulin receptors are also expressed in several regions of the hypothalamus, including the arcuate nucleus and the POA (24 -26).…”

Neurobiology of cognitive aging: Insights from imaging genetics

“…15q26.3 Insulin-like growht factor-a (IGF-1) and type 1 IGF receptor play an important role in neuronal development and function. A genetic variation of this protein has been linked to longevity in humans (Bonafe et al, 2003) and to cognitive function in rats (Sonntag et al, 1999 (Licastro, Porcellini, Caruso, Lio, & Corder, 2007).…”