Alterations in GABAergic function following forced swimming stress

Briones-Aranda, Alfredo; Rocha, Luísa; Picazo, Ofir Picazo

doi:10.1016/j.pbb.2005.01.002

Cited by 30 publications

(16 citation statements)

References 60 publications

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“…The GABA concentration also may be dynamically modulated by stress or emotion, however, because it was observed in animals that stress reduced total brain GABA levels. 48,49 The reduction in GABA concentrations found herein in the depressed sample thus may reflect a neurochemical correlate of their emotional and stressed state. Because extracellular GABA is regulated by intracellular GABA concentration, 50 a reduced MRS-determined GABA concentration most likely correlates with reduced extracellular GABA, less GABAergic inhibition, and possibly increased glutamatergic excitotoxicity.…”

Section: Commentmentioning

confidence: 77%

Reduced Prefrontal Glutamate/Glutamine and γ-Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy

Hasler¹,

Veen²,

Tumonis³

et al. 2007

Arch Gen Psychiatry

768

502

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Context: Increasing evidence indicates that major depressive disorder (MDD) is associated with altered function of the major excitatory and inhibitory neurotransmitters glutamate and ␥-aminobutyric acid (GABA), respectively. A recently developed magnetic resonance spectroscopy method allows for reliable measurement of glutamate/glutamine (Glx) and GABA concentrations in prefrontal brain regions that have been implicated in the pathophysiologic mechanisms of MDD by studies using other neuroimaging and postmortem techniques.Objective: To measure Glx and GABA levels in 2 regions of the prefrontal brain tissue in unmedicated adults with MDD.Design: Cross-sectional study for association.Setting: Psychiatric outpatient clinic.Participants: Twenty unmedicated, depressed patients with MDD and 20 age-and sex-matched controls.Intervention: Participants underwent scanning using a 3-T whole-body scanner with a transmit-receive head coil, providing a homogeneous radiofrequency field and the capability of obtaining spectroscopic measurements in a dorsomedial/dorsal anterolateral prefrontal region of interest (ROI) and a ventromedial prefrontal ROI. Main Outcome Measures:Glx and GABA levels derived from magnetic resonance spectroscopy signals.Results: Depressed patients had reduced Glx levels in both ROIs. The GABA levels were reduced in the dorsomedial/dorsal anterolateral prefrontal ROI. Levels of GABA and Glx were positively correlated in both ROIs. Conclusions:For the first time, GABA and Glx concentrations were compared between unmedicated depressed adults and controls in prefrontal ROIs. The abnormal reductions in Glx and GABA concentrations found in the MDD sample were compatible with findings from postmortem histopathologic studies, indicating that glial cell density is reduced in the same areas in MDD.

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Section: Commentmentioning

confidence: 77%

Reduced Prefrontal Glutamate/Glutamine and γ-Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy

Hasler¹,

Veen²,

Tumonis³

et al. 2007

Arch Gen Psychiatry

768

502

View full text Add to dashboard Cite

show abstract

“…Although depression is seen largely as a dysfunction in monoamine neurotransmission and all antidepressant strategies focus largely on monoamines, strong clinical and preclinical evidence implicates dysfunction of the GABAergic system in depression (Krystal et al, 2002). In rodents, the amygdala has been shown to be involved in depressive-like behavior in the FST, at least in part through GABA release (Ebner et al, 2005;Briones-Aranda et al, 2005). Different studies described antidepressant effects of the GABAb receptor agonist baclofen in FST (Cryan and Kaupmann, 2005), conceivably through presynaptic GABAb receptor activation leading to decrease of GABA release (Rea et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Prefrontal/Amygdalar System Determines Stress Coping Behavior Through 5-HT/GABA Connection

Andolina

Maran

Valzania

et al. 2013

Neuropsychopharmacol

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Coping is defined as the behavioral and physiological effort made to master stressful situations. The ability to cope with stress leads either to healthy or to pathogenic outcomes. The medial prefrontal cortex (mpFC) and amygdala are acknowledged as having a major role in stress-related behaviors, and mpFC has a critical role in the regulation of amygdala-mediated arousal in response to emotionally salient stimuli. Prefrontal cortical serotonin (5-hydroxytryptamine (5-HT)) is involved in corticolimbic circuitry, and GABA has a major role in amygdala functioning. Here, using mice, it was assessed whether amygdalar GABA regulation by prefrontal 5-HT is involved in processing stressful experiences and in determining coping outcomes. First (experiment 1), bilateral selective 5-HT depletion in mpFC of mice reduced GABA release induced by stress in basolateral amygdala (BLA) and passive coping in the Forced Swimming Test (FST) (experiment 2). Moreover, prefrontal-amygdala disconnection procedure that combined a selective unilateral 5-HT depletion of mpFC and infusion of an inhibitor of GABA synthesis into the contralateral BLA, thereby to disrupt prefrontal-amygdalar serial connectivity bilaterally, showed that disconnection selectively decreases immobility in the FST. These results point to prefrontal/amygdala connectivity mediated by 5-HT and GABA transmission as a critical neural mechanism in stress-induced behavior.

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“…Decreased GABA release in hippocampus in LH model [Petty and Sherman, 1981;Shiah and Yatham, 1998] and in cortex, hippocampus, nucleus accumbens and brainstem in FST in rats and mice [Borsini et al, 1988;Gomez et al, 2003;Briones-Aranda et al, 2005]. Increased brain GABA-A receptor density in OB and LH models in rats [Dennis et al, 1984;Kram et al, 2000].…”

Section: Animal Models Of Anxiety and Depressionmentioning

confidence: 99%

“…Reduced benzodiazepine binding in amygdala 24 h after FST in mice [Briones-Aranda et al, 2005]. Reduced allopregnanolone levels in amygdala in the olfactobulbectomy model of depression in rats [Uzunova et al, 2003].…”

Section: Brain Circuits Of Anxiety and Depressionmentioning

confidence: 99%

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Role of GABA in anxiety and depression

2007

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This review assesses the parallel data on the role of gamma-aminobutyric acid (GABA) in depression and anxiety. We review historical and new data from both animal and human experimentation which have helped define the key role for this transmitter in both these mental pathologies. By exploring the overlap in these conditions in terms of GABAergic neurochemistry, neurogenetics, brain circuitry, and pharmacology, we develop a theory that the two conditions are intrinsically interrelated. The role of GABAergic agents in demonstrating this interrelationship and in pointing the way to future research is discussed.

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Alterations in GABAergic function following forced swimming stress

Cited by 30 publications

References 60 publications

Reduced Prefrontal Glutamate/Glutamine and γ-Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy

Reduced Prefrontal Glutamate/Glutamine and γ-Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy

Prefrontal/Amygdalar System Determines Stress Coping Behavior Through 5-HT/GABA Connection

Role of GABA in anxiety and depression

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