Alterations in Brain Phosphate Metabolite Concentrations in Patients With Human Immunodeficiency Virus Infection

Abstract

Phil (Oxon) res, rkshops minofC ;ia, k Eisen, Sumner, .y course nd 122 me 21. ting lospitat 021 14 or

Metabolic Reprogramming in HIV-Associated Neurocognitive Disorders

“…We also discovered that the addition of Tepp-46 could return ATP levels to that of control cells even in the presence of gp120 ( Figure 7E ). This reduction in ATP would correlate with the previously seen reduction of ATP in the brains of people living with HIV using magnetic resonance spectroscopy (MRS) ( Deicken et al, 1991 ). In addition, it has been shown that the addition of Tepp-46 can increase ATP production by returning enzyme activity to PKM2, resulting in increased pyruvate production to be used in the TCA cycle and to fuel OXPHOS ( Qi et al, 2017 ).…”

Metabolic Reprogramming in HIV-Associated Neurocognitive Disorders

“…We also discovered that the addition of Tepp-46 could return ATP levels to that of control cells even in the presence of gp120 ( Figure 7E ). This reduction in ATP would correlate with the previously seen reduction of ATP in the brains of people living with HIV using magnetic resonance spectroscopy (MRS) ( Deicken et al, 1991 ). In addition, it has been shown that the addition of Tepp-46 can increase ATP production by returning enzyme activity to PKM2, resulting in increased pyruvate production to be used in the TCA cycle and to fuel OXPHOS ( Qi et al, 2017 ).…”

Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats

“…Peroxisome dysfunction may also contribute to increased lipid peroxidation and cellular aging in HIV-1 [90,91]. In apparent agreement with the dysregulation of these pathways, evidence suggestive of altered phospholipid metabolism has been reported in HIV-1 patients [92,93] and peroxisome dysregulation can be indicative of altered brain oxidative balance associated with HIV-1 [94]. …”

A 31phosphorous magnetic resonance spectroscopy study of diazepam does not affect brain phosphorous metabolism

“…Absolute molar concentrations were estimateA as previously described (Roth et al 19~? ;L~wry et al 1989;Deicken et al 1991).…”

Metabolic Reprogramming in HIV-Associated Neurocognitive Disorders

“…We also discovered that the addition of Tepp-46 could return ATP levels to that of control cells even in the presence of gp120 ( Figure 7E ). This reduction in ATP would correlate with the previously seen reduction of ATP in the brains of people living with HIV using magnetic resonance spectroscopy (MRS) ( Deicken et al, 1991 ). In addition, it has been shown that the addition of Tepp-46 can increase ATP production by returning enzyme activity to PKM2, resulting in increased pyruvate production to be used in the TCA cycle and to fuel OXPHOS ( Qi et al, 2017 ).…”

Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats

“…Peroxisome dysfunction may also contribute to increased lipid peroxidation and cellular aging in HIV-1 [90,91]. In apparent agreement with the dysregulation of these pathways, evidence suggestive of altered phospholipid metabolism has been reported in HIV-1 patients [92,93] and peroxisome dysregulation can be indicative of altered brain oxidative balance associated with HIV-1 [94]. …”

A 31phosphorous magnetic resonance spectroscopy study of diazepam does not affect brain phosphorous metabolism

“…Absolute molar concentrations were estimateA as previously described (Roth et al 19~? ;L~wry et al 1989;Deicken et al 1991).…”

Metabolic Reprogramming in HIV-Associated Neurocognitive Disorders

“…We also discovered that the addition of Tepp-46 could return ATP levels to that of control cells even in the presence of gp120 ( Figure 7E ). This reduction in ATP would correlate with the previously seen reduction of ATP in the brains of people living with HIV using magnetic resonance spectroscopy (MRS) ( Deicken et al, 1991 ). In addition, it has been shown that the addition of Tepp-46 can increase ATP production by returning enzyme activity to PKM2, resulting in increased pyruvate production to be used in the TCA cycle and to fuel OXPHOS ( Qi et al, 2017 ).…”

Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats

“…Peroxisome dysfunction may also contribute to increased lipid peroxidation and cellular aging in HIV-1 [90,91]. In apparent agreement with the dysregulation of these pathways, evidence suggestive of altered phospholipid metabolism has been reported in HIV-1 patients [92,93] and peroxisome dysregulation can be indicative of altered brain oxidative balance associated with HIV-1 [94]. …”

A 31phosphorous magnetic resonance spectroscopy study of diazepam does not affect brain phosphorous metabolism

“…Absolute molar concentrations were estimateA as previously described (Roth et al 19~? ;L~wry et al 1989;Deicken et al 1991).…”