2008
DOI: 10.1111/j.1432-0436.2007.00226.x
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Alteration of medial-edge epithelium cell adhesion in two Tgf-β3 null mouse strains

Abstract: Although palatal shelf adhesion is a crucial event during palate development, little work has been carried out to determine which molecules are responsible for this process. Furthermore, whether altered palatal shelf adhesion causes the cleft palate presented by Tgf-b 3 null mutant mice has not yet been clarified. Here, we study the presence/distribution of some extracellular matrix and cell adhesion molecules at the time of the contact of palatal shelves in both wild-type and Tgf-b 3 null mutant palates of tw… Show more

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Cited by 31 publications
(52 citation statements)
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“…E-cadherin and integrins play important roles in the process of palatal adhesion (Frebourg et al, 2006, Martinez-Sanz et al, 2008, Munger and Sheppard, 2011. To investigate the involvement of SFK in E-cadherin-and integrin-mediated palatal adhesion, double immunofluorescence labeling was performed.…”
Section: Discussionmentioning
confidence: 99%
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“…E-cadherin and integrins play important roles in the process of palatal adhesion (Frebourg et al, 2006, Martinez-Sanz et al, 2008, Munger and Sheppard, 2011. To investigate the involvement of SFK in E-cadherin-and integrin-mediated palatal adhesion, double immunofluorescence labeling was performed.…”
Section: Discussionmentioning
confidence: 99%
“…Deletion of integrin aV resulted in the lack of aVb1, aVb3, aVb5, aVb6, and aVb8 integrins and was linked to a cleft palate phenotype (Munger and Sheppard, 2011). Anti-integrin a5 blocking antibody caused significant reduction in the adhesion of palatal shelves up to 70% (Martinez-Sanz et al, 2008). Enzymatic digestion of chondroitin sulphate proteoglycan which interacts with integrins to mediate signals led to the inhibition of palatal adhesion (Gato et al, 2002).…”
Section: Introductionmentioning
confidence: 99%
“…Once palatal shelves have approached their medial edges, opposing MEE adhesion takes place, which is ensured by the presence of extracellular matrix and cell adhesion molecules such as nectin-1, fibronectin, integrin-␣ 5, chondroitin and heparan sulfate proteoglycans, and alterations in their patterns of expression compromise palatal-shelf adhesion and fusion [Gato et al, 2002;Martínez-Sanz et al, 2008]. We found a significant reduction in palatal-shelf adhesion in palate cultures of embryos of dams fed the FAD diet for 2 weeks, which suggests that molecules that are relevant for opposing MEE adhesion were altered in these palates.…”
Section: Discussionmentioning
confidence: 99%
“…Experiments using Tgf-␤ 3 null mutant ( Tgf-␤ 3 -/-) mice demonstrated that SMAD2, but not SMAD3, is phosphorylated upon activation of TGF-␤ receptors and mediates most of the mechanisms causing palatal fusion [Cui et al, 2003[Cui et al, , 2005Shiomi et al, 2006]. All Tgf-␤ 3 -/-mice bear CPs [Kaartinen et al, 1995;Proetzel et al, 1995;Resel et al, 2007] and, regarding the wild type, approaching Tgf-␤ 3 -/-palatal shelves show altered cell proliferation in both the MEE and the mesenchyme [Cui et al, 2003;Xu et al, 2006;Del Río et al, 2010] and an anomalous presence or localization of cell adhesion and extracellular matrix molecules on the MEE apical surface [Gato et al, 2002;Tudela et al, 2002;Martínez-Sanz et al, 2008]. This causes failure of palatal-shelf adhesion [Gato et al, 2002], opposing MEE cell intercalation and transformation into mesenchyme [Kaartinen et al, 1997].…”
mentioning
confidence: 99%
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