Alteration of Ischemia Modified Albumin and Nitric Oxide Levels in Hypothyroidism

Dahiya, Kiran; Verma, Monica; Dhankhar, Rakesh; Singh, Veena; Ps, Ghalaut; Seth, Shashi

doi:10.7754/clin.lab.2013.130432

Cited by 10 publications

(19 citation statements)

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“…It is commonly known as Somakalli and Kodikalli. Sarcostemma brevistigma is an important plant species traditionally used in Indian system of medicine mainly for the treatment of various diseases such as asthma, rheumatisum, arthritis, joints pain, ear ache, dog bite, chronic ulcer, fever, cough, cold, menstural disorder, bone fracture, bronchitis, dysentery, dyspepsia, leprosy, tumor, constipation, skin diseases, ascites and stomach distention [6]. The main objective of the present study is to identify the phytoconstituents of Sarcostemma brevistigma whole plant extract by UV-VIS spectrum and FTIR profile.…”

Section: Introductionmentioning

confidence: 99%

Uv-Visible Spectroscopic and Ftir Analysis of Sarcostemma Brevistigma, Wight. And Arn

Dhivya¹,

Kalaichelvi²

2017

Int J Curr Pharm Sci

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Objective: The present study was carried out to characterize the bioactive constituents present in aerial parts of ethanolic extract of Sarcostemma brevistigma using UV-VIS and FTIR.Methods: FTIR spectroscopy is an established time-saving method to characterize and identify functional groups. Results:The UV-VIS profile showed different peaks ranging from 200-1044 nm with different absorption respectively. UV-VIS profile showed the peaks at 254.00 and 680.00 nm for flavonoid. FTIR spectra showed the peak at 3418.85 cm-1 for N-H group. FTIR analysis and UV-VIS analysis showed the presence of flavonoids and a phenolic compound. The FTIR spectra had amply evidenced the occurrence of OH group together with the Terpenoids, and Phenol. The FT-IR spectrum showed the presence of an amine (N-H), alkyl (C-H), nitrile (C≡N), halo formyl (C=O), alkenyl (C=C), hydroxyl (O-H), haloalkane (C-F), nitrates and carbonate compounds. Conclusion:The results confirm the fact that this plant posse's important bioactive constituent, so further scientific investigation is needed.

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Section: Introductionmentioning

confidence: 99%

Uv-Visible Spectroscopic and Ftir Analysis of Sarcostemma Brevistigma, Wight. And Arn

Dhivya¹,

Kalaichelvi²

2017

Int J Curr Pharm Sci

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“…State of oxidative stress in hypothyroidism itself has been a controversial issue since long. Number of studies have shown increased oxidative stress as exemplified by the increased level of MDA 26,27 or Nitric oxide in hypothyroid subjects 28 or deficient antioxidant defence mechanism in the form of decreased activity of SOD, decreased level of FRAP and GSH. 29 At the same time there are few studies which have shown no elevation of oxidative stress marker in hypothyroid subjects.…”

Section: Discussionmentioning

confidence: 99%

Level of IMA in newly diagnosed untreated hypothyroid subjects diagnosed during routine screening at Tertiary Care Hospital in North India

2020

IJCBR

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Introdcution: Aim of this study was to assess the level of ischemia modified albumin(IMA) in newly diagnosed untreated hypothyroid subjects. Materials and Methods: Serum IMA assessment was done by Barr et al method 30 newly diagnosed patients of hypothyroidism For the control group 50 normal healthy euthyroid adults were selected. TSH was done by one-step sandwich ELISA, and fT3, fT4 was done by one-step competitive ELISA method. Data were presented as mean ± standard deviation (SD). Results: Serum IMA was not found to be statistically different between hypothyroid and euthyroid control group. Conclusion: Contrary to the findings of majority of studies done on this subject, our study has not shown any significant elevation of IMA in hypothyroid subjects as compared to euthyroid subjects. IMA level in subjects of hypothyroidism has been a controversial issue since long. Assessment of cIMA should be done in association with other oxidative stress marker, and their correlation if any should be studied in a large cohort.

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“…Proalbumin, then, gets cleaved in the golgi vesicles to produce the secreted albumin [1]. On virtue of metal binding properties of albumin, metal ions are found to bind to a wide variety of sites, but the commonest one is N-terminus, comprising the sequence N-Asp-Ala-His-Lys [2]. Under ischemic conditions, it has been observed that there is reduced binding to Co 2+ at this terminus and this modified albumin molecule is termed as Ischemia Modified Albumin (IMA).…”

Section: Introductionmentioning

confidence: 99%

Status of Ischemia Modified Albumin in Athletes Before and After Moderate Exercise

Dahiya¹,

Kumar²,

Dhankhar³

et al. 2018

TOBIOMJ

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Background: Ischemia Modified Albumin (IMA) is considered as an early marker of ischemia. Its levels may be altered in any clinical condition where an ischemic event is involved. Skeletal muscle ischemia is associated with severe exercise but may also occur in moderate form of exercise. Objective: The levels of IMA were estimated before and after thirty minutes of moderate exercise in students undergoing athletic training. Methods: The present study was conducted on 120 young adult students undergoing athletic training program in the physical education department. All the subjects were healthy with normal body mass index and blood pressure. Their serum samples were collected before and after running for half an hour on the racing track and were analyzed for IMA colorimetrically and the data was subjected to appropriate statistical analysis. Results: The levels of IMA were found to be statistically significantly higher after exercise as compared to those before exercise (p = 0.005). The ratio of IMA to albumin (IMAR) was also found to be significantly higher after exercise as compared to that before exercise (p=0.000). Conclusion: It may be concluded that the skeletal muscle ischemia induced by moderate aerobic exercise is associated with an increased conversion of albumin to IMA.

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Alteration of Ischemia Modified Albumin and Nitric Oxide Levels in Hypothyroidism

Cited by 10 publications

References 0 publications

Uv-Visible Spectroscopic and Ftir Analysis of Sarcostemma Brevistigma, Wight. And Arn

Uv-Visible Spectroscopic and Ftir Analysis of Sarcostemma Brevistigma, Wight. And Arn

Level of IMA in newly diagnosed untreated hypothyroid subjects diagnosed during routine screening at Tertiary Care Hospital in North India

Status of Ischemia Modified Albumin in Athletes Before and After Moderate Exercise

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