Alteration of hypertrophic scars induced by mechanical pressure

Mechanical Forces Induce Scar Remodeling

“…The disorganized orientation was replaced under pressure by a parallel arrangement similar to the pattern observed in normotrophic healing. This pressure-induced collagen reorganization has been observed previously by Kischer et al 11 In areas treated with pressure, there was a disappearance of nodular pattern. Furthermore, we observed that in hypertrophic scars, collagen fibers perpendicular to the epidermis were anchored in dermal-epidermal zone and probably participated in the impaired mechanical properties of the scar.…”

Local Injection of IFN-gamma Reduces the Number of Myofibroblasts and the Collagen Content in Palatal Wounds

“…Using quantitative techniques, we also found an increased sulfated GAG content at 15 days PW, but a decreased sulfated GAG content in the later stages of scar formation. The latter finding indicates a faster maturation of the scar tissue (Kischer et al, 1975;Shetlar et al, 1979).…”

Cross-sectional evaluation of the prevalence and factors associated with soft tissue scarring after the removal of miniscrews

“…One action may be to provide primary closure of the removal site with sutures or to use pressure garments to inhibit excess proliferation of fibroblasts, protect against irritation, and reduce the scar size as with skin lesions. 20,33,34 Although miniscrew failure per se did not increase the risk of scarring, our study was cross-sectional, and the course of initial healing was not evaluated. Since infection and persistent inflammation after removal the natural course of healing after miniscrew removal and factors influencing initial healing should be further evaluated in the future.…”