Alteration of behavioural changes induced by 3,4,5-trimethoxyphenylethylamine (mescaline) by pretreatment with 2,4,5-trimethoxyphenylethylamine

Dittrich, A.

doi:10.1007/bf00403861

Cited by 11 publications

(8 citation statements)

References 12 publications

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“…Phenylisopropylamines (amphetamines) were used for these experiments because 2,4,5-trisubstituted phenylethylamines containing an alkoxy group in the 4-position are only weakly active in man and other species. For example, a 300 mg oral dose of 2,4,5-trimethoxyphenylethylamine reportedly produced a placebo-like response in a self-experiment (Dittrich, 1971). 2,4,5-Trimethoxyphenylethylamine also has limited behavioral activity in rats (Smythies et al, 1967).…”

Section: Resultsmentioning

confidence: 99%

Comparison of the behavioral effects of mescaline analogs using the head twitch response in mice

et al. 2019

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Section: Resultsmentioning

confidence: 99%

Comparison of the behavioral effects of mescaline analogs using the head twitch response in mice

et al. 2019

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“…Lights were on from 0700 to 1900 hours. The laboratory and animal facility temperature was [22][23][24] °C, and the relative humidity was 40-50%.…”

Section: Methodsmentioning

confidence: 99%

1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: A Potent Serotonin 5-HT2A/2C Agonist

et al. 1994

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A method was found to synthesize 1-(2,5-dimethoxy-4-(trifluoromethyl) phenyl)-2-aminopropane, 5, and its des-alpha-methyl congener 2-(2,5-dimethoxy-4-(trifluoromethyl)phenyl)aminoethane, 6, the trifluoromethyl analogs of substituted hallucinogenic phenethylamine derivatives such as 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (3, DOI) that are potent 5-HT2A/2C agonists. In our hands, 5 and 6 have proven to have affinity for [3H]ketanserin or [125I]-3-labeled 5-HT2A/2C sites in rat cortex comparable to or higher than the analogous bromo or iodo analogs. Similarly, 5 and 6 had potency comparable to or slightly greater than that of their bromo or iodo congeners in the two-lever drug discrimination assay in rats trained to discriminate saline from LSD tartrate. The agonist properties of 5 and 6 were evaluated by measuring the accumulation of [3H]inositol monophosphate in cultured cells selectively expressing either 5-HT2A or 5-HT2C receptors. In comparison to serotonin (5-HT), compounds 3 (DOI), 5, and 6 were equally efficacious and full agonists at the 5-HT2C receptor. Similarly, 3 and 5 produced equivalent responses at the 5-HT2A receptor as compared to 5-HT. In contrast, 6, the alpha-desmethyl analog of 5, was only half as potent at stimulating inositol monophosphate accumulation at the 5-HT2A receptor. In conclusion, the title compound 5 and its alpha-desmethyl congener 6 appear to be the most potent of the so-called hallucinogenic amphetamine 5-HT agonists reported to date. Further, the reduced efficacy of 6 at the 5-HT2A receptor may offer at least a partial explanation for the observed higher in vivo potencies of alpha-methyl-substituted compounds in this series.

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“…Another self-experiment conducted by Dittrich (1971), who used mescaline in combination with 2,4,5-trimethoxyphenethylamine (2C-O). He designed a blind experiment in which he first ingested 300 mg of 2C-O, then 100 mg and 200 mg of 2C-O with mescaline, and finally 250 mg of mescaline alone.…”

Section: Case Reportsmentioning

confidence: 99%

“…Mescaline was shown to decrease performance in a test measuring concentration on optical details, while pretreatment with 2C-O resulted in even greater deterioration of performance than mescaline alone. The time to complete a test (semantic differential) was measured and increased under mescaline compared to placebo and even further after pretreatment with 2C-O (Dittrich, 1971).…”

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confidence: 99%

Drug-drug interactions between classic psychedelics and psychoactive drugs: a systematic review

Halman

Kong

Sarris

et al. 2023

Preprint

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Classic psychedelics, lysergic acid diethylamide, psilocybin, mescaline and N,N-dimethyltryptamine, are potent psychoactive substances that have been studied for their physiological and psychological effects. However, our understanding of the potential interactions and outcomes when these substances are used in combination with other psychoactive drugs is limited. This systematic review aims to provide a comprehensive overview of the current research on drug-drug interactions between classic psychedelics and other psychoactive drugs in humans. We conducted a thorough literature search using multiple databases, including PubMed, PsycINFO, Web of Science and other sources to supplement our search for relevant studies. A total of 8,487 records published before April 20, 2023, were screened, and studies involving human data describing potential interactions (as well as the lack thereof) between classic psychedelics and other psychoactive drugs were included. In total, we identified 34 reports from 50 studies, encompassing 31 studies on LSD, 11 on psilocybin, 4 on mescaline, 3 on DMT and 1 on ayahuasca. These studies provide insights into the interactions between classic psychedelics and a range of drugs, including antidepressants, antipsychotics, anxiolytics, mood stabilisers, recreational drugs and others. The findings reveal various effects when psychedelics are combined with other drugs, including both attenuated and potentiated effects, as well as instances where no changes were observed. With the exception of a few case reports, no significant adverse drug reactions were discovered in the studies included. In-depth discussions of the results are presented, along with an exploration of potential molecular pathways that underlie the observed effects.

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Alteration of behavioural changes induced by 3,4,5-trimethoxyphenylethylamine (mescaline) by pretreatment with 2,4,5-trimethoxyphenylethylamine

Cited by 11 publications

References 12 publications

Comparison of the behavioral effects of mescaline analogs using the head twitch response in mice

Comparison of the behavioral effects of mescaline analogs using the head twitch response in mice

1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: A Potent Serotonin 5-HT2A/2C Agonist

Drug-drug interactions between classic psychedelics and psychoactive drugs: a systematic review

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