Alteration in topological properties of brain functional network after 2‐year high altitude exposure: A panel study

Xin, Zhenlong; Chen, Xiaoming; Zhang, Qian; Wang, Jiye; Xi, Yi‐Bin; Liu, Jian; Li, Baojuan; Dong, Xiaoru; Lin, Yen-Hui; Zhang, Wenbin; Chen, Jingyuan; Luo, Wenjing

doi:10.1002/brb3.1656

Cited by 10 publications

(6 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The construction of functional brain network was based on the GRETNA toolbox (https://www.nitrc.org/projects/gretna) (45). Previous studies on brain network construction and computation also applied this method (46)(47)(48)(49). Using the Human Brainnetome Atlas, the whole brain was divided into 48 brain regions which are further divided into 246 subregions (no.…”

Section: Network Constructionmentioning

confidence: 99%

Altered Degree Centrality of Brain Networks in Parkinson's Disease With Freezing of Gait: A Resting-State Functional MRI Study

Jin

Teng

et al. 2021

Front. Neurol.

View full text Add to dashboard Cite

Freezing of gait (FOG) in Parkinson's disease (PD) leads to devastating consequences; however, little is known about its functional brain network. We explored the differences in degree centrality (DC) of functional networks among PD with FOG (PD FOG+), PD without FOG (PD FOG–), and healthy control (HC) groups. In all, 24 PD FOG+, 37 PD FOG–, and 22 HCs were recruited and their resting-state functional magnetic imaging images were acquired. The whole brain network was analyzed using graph theory analysis. DC was compared among groups using the two-sample t-test. The DC values of disrupted brain regions were correlated with the FOG Questionnaire (FOGQ) scores. Receiver operating characteristic curve analysis was performed. We found significant differences in DC among groups. Compared with HCs, PD FOG+ patients showed decreased DC in the middle frontal gyrus (MFG), superior temporal gyrus (STG), parahippocampal gyrus (PhG), inferior temporal gyrus (ITG), and middle temporal gyrus (MTG). Compared with HC, PD FOG– presented with decreased DC in the MFG, STG, PhG, and ITG. Compared with PD FOG–, PD FOG+ showed decreased DC in the MFG and ITG. A negative correlation existed between the DC of ITG and FOGQ scores; the DC in ITG could distinguish PD FOG+ from PD FOG– and HC. The calculated AUCs were 81.3, 89.5, and 77.7% for PD FOG+ vs. HC, PD FOG– vs. HC, and PD FOG+ vs. PD FOG–, respectively. In conclusion, decreased DC of ITG in PD FOG+ patients compared to PD FOG– patients and HCs may be a unique feature for PD FOG+ and can likely distinguish PD FOG+ from PD FOG– and HC groups.

show abstract

Section: Network Constructionmentioning

confidence: 99%

Altered Degree Centrality of Brain Networks in Parkinson's Disease With Freezing of Gait: A Resting-State Functional MRI Study

Jin

Teng

et al. 2021

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…Therefore, this type of network facilitates the spread of information over the network ( 75 ). The index of network synchronization reflects the possibility of all the nodes fluctuate in the same wave pattern ( 47 , 76 ). In this study, there were no significant changes in the global measures including network assortative and synchronization, which suggested that NSCLC was not enough to cause topological properties changes of the functional brain network from the global perspective.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, assortativity reflects the tendency of brain regions to be connected to other regions with the same or similar nodal strength. Network synchronization measures how likely it is that all nodes fluctuate in the same wave pattern ( 47 ). More detailed information about these measures could be found in the previous study ( 28 ).…”

Section: Methodsmentioning

confidence: 99%

Topological Abnormalities of Pallido-Thalamo-Cortical Circuit in Functional Brain Network of Patients With Nonchemotherapy With Non-small Cell Lung Cancer

Liu

Yin

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

IntroductionSome previous studies in patients with lung cancer have mainly focused on exploring the cognitive dysfunction and deficits of brain function associated with chemotherapy. However, little is known about functional brain alterations that might occur prior to chemotherapy. Therefore, this study aimed to evaluate brain functional changes in patients with nonchemotherapy before chemotherapy with non-small cell lung cancer (NSCLC).MethodsResting-state functional MRI data of 35 patients with NSCLC and 46 matched healthy controls (HCs) were acquired to construct functional brain networks. Graph theoretical analysis was then applied to investigate the differences of the network and nodal measures between groups. Finally, the receiver operating characteristic (ROC) curve analysis was performed to distinguish between NSCLC and HC.ResultsDecreased nodal strength was found in the left inferior frontal gyrus (opercular part), inferior frontal gyrus (triangular part), inferior occipital gyrus, and right inferior frontal gyrus (triangular part) of patients with NSCLC while increased nodal strength was found in the right pallidum and thalamus. NSCLC also showed decreased nodal betweenness in the right superior occipital gyrus. Different hub regions distribution was found between groups, however, no hub regions showed group differences in the nodal measures. Furthermore, the ROC curve analysis showed good performance in distinguishing NSCLC from HC.ConclusionThese results suggested that topological abnormalities of pallido-thalamo-cortical circuit in functional brain network might be related to NSCLC prior to chemotherapy, which provided new insights concerning the pathophysiological mechanisms of NSCLC and could serve as promising biological markers for the identification of patients with NSCLC.

show abstract

“…Three topological characteristics of the regional network were used to demonstrate the nodal characteristics: degree (D), betweenness centrality (BC) and node efficiency (Enod). D refers to the number of neighbors of a given node, reflecting the importance of the node [50]. BC is defined as the fraction of shortest paths of a network through a given node, which is an indicator of the importance of a node in the network [51].…”

Section: Regional Network Propertiesmentioning

confidence: 99%

Age-related alterations of brain metabolic network based on [18F]FDG-PET of rats

Xue

Huo

et al. 2022

Aging

View full text Add to dashboard Cite

Using animal models to study the underlying mechanisms of aging will create a critical foundation from which to develop new interventions for aging-related brain disorders. Aging-related reorganization of the brain network has been described for the human brain based on functional, metabolic and structural connectivity. However, alterations in the brain metabolic network of aging rats remain unknown. Here, we submitted young and aged rats to [18F]fluorodeoxyglucose with positron emission tomography (18F-FDG PET) and constructed brain metabolic networks. The topological properties were detected, and the network robustness against random failures and targeted attacks was analyzed for age-group comparison. Compared with young rats, aged rats showed reduced betweenness centrality (BC) in the superior colliculus and a decreased degree (D) in the parietal association cortex. With regard to network robustness, the brain metabolic networks of aged rats were more vulnerable to simulated damage, which showed significantly lower local efficiency and clustering coefficients than those of the young rats against targeted attacks and random failures. The findings support the idea that aged rats have similar aging-related changes in the brain metabolic network to the human brain and can therefore be used as a model for aging studies to provide targets for potential therapies that promote healthy aging.

show abstract

Alteration in topological properties of brain functional network after 2‐year high altitude exposure: A panel study

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 10 publications

References 39 publications

Altered Degree Centrality of Brain Networks in Parkinson's Disease With Freezing of Gait: A Resting-State Functional MRI Study

Altered Degree Centrality of Brain Networks in Parkinson's Disease With Freezing of Gait: A Resting-State Functional MRI Study

Topological Abnormalities of Pallido-Thalamo-Cortical Circuit in Functional Brain Network of Patients With Nonchemotherapy With Non-small Cell Lung Cancer

Age-related alterations of brain metabolic network based on [18F]FDG-PET of rats

Contact Info

Product

Resources

About