Alport Syndrome with a Peculiar Pattern of Distribution of the α3–α6 Chains of Type IV Collagen in Renal Basement Membrane

Differential expression of collagen type IV alpha-chains in the tubulointerstitial compartment in experimental chronic serum sickness nephritis

“…26,28 Finally, the unexpected correlations found between the levels of mRNA coding for the collagen 1(IV) and 3(IV) subchains, and between those for the 1(IV) and 4(IV) subchains, support our hypothesis that in pathological conditions a change occurs in the co-expression of these (IV) subchains. [29][30][31] Altered transcription is followed by accumulation of the corresponding proteins. In normal rats, the 1(IV) and 4(IV) chains were found in the TBM, while staining for 3(IV) was only very faint, confirming the results obtained by others.…”

Erythropoietin Response to Folic AcidSubstitution

“…Our dose of FA was twice as high (10 mg daily) as that used by Blumberg et al [2](5 mg) which makes the difference of the overall dose even more striking. Neither Blumberg nor ourselves administered a standardized diet to exclude dietary interferences in intestinal absorption.…”