Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities

Zahra, Maram H.; El‐Aarag, Bishoy; Yosri, Nermeen; El-Ghlban, Samah; Zaki, Kholoud; Marei, Amel H.; El-Wahed, Aida Abd; Saeed, Aamer; Khatib, Alfi; Alajmi, Mohamed F.; Shathili, Abdulrahman M.; Xiao, Jianbo; Khalifa, Shaden A. M.; El-Seedi, Hesham R.

doi:10.3390/molecules24132495

Cited by 26 publications

(24 citation statements)

References 48 publications

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“…T. aphylla possessed anti-oxidant activity [27] owned to its content of different flavonoids [28] and phenolics [29] with potential effects in prevention and treatment of many diseases [30,31,32]. As part of our ongoing research to identify a new effective and functional natural component [33,34,35,36] with high availability and low cost, the present study aims to investigate the anti-oxidant, anti-apoptotic, and anti-proliferative activities of 3,5-dihydroxy-4′,7-dimethoxyflavone (Figure 1) isolated from T. aphylla. The long-term goal is to develop a potent pharmaceutical agent that inhibits the production and activation of free radicals and acts against CCl 4 -induced liver injury in mice.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Flavone from Tamarix aphylla against CCl4-Induced Liver Injury in Mice Mediated by Suppression of Oxidative Stress, Apoptosis and Angiogenesis

El‐Aarag

Khairy

Khalifa

et al. 2019

IJMS

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The current study aimed to investigate, for the first time, the beneficial effects of 3,5-dihydroxy-4′,7-dimethoxyflavone isolated from Tamarix aphylla L. against liver injury in mice. Liver injury was induced by intraperitoneal (i.p.) injection of carbon tetrachloride (CCl4) at a dose of 0.4 mL/kg mixed in olive oil at ratio (1:4) twice a week for 6 consecutive weeks. The administration of CCl4 caused significant histopathological changes in liver tissues while the pre-treatment with the flavone at dose of 10 and 25 mg/kg ameliorated the observed liver damages. Also, it markedly reduced hepatic malondialdehyde (MDA) level as well as increased the activities of liver superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (Gpx) compared with their recorded levels in CCl4 model group. Moreover, the immunohistochemical analysis demonstrated the enhancement in the protein level of B-cell lymphoma-2 (Bcl-2) while the protein levels of cysteine-aspartic acid protease-3 (caspase-3), Bcl-2-associated x protein (Bax), transforming growth factor-β1 (TGF-β1) and CD31 were suppressed following the flavone treatement. These results suggest that the flavone can inhibit liver injury induced in mice owning to its impact on the oxidation, apoptotic and angiogenesis mechanisms. Further pharmacological investigations are essential to determine the effectiveness of the flavone in human.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of Flavone from Tamarix aphylla against CCl4-Induced Liver Injury in Mice Mediated by Suppression of Oxidative Stress, Apoptosis and Angiogenesis

El‐Aarag

Khairy

Khalifa

et al. 2019

IJMS

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“…The solid tumor was induced by subcutaneously (SC) injecting 1 × 10 −6 EAC cells into the right thigh of the lower limb of mice [84,85]. Seven days after tumor inoculation, the tumor volume became palpable.…”

Section: Methodsmentioning

confidence: 99%

Synthesis, Characterization, and In Vivo Anti-Cancer Activity of New Metal Complexes Derived from Isatin-N(4)antipyrinethiosemicarbazone Ligand Against Ehrlich Ascites Carcinoma Cells

et al. 2019

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The current study aimed to synthesize new metal coordination complexes with potential biomedical applications. Metal complexes were prepared via the reaction of isatin-N(4)anti- pyrinethiosemicarbazone ligand 1 with Cu(II), Ni(II), Co(II), Zn(II), and Fe(III) ions. The obtained metal complexes 2−12 were characterized using elemental, spectral (1H-NMR, EPR, Mass, IR, UV-Vis) and thermal (TGA) techniques, as well as magnetic moment and molar conductance measurements. In addition, their geometries were studied using EPR and UV−Vis spectroscopy. To evaluate the in vivo anti-cancer activities of these complexes, the ligand 1 and its metal complexes 2, 7 and 9 were tested against solid tumors. The solid tumors were induced by subcutaneous (SC) injection of Ehrlich ascites carcinoma (EAC) cells in mice. The impact of the selected complexes on the reduction of tumor volume was determined. Also, the expression levels of vascular endothelial growth factor (VEGF) and cysteine aspartyl-specific protease-7 (caspase-7) in tumor and liver tissues of mice bearing EAC tumor were determined. Moreover, their effects on alanine transaminase (ALT), aspartate transaminase (AST), albumin, and glucose levels were measured. The results revealed that the tested compounds, especially complex 9, reduced tumor volume, inhibited the expression of VEGF, and induced the expression of caspase-7. Additionally, they restored the levels of ALT, AST, albumin, and glucose close to their normal levels. Taken together, our newly synthesized metal complexes are promising anti-cancer agents against solid tumors induced by EAC cells as supported by the inhibition of VEGF and induction of caspase-7.

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“…Chien và cộng sự đã công bố kết quả nghiên cứu về tác động chống viêm của các hợp chất phân lập từ Z. zerumbet được thử nghiệm trên chuột và trên tế bào nuôi cấy in vitro [6]. Bên cạnh đó, hoạt tính kháng tế bào ung thư của Gừng gió đã được đề cập ở một số dạng ung thư khác nhau [7]- [9].…”

Section: Giới Thiệuunclassified

Ảnh Hưởng Của Cao Chiết Ethanol Từ Cây Gừng Gió (Zinginber Zerumbet) Lên Sự Tăng Sinh, Chu Kỳ Tế Bào, Apoptosis Và Khả Năng Di Trú Của Tế Bào Ung Thư Dạ Dày Ags

Hung¹,

Hương²,

Linh³

et al. 2021

TNUJST

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Ung thư dạ dày là dạng ung thư ác tính và phổ biến trên thế giới. Mặc dù đã có nhiều tiến bộ trong điều trị hiện nay đối với ung thư dạ dày, song tỷ lệ chết vì loại ung thư này còn cao, đòi hỏi tiếp tục phải nghiên cứu tìm kiếm các loại thuốc và chế phẩm hỗ trợ điều trị mới. Trong nghiên cứu này, chúng tôi đánh giá tác động của dịch chiết ethanol từ lá của cây Gừng gió lên sự tăng sinh, chu kỳ tế bào, apoptosis bằng các phân tích MTT, Flow cytometry và di trú tế bào. Kết quả cho thấy rằng, dịch chiết ethanol từ lá cây Gừng gió làm chậm sự tăng lên về số lượng của tế bào AGS với giá trị IC50 trong 48h xử lý là 2,09 mg/mL. Ở nồng độ 0,2 mg/mL, dịch chiết đã làm dừng chu kỳ tế bào ở pha G0/G1 với tỷ lệ tích lũy tế bào ở pha này là 74,4% so với 66,9% ở mẫu đối chứng. Tỷ lệ apoptosis tăng lên 14,0% (0,2 mg/mL) và 61,2% so với 4,4% ở mẫu đối chứng. Xa hơn nữa, dịch chiết từ lá cây Gừng gió đã làm giảm khả năng di trú của tế bào AGS. Dữ liệu thu được từ nghiên cứu này cho thấy, Gừng gió là cây thuốc tiềm năng để chống lại ung thư dạ dày.

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Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities

Cited by 26 publications

References 48 publications

Protective Effects of Flavone from Tamarix aphylla against CCl4-Induced Liver Injury in Mice Mediated by Suppression of Oxidative Stress, Apoptosis and Angiogenesis

Protective Effects of Flavone from Tamarix aphylla against CCl4-Induced Liver Injury in Mice Mediated by Suppression of Oxidative Stress, Apoptosis and Angiogenesis

Synthesis, Characterization, and In Vivo Anti-Cancer Activity of New Metal Complexes Derived from Isatin-N(4)antipyrinethiosemicarbazone Ligand Against Ehrlich Ascites Carcinoma Cells

Ảnh Hưởng Của Cao Chiết Ethanol Từ Cây Gừng Gió (Zinginber Zerumbet) Lên Sự Tăng Sinh, Chu Kỳ Tế Bào, Apoptosis Và Khả Năng Di Trú Của Tế Bào Ung Thư Dạ Dày Ags

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