2011
DOI: 10.1111/j.1369-1600.2010.00293.x View full text |Buy / Rent full text
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Abstract: Research suggests that alpha-synuclein (SNCA) and NACP-Rep1, a polymorphic complex microsatellite repeat ~10 kb upstream of the SNCA gene translational start, may be involved in substance-use behaviors and craving. This study was the first to examine the effects of diacetylmorphine (DAM) on peripheral SNCA protein expression along with craving in opiate-dependent patients and to compare their NACP-Rep1 allele lengths with those of healthy controls. Using an experimental design, opiate-dependent patients on inj… Show more

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“…Such observations are highly suggestive of α-synuclein participation in opioid-elicited effects on the dopaminergic reward pathway [132]. Indeed, besides leading to cellular stress and toxicity, increases in α-synuclein levels have been associated with predisposition to addiction to different drugs of abuse, such as cocaine and alcohol [132][133][134]. Although α-synuclein mRNA levels decreased upon exposure to 50 mg/kg tramadol and tapentadol (Figure 3c), such alterations were reflected at the protein level for 50 mg/kg tramadol, 10 and 25 mg/kg tapentadol only (Figure 4).…”
Section: Repeated Exposure To Tramadol and Tapentadol Alters The Exprmentioning
“…Aggregates of misfolded, toxic forms are reported in synucleinopathies, having been associated with alterations in structural cell components, multiple cellular pathways, protein clearance mechanisms and mitochondrial function [131]. This pre-synaptic protein has also been shown to negatively regulate dopaminergic neurotransmission, since it decreases the expression and inhibits the activity of enzymes involved in dopamine synthesis, affects the activity of dopamine transporters and the capacity of refilling and storage of pre-synaptic dopamine-containing vesicles [132,133]. Such observations are highly suggestive of α-synuclein participation in opioid-elicited effects on the dopaminergic reward pathway [132].…”
Section: Repeated Exposure To Tramadol and Tapentadol Alters The Exprmentioning
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