Alpha Rhythm in Classical Migraine (Migraine with Aura): Abnormalities in the Headache-Free Interval

Nyrke, T.; Kangasniemi, P; Lang, Heikki

doi:10.1046/j.1468-2982.1990.1004177.x

Cited by 39 publications

(37 citation statements)

References 14 publications

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“…The mild abnormality of the posterior (parieto-occipital) alpha rhythm reported by prior authors (Jonkman and Lelieveld 1981;Fachetti et al 1990;Nyrke et al 1990;Neufeld et al 1991;Drake et al 1988;Vonderheid-Guth et al 2000) was essentially confirmed in this study. Spectral analysis and LORETA confirmed the selective involvement of the alpha band and localized the generators of increased alpha activity in the right posterior region of the cortex.…”

Section: Increased Posterior Alpha Activitysupporting

confidence: 89%

“…Spectral analysis and LORETA confirmed the selective involvement of the alpha band and localized the generators of increased alpha activity in the right posterior region of the cortex. We confirmed that the occipital alpha abnormality is the most characteristic QEEG abnormality in migraine (Jonkman and Lelieveld 1981;Fachetti et al 1990;Nyrke et al 1990;Neufeld et al 1991;Drake et al 1988). One remaining question is the unilateral or bilateral distribution of the abnormality, an issue that has not been answered by the quoted authors.…”

Section: Increased Posterior Alpha Activitysupporting

confidence: 73%

“…The color P-scale refers to the statistically significant differences. Red color indicates greater activity in the migraine than in the control group, blue color indicates the reverse Brain Topogr (2008) 21:36-42 39 QEEG alterations (Jonkman and Lelieveld 1981;Fachetti et al 1990;Nyrke et al 1990;Neufeld et al 1991;Drake et al 1988;Vonderheid-Guth et al 2000). The consistency of the findings suggested that they reflect the state of the cortex that is common to most or all migraine patients in the interval.…”

Section: Application Of Qeeg and Loreta To Migraine Research And The mentioning

confidence: 99%

“…The essence of the QEEG findings was the presence of mild abnormalities of the posterior alpha rhythm (Jonkman and Lelieveld 1981;Fachetti et al 1990;Nyrke et al 1990;Neufeld et al 1991;Drake et al 1988). Besides the posterior abnormality, a few investigators found abnormal EEG spectral power in the frontal and temporal cortex (Vonderheid-Guth et al 2000).…”

Section: Introductionmentioning

confidence: 99%

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Three-dimensional Localization of Abnormal EEG Activity in Migraine

et al. 2008

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Investigating the brain of migraine patients in the pain-free interval may shed light on the basic cerebral abnormality of migraine, in other words, the liability of the brain to generate migraine attacks from time to time. Twenty unmedicated "migraine without aura" patients and a matched group of healthy controls were investigated in this explorative study. 19-channel EEG was recorded against the linked ears reference and was on-line digitized. 60 x 2-s epochs of eyes-closed, waking-relaxed activity were subjected to spectral analysis and a source localization method, low resolution electromagnetic tomography (LORETA). Absolute power was computed for 19 electrodes and four frequency bands (delta: 1.5-3.5 Hz, theta: 4.0-7.5 Hz, alpha: 8.0-12.5 Hz, beta: 13.0-25.0 Hz). LORETA "activity" (=current source density, ampers/meters squared) was computed for 2394 voxels and the above specified frequency bands. Group comparison was carried out for the specified quantitative EEG variables. Activity in the two groups was compared on a voxel-by-voxel basis for each frequency band. Statistically significant (uncorrected P < 0.01) group differences were projected to cortical anatomy. Spectral findings: there was a tendency for more alpha power in the migraine that in the control group in all but two (F4, C3) derivations. However, statistically significant (P < 0.01, Bonferroni-corrected) spectral difference was only found in the right occipital region. The main LORETA-finding was that voxels with P < 0.01 differences were crowded in anatomically contiguous cortical areas. Increased alpha activity was found in a cortical area including part of the precuneus, and the posterior part of the middle temporal gyrus in the right hemisphere. Decreased alpha activity was found bilaterally in medial parts of the frontal cortex including the anterior cingulate and the superior and medial frontal gyri. Neither spectral analysis, nor LORETA revealed statistically significant differences in the delta, theta, and beta bands. LORETA revealed the anatomical distribution of the cortical sources (generators) of the EEG abnormalities in migraine. The findings characterize the state of the cerebral cortex in the pain-free interval and might be suitable for planning forthcoming investigations.

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Section: Increased Posterior Alpha Activitysupporting

confidence: 89%

Section: Increased Posterior Alpha Activitysupporting

confidence: 73%

Section: Application Of Qeeg and Loreta To Migraine Research And The mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Three-dimensional Localization of Abnormal EEG Activity in Migraine

et al. 2008

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“…In this regard, Nyrke et al [11] carried out several EEG recordings at different time intervals relative to the crises and found an increase in bioelectrical abnormalities mostly concerning the alpha band in the period immediately preceding the attacks compared to 10 days before.…”

Section: Eeg Mapping During Migraine Attacksmentioning

confidence: 99%

Electroencephalographic brain mapping and migraine

2004

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IntroductionResearch from electroencephalographic examinations in patients with primary headaches has yielded controversial results. Some studies confirmed the presence of bioelectrical abnormalities in the electroencephalogram (EEG) in primary headache patients, particularly in migraine patients with and without aura. In contrast, other studies did not show abnormalities or any significant differences between headache patients and healthy control subjects. Andrea Alberti Giovanni Mazzotta Francesca Galletti Paola SarchielliAbstract Several studies have investigated brain bioelectrical activity with the aid of electroencephalographic brain mapping in migraine patients examined in the interictal period or during a spontaneous attack. The principal finding obtained between attacks was an increase in the power of the rapid activities, particularly in the range of the beta bands and especially in the temporal regions, in migraine patients both with and without aura. Another frequent occurrence between attacks is an increase in the absolute and relative powers of the slow theta and delta bands, which can be focal or diffuse. In our experience, the increase in the relative power of the theta band was prevalent bilaterally in the temporal-parietal regions in migraineurs with and without aura. Other authors detected interhemispheric asymmetries relative to alpha bands, more consistent in patients with migraine with aura. During attacks the most relevant result is the decrease and asymmetry of dominant alpha activity, particularly on the side of the pain during attacks in patients with migraine without aura. In addition to changes in the alpha activities, an increase in the power of the slow delta and/or theta bands was found during attacks of migraine with aura. Although difficult to summarize in an integrated view, results of EEG brain mapping support the occurrence of bioelectrical abnormalities, which are present even between attacks and contribute towards defining the attack threshold, and which are accentuated near and during migraine crises as a consequence of neuronal events that underlie the pathogenic mechanisms of attacks.

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