Alpha-lipoic acid in the treatment of diabetic polyneuropathy

Chukanova, E I; Chukanova, A. S.

doi:10.17116/jnevro201811811103-109

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…It also possesses therapeutic effects in the treatment of diabetes, peripheral neuropathy, male infertility disease, etc. (11)(12)(13). The present study further explored whether LA could improve the spermatogenesis disorder induced by PFOA in rats.…”

Section: Introductionmentioning

confidence: 89%

Efficacy and mechanism of lipoic acid in the treatment of reproductive injury caused by perfluorooctanoic acid

et al. 2023

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Environmental pollutants, including perfluorooctanoic acid (PFOA), cause severe reproductive damage to humans and animals. Lipoic acid (LA) is a strong antioxidant that alleviates the oxidative damage caused by heavy metals, environmental toxicants, chemical poisons, etc. Therefore, the present study investigated the curative effect and mechanism of LA in treating spermatogenesis dysfunction caused by PFOA. A rat reproductive injury model was established by gavage of PFOA for consecutive 30 days and then rats were treated with different doses of LA for 42 days. The effects were assessed by ELISA, western blotting, H&E staining and immunofluorescence staining. The results demonstrated that LA had ameliorating effects on PFOA-induced reproductive injury in rats, it increased the sperm counts, and the levels of serum succinate dehydrogenase, lactate dehydrogenase, glutathione peroxidase and superoxide dismutase returned to normal levels following LA treatment. In addition, LA promoted the expression of estradiol, reduced the expression of serum sex hormones, such as follicle-stimulating hormone, androgen receptor (AR) and malondialdehyde in the testes, and restored the structure of seminiferous tubules. Its therapeutic mechanisms include regulating the testicular oxidative stress pathway and hypothalamic-pituitary-testis axis.

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Section: Introductionmentioning

confidence: 89%

Efficacy and mechanism of lipoic acid in the treatment of reproductive injury caused by perfluorooctanoic acid

et al. 2023

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“…Обладая положительным липотропным действием, обеспечивает передачу ацетата и жирных кислот из цитозоля клетки в среду матрикса митохондрий, в которой происходит их окисление. Альфа-липоевая кислота и её восстановленная форма обладают антиоксидантными свойствами (повышают уровень глутатиона, восстанавливают уровни других антиоксидантов -витаминов С и Е, способствуют нейтрализации свободных радикалов и ряда ксенобиотиков) [26][27][28][29].…”

Section: результатыunclassified

The role of information service in rational pharmacotherapy with thioctic acid in patients in Preferential Medicinal Providing

Елисеева

Манеева

Грибова

et al. 2021

GCP

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Rational pharmacotherapy in the Program of Preferential Medicinal Providing can be implemented subject to high-quality information support from healthcare professionals. Thioctic (Alpha-lipoic) Acid preparations are widely used in the preferential segment, their appointment is not always advisable due to the frequent use «off-label», which leads to ineffective treatment and unreasonable economic costs. Aim. Conduct an information search and filling the electronic service «Database of Clinical Trials of Medicines» for medicinal products containing Thioctic (Alpha-lipoic) Acid and provide author’s recommendations for rational pharmacotherapy. Materials and methods. The search and analysis of the results of clinical trials, systematic reviews and meta-analysis in international and Russian Databases — PubMed, EMBASE, Cochrane Collaboration, e-Library, «Cyberlininka» for medicines of metabolic action — Thioctic (Alpha-lipoic) Acid with their subsequent introduction into the Information Service «Database of Clinical Trials of Medicines». Results. Thioctic (Alpha-lipoic) Acid has a positive effect in the form of improvement of the clinical condition of patients and indicators of neurological scales in diabetic and alcoholic polyneuropathy without affecting the «hard» endpoints (decrease in the number of fatal complications and mortality). Conclusion. Service «Database of Clinical Trials of Medicines» for use by health care professionals and the author’s recommendations for the use of Thioctic (Alpha-lipoic) Acid can be used for the rational prescription of this medicines in Preferential Medicinal Providing.

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“…5 Currently, lipoic acid (LA) is the strongest natural antioxidant known, with both fat-and water-soluble properties. [6][7][8] It can remove active oxygen free radicals in the body and inhibit many redox-sensitive signaling pathways. In addition, LA is also a key auxiliary group of various enzymes such as pyruvate dehydrogenase and α-ketoglutarate dehydrogenase in the mitochondria, which can promote and improve oxidative phosphorylation and stabilize the mitochondrial respiratory chain, improve mitochondrial function, and reduce the occurrence of cellular apoptosis or death.…”

Section: Introductionmentioning

confidence: 99%

<p>Lipoic Acid Decreases the Expression of Poly ADP-Ribose Polymerase and Inhibits Apoptosis in Diabetic Rats</p>

Chen¹,

Li²

2020

DMSO

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Purpose: To study the effects of lipoic acid on poly ADP-ribose polymerase (PARP) expression and apoptosis in diabetic rats. Materials and Methods: Sprague-Dawley rats (n=30) with high-fat diet-and streptozotocin-induced diabetes were randomly divided into two groups: diabetic model (DM) group and lipoic acid (LA) treatment group; another 10 rats were selected as normal controls (NC). The serum levels of 8-hydroxy-2ʹ-deoxyguanosine, nitrotyrosine, and 8-isoprostane; sciatic nerve cell apoptosis index; and PARP expression were detected in the rats, and morphological changes in the sciatic nerve were recorded. Results: The blood glucose level in the DM and LA groups was significantly higher than that of the NC group (P<0.01). Compared to the NC group, the DM group showed demyelinating changes to sciatic nerve fibers. PARP expression; serum levels of 8-hydroxy-2-deoxyguanosine, nitrotyrosine, and 8-isoprostane; and the apoptosis index of sciatic nerve cells were significantly higher than those of the NC group (P<0. 01). Following LA treatment, the above indices showed significant improvement (P<0.01). Conclusion: Lipoic acid may improve the symptoms of diabetic neuropathy by reducing PARP activity and inhibiting apoptosis.

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Alpha-lipoic acid in the treatment of diabetic polyneuropathy

Cited by 6 publications

References 21 publications

Efficacy and mechanism of lipoic acid in the treatment of reproductive injury caused by perfluorooctanoic acid

Efficacy and mechanism of lipoic acid in the treatment of reproductive injury caused by perfluorooctanoic acid

The role of information service in rational pharmacotherapy with thioctic acid in patients in Preferential Medicinal Providing

<p>Lipoic Acid Decreases the Expression of Poly ADP-Ribose Polymerase and Inhibits Apoptosis in Diabetic Rats</p>

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