Alpha-Haloethers: A New Type of Alkylating Carcinogen

Duuren, Benjamin L. Van; Goldschmidt, B. M.; Katz, Chen; Langseth, L; Mercado, Guadalupe; Sivak, Andrew

doi:10.1080/00039896.1968.10665092

Cited by 64 publications

(12 citation statements)

References 3 publications

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“…The area values indicate the good linearity of the method and establish a detection limit of -1 ppt. This compares with a published detection limit for the medium resolution SIM GC/MS technique of 10 ppt' (moreover the ICI experience is that this latter 51 I 57 1 figure is rarely achievable for real samples due to interferences).…”

Section: Resülts and Discussion '3mentioning

confidence: 56%

The determination of atmospheric bis (chloromethyl) ether by gas chromatography/tandem mass spectrometry

Blease

Scrivens

Morden³

1989

Biol. Mass Spectrom.

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The technique of gas chromatography/tandem mass spectrometry is applied to the analysis of bis(chloromethy1) ether in laboratory and production environments. A selected reaction monitoring method is sbown to yield superior sensitivity and selectivity to previous methods. A detection limit of -1 ppt is established even for chemically complex atmospheres which have proved intractable by previous techniques.

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Section: Resülts and Discussion '3mentioning

confidence: 56%

The determination of atmospheric bis (chloromethyl) ether by gas chromatography/tandem mass spectrometry

Blease

Scrivens

Morden³

1989

Biol. Mass Spectrom.

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“…Both chloromethyl methyl ether (CMME) and bischloromethyl ether (BCME), which might occur in commercial CMME at about 1-7%, are highly reactive alpha-haloethers and potent cancer initiators in animals (Van Duuren et al, 1968;Laskin et al, 1971;Leong et al, 1971), apparently even at such low concentrations as 0.1 ppm BCME in long-term exposure experiments in rats. Lung cancer has been reported in several industrial populations exposed to both CMME (Figueroa et al, 1973;Fishbein, 1972) and BCME (Sakabe, 1973;Thiess et al, 1973).…”

Section: Other Chlorinated Hydrocarbons and Human Cancermentioning

confidence: 99%

Chlorinated hydrocarbons and cancer: Epidemiologic aspects

Axelson

1980

Journal of Toxicology and Environmental Health

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“…Although the alkylating agent, chloromethyl methyl ether (CMME), has been produced and used in this country since shortly after World War II as a crosslinking agent for ion-exchange resins and as an intermediate in the production of organic chemicals, it was not until 20 years later that its carcinogenic potential was demonstrated in animals. Beginning in 1968, Van Duuren et al (1,2) reported that CMME was carcinogenic for the mouse skin, and that bischloromethyl ether (BCME), which is an impurity (2-8%o) in commercial CMME, was an even more potent carcinogen.…”

Section: Mortality Patterns Among Workers Exposed Tomentioning

confidence: 99%

Mortality patterns among workers exposed to chloromethyl ethers--a preliminary report.

Albert¹,

Pasternack²,

Shore³

et al. 1975

Environ Health Perspect

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Chloromethyl methyl ether (CMME) has been used extensively as a crosslinking agent for ion-exchange resins. Commercial grades of CMME are contaminated to the extent of 2-8% with bischloromethyl ether, an alkylating agent which has been shown to be a very potent lung carcinogen in animals. Reports by other investigators in this and other countries have implicated CMME as a lung carcinogen in chemical workers. The purpose of the study reported here was to examine the lung cancer mortality experience with respect to intensity and duration of exposure in six of the seven chemical companies that account for virtually all of the CMME use in the United States. The study included about 1800 workers who were exposed in the period 1948 to 1972 and about 8000 workers not exposed to CMME from the same plants who served as controls. Exposed workers were characterized according to job description and duration of exposure. In several plants the intensity of exposure was numerically graded for each job category with adjustment for temporal changes in the plant processes. Social Security records were used to identify deaths among workers who had left the companies and death certificates have been obtained for virtually all known deaths. The age-adjusted death rate for respiratory cancer in the CMME exposed group as a whole was 2.5 times that in the control group, whereas death rates due to other causes were comparable. There was also a gradation of lung cancer risk according to intensity and duration of exposure and the time elapsed since the onset of exposure.

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Alpha-Haloethers: A New Type of Alkylating Carcinogen

Cited by 64 publications

References 3 publications

The determination of atmospheric bis (chloromethyl) ether by gas chromatography/tandem mass spectrometry

The determination of atmospheric bis (chloromethyl) ether by gas chromatography/tandem mass spectrometry

Chlorinated hydrocarbons and cancer: Epidemiologic aspects

Mortality patterns among workers exposed to chloromethyl ethers--a preliminary report.

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