Alopecia Areata Occurring Simultaneously in Identical Twins

Tratamento da alopecia areata com corticóide tópico: estudo prospectivo randomizado duplo cego em crianças

“…10 In this research two monozygotic twins being studied concomitantly had almost identical lesions in terms of location and size. This phenomenon, although already described, [11][12][13] is extremely rare. In spite of the different treatments (one used BD, and other a placebo), they both coursed with total repilation and within the same period.…”

“…Os dados da literatura não apontam predominância de sexo. 10 Neste estudo duas gêmeas monozigóticas apresentaram o quadro concomitantemente; a localização e o tamanho das lesões eram quase idênticos; o fato, embora já descrito, 11,12,13 é extremamente raro. Apesar do tratamento diferente (uma utilizou DB, e outra, placebo), evoluíram com repilação total no mesmo período de tempo.…”

Alopecia Areata

“…Previous studies have shown that at least some forms of AA are inherited [86][87][88], as AA occurs in identical twins [89][90][91][92][93][94], siblings [95] and in multiple generations of family members with AA [87,96,97]. A strong association between AA and trisomy 21 (Down syndrome) has been observed [98,99].…”

Major Locus on Mouse Chromosome 17 and Minor Locus on Chromosome 9 are Linked with Alopecia Areata in C3H/HeJ Mice

“…AA is most likely a disorder of multifactorial etiologies comprising immunologic, environmental, and genetic components. A strong genetic in£uence is supported by increased concordance in identical twins (Hendren, 1949;Weidman et al, 1956;Barsky and Gigli, 1961;Bonjean et al, 1968;Cole and Herzlinger, 1984;Werth et al, 1992) or siblings (Insler and Helm, 1989) as well as identi¢cation of families with several generations of members with AA (Hordinsky et al, 1984;Van der Steen et al, 1992;Dawn and Kumar, 1996). Human AA gene association studies focus on the major histocompatibility locus, HLA, as the most likely region for genes that regulate susceptibility or resistance to AA, as AA is considered to be an autoimmune disease (Duvic et al, 1991;Morling et al, 1991;Welsh et al, 1994;Colombe et al, 1999;deAndrade et al, 1999;Kavak et al, 2000).…”