Allografts in Anterior Cruciate Ligament Reconstruction

Iosifidis, Michael; Tsarouhas, Alexandros

doi:10.1007/978-3-642-15630-4_58

Cited by 5 publications

(3 citation statements)

References 71 publications

(84 reference statements)

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“…However, choosing the type of graft may be challenging because allografts for ACLR have unique problems. The main drawbacks include increased failure rates in young and active athletes, higher costs, delayed graft integration, and potential disease transmission (bacterial, viral, and prion) 27) .…”

Section: Graft Types Of Aclrmentioning

confidence: 99%

The Risk Factors and Preventive Strategies of Poor Knee Functions and Osteoarthritis after Anterior Cruciate Ligament Reconstruction: A Narrative Review

ADHITYA,

KURNIAWATI,

SAWA

et al. 2023

Phys Ther Res

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Anterior cruciate ligament reconstruction (ACLR) is the standard surgical treatment for ACL injury, which typically uses a graft to replace the torn ligament in the knee that uses small incisions with minimally invasive surgery. The optimal knee functions following ACLR depend on rehabilitation processes before and after the surgery. Knee function is the ability of the knee to perform various types of functional movements like walking, squatting, running, jumping, and pivoting where patients expect to achieve maximum knee function or at least more than 80% of its initial condition before the injury to avoid being categorized as poor knee function after ACLR. Patients use patient-reported outcome measures to collect data on their health status and quality of life after ACLR. Post-traumatic osteoarthritis (PTOA) is a type of OA that manifests in local cartilage injury caused by chondrocyte death, and matrix dispersion occurs following a joint injury like ACL injury. Gender, time from injury to surgery, and graft type were considered as risk factors for poor knee function after ACLR, while overweight, meniscus tear, and cartilage defect as risk factors for PTOA. However, age is an internal risk factor for both poor knee function and PTOA following ACLR. This review suggests several strategies to prevent both conditions, including a pre-operative program, comprehensive rehabilitation, body weight control, and return to sport (RTS) consideration based on physical capacity, proper time, and psychological readiness.

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Section: Graft Types Of Aclrmentioning

confidence: 99%

The Risk Factors and Preventive Strategies of Poor Knee Functions and Osteoarthritis after Anterior Cruciate Ligament Reconstruction: A Narrative Review

ADHITYA,

KURNIAWATI,

SAWA

et al. 2023

Phys Ther Res

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“…Autografts include BPTB and hamstring tendons. Allografts are usually taken from the posterior tendon, Achilles tendon, Tibialis anterior tendon, BPTB and Peroneus longus tendons (Iosifidis and Alexandros, 2012). Puji et al (2017) demonstrated that BPTB autografts have better outcomes following surgery, as assessed by the presence of knee and kneeling pain.…”

Section: Dmentioning

confidence: 99%

Tissue engineering approaches for the repair and regeneration of the anterior cruciate ligament: towards 3D bioprinted ACL-on-chip

Bakirci¹,

Guénat²,

Ahmad³

et al. 2022

eCM

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The anterior cruciate ligament (ACL) is the most frequently injured ligament in the knee. The current method to treat the injured ligament is reconstruction using autografts and allografts. Reconstruction requires the regeneration of ligament, bone and their interface to ensure proper recovery. Recently, researchers have focused on using tissue-engineered scaffolds made of synthetic materials and biomaterials —such as collagen, decellularised tissues, silk and synthetic polymers produced following different manufacturing methods — for ACL reconstruction,. Different materials can be easily processed using various fabrication methods for mimicking the mechanical properties of the ACL. The advances in technologies play an important role in the production of constructions that can mimic native ACL.. The present review addresses integrative scaffold design, different challenges in the potential materials and manufacturing methods as well as future strategies for ACL repair. Furthermore, the review provides a road map to 3D printing combined with organ-on-chip technology to demonstrate the potential for cost-effective and user-friendly fabrication methods for ACL engineering. Finally, it underlines the potential of 3D bioprinting and organ-on-chip technologies for micro-engineering of ligaments and their associated environment.

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“…14 Because of their natural structure and similarities to the human tissue structure, these materials are assumed to be most suitable for clinical use. Naturally derived materials are mostly classified according to their origin as allogeneic (human), 15 xenogeneic (animal), 16,17 or phycogeneic (plant). 18 In the group of BSMs, natural bone is obtained from the same or a different species and purified/processed to be suitable for human clinical applications.…”

Section: Introductionmentioning

confidence: 99%

The Biomaterial-Induced Cellular Reaction Allows a Novel Classification System Regardless of the Biomaterials Origin

Al‐Maawi

Rutkowski

Sader

et al. 2020

Journal of Oral Implantology

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Several different biomaterials are being introduced for clinical applications. However, no current material-specific systematic studies define parameters for evaluating these materials. The aim of this retrospective animal study is to classify biomaterials according to the in vivo induced cellular reaction and outline the clinical consequence of the biomaterial-specific cellular reaction for the regeneration process. A retrospective histologic analysis was performed for 13 polymeric biomaterials and 19 bone substitute materials (BSMs) (of various compositions and origins) that were previously implanted in a standardized subcutaneous model. Semiquantitative analyses were performed at days 3, 15, and 30 after implantation according to a standardized score for the induction of multinucleated giant cells (MNGCs) and vascularization rate. The induced cellular reaction in response to different polymeric materials allowed their classification according to the MNGC score in the following groups: class I induced no MNGCs at any time point, class II induced and maintained a constant number of MNGCs over 30 days, and class III induced MNGCs and provided an increasing number over 30 days. All BSMs induced MNGCs to varying extents. Therefore, the resultant BSM classifications are as follows: class I induced MNGCs with a decreasing number, class II induced and maintained constant MNGCs over 30 days, and class III induced MNGCs with increasing number over 30 days. These observations were mostly related to the biomaterial physicochemical properties and were independent of the biomaterial origin. Consequently, the induction of MNGCs and their increase over 30 days resulted in disintegration of the biomaterial. By contrast, the absence of MNGCs resulted in an integration of the biomaterial within the host tissue. This novel classification provides clinicians a tool to assess the capacity and suitability of biomaterials in the intended clinical indication for bone and soft tissue implantations.

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Allografts in Anterior Cruciate Ligament Reconstruction

Cited by 5 publications

References 71 publications

The Risk Factors and Preventive Strategies of Poor Knee Functions and Osteoarthritis after Anterior Cruciate Ligament Reconstruction: A Narrative Review

The Risk Factors and Preventive Strategies of Poor Knee Functions and Osteoarthritis after Anterior Cruciate Ligament Reconstruction: A Narrative Review

Tissue engineering approaches for the repair and regeneration of the anterior cruciate ligament: towards 3D bioprinted ACL-on-chip

The Biomaterial-Induced Cellular Reaction Allows a Novel Classification System Regardless of the Biomaterials Origin

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