Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water

Antioxidant effects of continuous intake of electrolyzed hydrogen water in healthy adults

“…The findings of the present study are that the continuous intake of EHW is effective to reduce oxidative stress even in healthy individuals, not only the patients with oxidative stress-related diseases. We recently reported that elevated oxidative stress is attenuated by EHW administration of rats with chronic stress or fatigue [ 3 ]. In our human study, an increase in concentration of d-ROMs in healthy adults with accumulation of stress and fatigue is observed [ 11 ].…”

“…Electrolytic hydrogen water (EHW) contains abundant molecular hydrogen and very small amounts of platinum nanoparticles with alkaline properties and has a scavenging activity of antioxidants toward ROS [ 2 ]. In our recent study, EHW intake of rats with chronic stress induces decrease in the serum concentration of reactive oxygen metabolites-derived compounds (d-ROMs) and oxidative stress index (OSI) as markers of oxidative stress [ 3 ]. The OSI is calculated using the following formula: OSI = C [d-ROMs/biological antioxidant potential (BAP)] where C denotes a coefficient for standardization to set the mean OSI in healthy individuals at 1.0 (C = 8.85) [ 4 ].…”

Electrolyzed Hydrogen Water Protects against Ethanol-Induced Cytotoxicity by Regulating Aldehyde Metabolism-Associated Enzymes in the Hepatic Cell Line HepG2

“…EHW was obtained from a previously reported apparatus, TRIM ION GRACE (Nihon Trim Co., Osaka, Japan) [ 6 ]. In brief, tap water is first passed through an activated charcoal filter for removal of bacteria and other microscopic impurities, then subject to electrolysis for enrichment in hydrogen.…”

“…These EHW and hydrogen water properties have been verified by animal experiments to contribute to the alleviation of pathological conditions such as diabetes, arteriosclerosis, and neurodegenerative diseases, which are closely related to oxidative stress [ 3 , 4 , 5 ]. A recent study also showed that in a rat model of sustained stress-loading, pre-treatment with EHW significantly suppressed the elevation of peroxides, prevented the decline in antioxidant capacity in the blood, and significantly suppressed the elevation of inflammatory marker, IL-1β, and stress response hormone, ACTH [ 6 ]. In addition, a non-randomized, non-blinded, prospective observational study reported that hemodialysis using a dialysis solution containing high concentrations of hydrogen produced by electrolysis can reduce the mortality risk and cardiac and cerebrovascular complications in dialysis patients [ 7 ].…”

Molecular Hydrogen as a Medical Gas for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Possible Efficacy Based on a Literature Review

“…Hori et al ( 56 ) indicated that the continuous intake of HRW increased mitochondrial energy production via the expression of these genes and proteins, resulting in an increased peak oxygen consumption during progressive exercise. On the other hand, Mizuno et al reported the ameliorating effects of HRW on mood, anxiety, and autonomic nerve function in daily life ( 82 ), and Hu et al demonstrated that electrolyzed H 2 water attenuated chronic stress due to its antioxidant and anti-inflammatory effects ( 83 ). We also demonstrated in a recent review that the radio-protective and anti-tumor effects of H 2 may involve not only its direct scavenging effects on ·OH, but also its antioxidant and anti-inflammatory effects through the regulation of gene expression as indirect effects ( 31 , 71 ).…”