Alleviation of enhanced oxidative stress and oxygen consumption of l-thyroxine induced hyperthyroid rat liver mitochondria by vitamin E and curcumin

Subudhi, Umakanta; Das, Kajari; Paital, Biswaranjan; Bhanja, Shravani; Chainy, G.B.N.

doi:10.1016/j.cbi.2008.02.005

Cited by 84 publications

(82 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, the increased levels of protein-bound carbonyls in serum of L-thyroxinetreated rats is in agreement with the earlier reports [150,151] suggesting the role of free radicals in the pathogenesis, which demand the need for studies assessing the therapeutic role of antioxidants in hyperthyroidism.…”

Section: Oxidative Stress In Experimental Hyperthyroidism and Hypothysupporting

confidence: 93%

“…Free radicals are produced as a consequence of normal metabolism and their levels and activities are controlled by enzymatic defense mechanisms, such as the SOD, GPx and CAT, and nonenzymatic defense mechanisms, such as ascorbic acid, Vitamin E, and GSH [97,98,99]. Oxidative damage arises when an imbalance occurs in this system, i. e. over-production of free radicals and/or a decrease in antioxidant defence mechanisms [100].…”

Section: Oxidative Stress In Experimental Hyperthyroidism and Hypothymentioning

confidence: 99%

“…Vitamin E is a potent lipid soluble antioxidant in biological systems with the ability to directly quench free radicals and function as membrane stabilizer [237]. It protects and prohibits the propagation of lipid peroxidation, arising from oxidative stress.…”

Section: Antioxidant Statusmentioning

confidence: 99%

See 2 more Smart Citations

Oxidative Stress and Antioxidant Status in Hypo- and Hyperthyroidism

Petrulea¹,

Muresan²,

Duncea³

2012

Antioxidant Enzyme

View full text Add to dashboard Cite

Section: Oxidative Stress In Experimental Hyperthyroidism and Hypothysupporting

confidence: 93%

Section: Oxidative Stress In Experimental Hyperthyroidism and Hypothymentioning

confidence: 99%

See 1 more Smart Citation

Oxidative Stress and Antioxidant Status in Hypo- and Hyperthyroidism

Petrulea¹,

Muresan²,

Duncea³

2012

Antioxidant Enzyme

View full text Add to dashboard Cite

“…Curcumin has been shown to augment antioxidant enzymes in liver of Lthyroxine induced hyperthyroid rats [13]. Curcumin also alleviated oxidative injury in liver mitochondria of hyperthyroidism rats [14]. However, a comparison study examining the relative efficacy of native curcumin and nanoparticle encapsulated curcumin on hyperthyroidism caused liver dysfunction has not been carried out.…”

Section: Introductionmentioning

confidence: 99%

Hepato therapeutic Efficacy of Native Curcumim and Nano –curcumin : A Novel Therapy Against Hyperthyroidism Induced Liver Oxidative and Inflammatory Damage in Rats

Al-Bishri¹

2017

Int. J. Adv. Res. Biol. Sci.

View full text Add to dashboard Cite

Recent works have indicated the beneficial efficacy of using nanocurcumin in addressing poor bioavailability commonly associated with native curcumin. Curcumin has been shown to alleviate hyperthyroidism induced liver dysfunction. Here we carried out a comparative study using both native curcumin and nanocurcumin to verify the superior effects of encapsulation of curcumin in nanomaterials in blunting liver dysfunction in L-thyroxine induced hyperthyroid rats. Native curcumin (NC) and poly (lactide-co-glycolic acid (PLGA) encapsulated curcumin (PNC) significantly increased liver catalase activity and reduced glutathione (GSH) levels and significantly declined malondialdehyde (MDA) levels in hyperthyroid rats. However, rats treated with PNC had significantly better ameliorative effects on these parameters than rats treated with NC. Similarly, PNC showed significantly improved effects in lowering inflammatory mediators including TNF-a, IL-6, VEGF, CRP and caspase protein levels compared to NC in hyperthyroid rats. Serum T3, T4, and TSH levels and liver functional markers including albumin, ALT, ASP and AST were better controlled in PNC treated rats than in NC treated hyperthyroid rats. DNA fragmentation as estimated by comet assay was significantly lower in PNC treated rats than in NC treated rats. Likewise, significantly fewer histopathological and ultrastructural changes were observed in liver tissue in PNC treated hyperthyroid rats. Conclusion: Our work illustrates the capability of PNC to resolve hyperthyroidism induced liver dysfunction and substantiate the findings that beneficial effects of curcumin may be maximized by improving its stability and bioavailability by its encapsulation in nanoparticles.

show abstract

“…Vitamin E is a potent lipid soluble antioxidant in biological systems with the ability to directly quench free radicals and function as membrane stabilizer [16]. It is well known that Vitamin E acts as an antioxidant within cells and the mechanisms which contribute to its efficacy involve the suppression of free radicals and improvement in antioxidant system status [17].…”

Section: Introductionmentioning

confidence: 99%

Effect of Iron, Zinc, Vitamin E and Vitamin C Supplementation on Thyroid Hormones in Rats with Hypothyroidism

Rabeh¹,

El-Ghandour²

2016

IJNFS

View full text Add to dashboard Cite

Abstract:The aim of the study was to investigate the effect of Iron, Zinc, Vitamin C (Vit.C) and Vitamin E (Vit.E) supplementation on thyroid hormones in rats with hypothyroidism. Thirty six rats were divided into two main groups, the first main group (6 rats) was fed on basal diet only. The second main group (30 rat) were injected with 10 mg/kg/day Propylthiouracil (PTU) to induce hypothyroidism, was divided into 5 subgroups: including control positive group that fed on basal diet, and the other subgroups were fed on basal diet supplemented with 40 mg ferric sulphate/kg diet, 200 mg zinc carbonate /kg diet, 250 mg α-tocohperol acetate/kg/B.W. and 250 mg ascorbic acid/kg/B.W. respectively. Blood samples were collected from each rat and were centrifuged to obtain serum. PTU exposed rats showed hypothyroidism with significant (P<0.05) decline in serum FT3 and FT4 levels together with significant (P<0.05) increase in serum TSH level. The supplementation with Iron, Zinc, Vit.E or Vit.C significantly (P<0.05) increased the level of thyroid hormones (FT4 and FT3) and glutathione peroxidase, moreover, the level of TSH was significantly (P<0.05) decreased, compared with control positive group, might be due to their antioxidant properties. Significant improvement in lipid profile as well as liver and kidney functions were observed. It could be suggested that Vitamin C, Vitamin E, Zinc and Iron could be used as a suitable supplementation therapy for hypothyroidism patients.

show abstract

Alleviation of enhanced oxidative stress and oxygen consumption of l-thyroxine induced hyperthyroid rat liver mitochondria by vitamin E and curcumin

Cited by 84 publications

References 52 publications

Oxidative Stress and Antioxidant Status in Hypo- and Hyperthyroidism

Oxidative Stress and Antioxidant Status in Hypo- and Hyperthyroidism

Hepato therapeutic Efficacy of Native Curcumim and Nano –curcumin : A Novel Therapy Against Hyperthyroidism Induced Liver Oxidative and Inflammatory Damage in Rats

Effect of Iron, Zinc, Vitamin E and Vitamin C Supplementation on Thyroid Hormones in Rats with Hypothyroidism

Contact Info

Product

Resources

About