2001
DOI: 10.1074/jbc.m101759200
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Abstract: Understanding the nature of protein grammar is critical because amino acid substitutions in some proteins cause misfolding and aggregation of the mutant protein resulting in a disease state. Amino acid substitutions in phage P22 coat protein, known as tsf (temperature-sensitive folding) mutations, cause folding defects that result in aggregation at high temperatures. We have isolated global su (suppressor) amino acid substitutions that alleviate the tsf phenotype in coat protein (Aramli, L. A., and Teschke, C.… Show more

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Cited by 7 publications
(31 citation statements)
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References 56 publications
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“…For all 3 tsf mutants-D174N, S223F, and F353L-aggregated structures were easily visualized at 33ЊC, consistent with previously published reports (a representative pair is shown in Fig 3A; Teschke 1999; Aramli and Teschke 2001). In addition, tsf :T166I coat proteins readily aggregated while folding at 33ЊC (Teschke 1999;Aramli and Teschke 2001) showing no monomeric bands.…”
Section: Groel Is Not Induced By the F170l Su Substitution In Vivosupporting
confidence: 77%
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“…For all 3 tsf mutants-D174N, S223F, and F353L-aggregated structures were easily visualized at 33ЊC, consistent with previously published reports (a representative pair is shown in Fig 3A; Teschke 1999; Aramli and Teschke 2001). In addition, tsf :T166I coat proteins readily aggregated while folding at 33ЊC (Teschke 1999;Aramli and Teschke 2001) showing no monomeric bands.…”
Section: Groel Is Not Induced By the F170l Su Substitution In Vivosupporting
confidence: 77%
“…The tsf :F170L coat proteins also showed a decrease in rate of monomer loss compared with their tsf parents. Aramli and Teschke (2001) observed that na- Aggregation is decreased for some, but not all, tsf coat proteins when the F170L substitution is also present. The propensity for aggregation while folding was determined by refolding urea-denatured coat proteins by rapid dilution with buffer at various temperatures.…”
Section: Groel Is Not Induced By the F170l Su Substitution In Vivomentioning
confidence: 85%
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