Allergic Photocontact Dermatitis from Promethazine (Phenergan)

Role of <i>in viv</i><i>o</i>- and <i>in vitr</i><i>o</i>-formed Decomposition Products of Sulfanilamides and Phenothiazines in Photoallergy; Relationship of Spectrophotometric Findings to <i>in vivo</i> Reactions

“…Our results (Tables II and III) confirm the well-established finding of St. E pstein and Sams that whereas allergy to sulfanilami des is rare, allergy to phenothiazine derivatives is relatively common (10,19). A sulfanilamide patient may only demonstrate photo allergy, whereas a phenothiazine patient may be either allergic, allergic plus photoallergic, or only photoallergic.…”

“…Sidi et al, Schulz et al as well as E pstein and R o w e previously demon strated the possibility of such photocross-sensitivitics, most suggest ing the similarity between decomposition products as a possible explanation for the phenomenon (10,11,22,25). Patient [20], however, although reacting positively to in vitro irradiated Largactil, reacted negatively to in vitro irradiated Phenergan.…”

Multiple fixed drug eruption caused by promethazine methylene disalicylate as one of the components of pl®combination granules

“…[ 1 ] Promethazine is a first-generation histamine H1-receptor antagonist. [ 2 ] Although promethazine has been used widely in the world, there have been a small number of case reports of drug eruption including photosensitive eruption[ 3 ] and FDE. [ 1 4 ] To the best of our knowledge, this is the third report of FDE caused by promethazine in the English language literature.…”