Allergic contact dermatitis caused by sodium dehydroacetate, not hyaluronic acid, in Ialuset® cream

Contact sensitization to modern dressings: a multicentre study on 354 patients with chronic leg ulcers

“…In the present study, the highest sensitization rate was observed with Ialuset cream ® (45 cases). As recently described by Milpied et al , the main sensitizers were Lanette SX ® and sodium dehydroacetate. Sensitization to Lanette SX ® was attributable to cetostearyl alcohol.…”

Sodium Dehydroacetate

“…Generally known as a well-tolerated molecule with antimicrobial features, broad spectrum with good stability and nonvolatility, 1 it has been recently reported as a possible culprit allergen of allergic contact dermatitis (ACD). 2 A 42-year-old nonatopic woman presented to our attention for the onset of eczematous lesions localized on her legs, mainly surrounding malleolar ulcers. History revealed that she had recurrent ulcers due to deep vein thrombosis associated with factor V Leiden and that, for this reason, she had been using various topical wound healing product.…”

The tissue residues of sodium dehydroacetate used as feed preservative in swine

“…However, studies have reported adverse reactions to Na‐DHA. Na‐DHA, which is used in cosmetic products to reduce the appearance of fine lines, wrinkles, and age spots, may cause contact dermatitis . Additionally, some patients with chronic leg ulcers have reported sensitisation to Na‐DHA .…”

“…Na-DHA, which is used in cosmetic products to reduce the appearance of fine lines, wrinkles, and age spots, 13 may cause contact dermatitis. 14,15 Additionally, some patients with chronic leg ulcers have reported sensitisation to Na-DHA. 16,17 In rats, Na-DHA has anti-coagulant effects and induces haemorrhage due to vitamin K depletion.…”