Allergic Contact Dermatitis After Postsurgical Repair With 2-Octylcyanoacrylate

Hivnor, Chad; Hudkins, Matthew L.

doi:10.1001/archderm.144.6.814

Cited by 57 publications

(35 citation statements)

References 5 publications

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“…Although there are reports about allergic reactions to 2-octyl cyanoacrylate [14], hardly any adverse effects about the Prineo TM wound closure system have been published so far [15]. In our series of 224 procedures in 180 patients, local allergic reactions to the Prineo TM wound closure system were encountered in 4 patients (1.8%).…”

Section: Discussionmentioning

confidence: 60%

Effective Wound Closure With a New Two-Component Wound Closure Device (Prineo™) in Excisional Body-Contouring Surgery: Experience in Over 200 Procedures

et al. 2011

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Background In excisional body-contouring surgery the surgeon is often confronted with time-consuming closure of long wounds. Recently, a new combination of a selfadhering mesh together with a liquid 2-octyl cyanoacrylate adhesive (Prineo TM ; Ethicon, Inc., Somerville, NJ, USA) has been introduced to replace intracutaneous running suture. Methods An observational study was undertaken to evaluate the efficacy of the new wound closure device in excisional body-contouring procedures between January 2008 and November 2010. Wound characteristics were recorded in a prospectively maintained database. Results During the study period, 224 procedures in 180 patients were undertaken. Twenty-seven patients had two subsequent operations and four patients had three subsequent operations. Application of the new device was easy and safe and patient satisfaction with the results was generally high. However, intense local allergic reactions were seen in 4 patients (1.8%), which necessitated early removal and topical corticosteroid treatment. Conclusions Prineo TM enables the surgeon to perform a quick and smooth skin closure, especially in long incisions frequently encountered in excisional body-contouring surgery. The application is fast and easy if basic guidelines are respected. Operating time is saved by eliminating the need for time-consuming intracutaneous running sutures. Removal is easy and painless for the patient. However, there is a potential for local allergic adverse effects of which the surgeon must be aware.

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Section: Discussionmentioning

confidence: 60%

Effective Wound Closure With a New Two-Component Wound Closure Device (Prineo™) in Excisional Body-Contouring Surgery: Experience in Over 200 Procedures

et al. 2011

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“…Despite the widespread use of 2‐octyl‐cyanoacrylates, only a relatively low rate of sensitization has been reported. This could be because of the rapid polymerization of the cyano group upon contact with keratin (3, 4). Others have speculated that the haptens may be enclosed by keratinocytes, making it more difficult for them to trigger an immune response (1).…”

Section: Discussionmentioning

confidence: 99%

Allergic contact dermatitis caused by topical 2‐octyl‐cyanoacrylate

et al. 2013

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“…Known risks of the adhesive such as skin reactions remain generally minor and were explained to the patient. These rare side effects include reports of contact dermatitis and localized foreign body reactions [13][14][15]. All catheters were placed in the operating room using standard sterile technique in the internal jugular or subclavian vein.…”

Section: Methodsmentioning

confidence: 99%

2-Octyl Cyanoacrylate Adhesive for the Prevention of Central Venous Catheter Infections: A Proof of Concept

Dahl

Cohen

Warren

et al. 2017

JACCOA

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Introduction: Colonization of central venous catheters (CVC)s by microorganisms is an event that precedes central line associated bloodstream infection (CLABSI). It is plausible that sealing the skin insertion site of CVCs with 2-octyl cyanoacrylate adhesive may reduce catheter colonization by creating a sterile barrier and minimizing subsequent extraluminal colonization of the catheter. We explored this by evaluating the ability of the skin adhesive to maintain a sealed interface by visual inspection. Materials and Methods:19 enrolled patients underwent application of 2-octyl cyanoacrylate adhesive to the CVC insertion site, followed by daily inspection for visual signs of 2-octyl cyanoacrylate loss of seal integrity with the skin/catheter interface. Additionally, patients were monitored daily for local cutaneous reactions and/or catheter malfunction. After the clinical team removed the catheter, the tip was sent to the microbiology lab for culture via roll plate method.Results: Seal integrity by visual inspection was maintained for a range of 24 days (1-25 days), mean of 6.9 days a median of 7.0 days, and a mode of 7 days. Among the 4 catheters that were cultured in the microbiology laboratory one demonstrated bacterial colonization.Conclusion: 2-octyl cyanoacrylate sealed the skin/catheter insertion site for about 7 days, by visual inspection. Further investigation is necessary to determine if use of this skin adhesive leads to reductions in the rate of catheter colonization and CLABSI.

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Allergic Contact Dermatitis After Postsurgical Repair With 2-Octylcyanoacrylate

Cited by 57 publications

References 5 publications

Effective Wound Closure With a New Two-Component Wound Closure Device (Prineo™) in Excisional Body-Contouring Surgery: Experience in Over 200 Procedures

Effective Wound Closure With a New Two-Component Wound Closure Device (Prineo™) in Excisional Body-Contouring Surgery: Experience in Over 200 Procedures

Allergic contact dermatitis caused by topical 2‐octyl‐cyanoacrylate

2-Octyl Cyanoacrylate Adhesive for the Prevention of Central Venous Catheter Infections: A Proof of Concept

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