Allergic contact dermatitis

Mowad, Christen; Anderson, Bryan; Scheinman, Pamela L.; Pootongkam, Suwimon; Nedorost, Susan T.; Brod, Bruce A.

doi:10.1016/j.jaad.2015.02.1139

Cited by 81 publications

(41 citation statements)

References 106 publications

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“…Patients with AD have both disrupted barrier and immune mechanisms that may potentiate them toward increased rates of allergic and irritant contact dermatitis, and it may be difficult to differentiate these conditions from AD disease activity. 36,37 …”

Section: Introductionmentioning

confidence: 99%

The Long-Term Course of Atopic Dermatitis

Abuabara

Margolis

Langan

2017

Dermatologic Clinics

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Section: Introductionmentioning

confidence: 99%

The Long-Term Course of Atopic Dermatitis

Abuabara

Margolis

Langan

2017

Dermatologic Clinics

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“…Once the detected allergens are removed from the patient's environment, it results in clearing of the dermatitis. 1 One in five individuals from the general population have contact allergy. 2 A study in rural village development community of Nepal showed ACD in 7.7% of the population.…”

Section: Introductionmentioning

confidence: 99%

“…3 ACD is a type IV, delayed type reaction where there is activation of antigen specific T cells in a sensitized individual. 1,4 Patch testing is considered the gold standard in the diagnosis of ACD. 4 It creates an allergic response to non-irritating concentrations of allergens, which are applied directly on the skin.…”

Section: Introductionmentioning

confidence: 99%

Study of Common Allergens in Patients with Allergic Contact Dermatitis: A Hospital Based Study

et al. 2021

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Allergic contact dermatitis (ACD) is one of the most common diseases presenting to the Dermatology department. The one and only method of preventing as well as treating this disease is avoidance of the allergen causing it. The identification of the allergen causing the ACD is possible by performing patch testing. The purpose of this study was to identify common allergens among patients with ACD using Indian standard series (ISS) of patch test. Clinically suspected cases of ACD were included in the hospital based cross-sectional study from January to December 2017. These cases underwent patch testing with the ISS. The study assessed the following variables: sex, age, occupation, site and positive patch test results. There were a total of 58 patients among which, 36.2% were males and 63.8% were females with a mean age of 32.36±12.51 years. Positive patch test reactions were seen in 63.0% of patients. The most common allergens were nickel sulphate (51.4%), fragrance mix (37.8%), potassium dichromate (8.1%), colophony (8.1%) and black rubber mix (8.1%). Among male, most common allergens were fragrance mix (57.1%), nickel sulphate (28.6%) and potassium dichromate (21.4%) while in female, most common allergens were nickel sulphate (65.2%) and fragrance mix (26.1%). In our study, majority of the allergens were positive. Hence, the ISS used in the study might be suitable in the context of Nepalese population. However, further similar studies on large number of patients with multiple allergens are required to determine the exact number of contact allergens prevalent in our population.

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“…Contact hypersensitivity (CHS) is a cutaneous immunological response against a small chemical hapten including 2,4-dinitrofluorobenzene (DNFB), fluorescein isothiocyanate, and oxazolone. Clinically, various allergens such as metals, plants, and drugs can cause allergic contact dermatitis [ 1 , 2 ]. CHS involves two phases: the sensitization phase and the elicitation phase [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

CX3CR1 Deficiency Attenuates DNFB-Induced Contact Hypersensitivity through Skewed Polarization towards M2 Phenotype in Macrophages

Otobe

Hisamoto

Miyagaki

et al. 2020

IJMS

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CX3CL1 can function as both an adhesion molecule and a chemokine for CX3CR1+ cells, such as T cells, monocytes, and NK cells. Recent studies have demonstrated that CX3CL1–CX3CR1 interaction is associated with the development of various inflammatory skin diseases. In this study, we examined CX3CR1 involvement in 2,4-dinitrofluorobenzene (DNFB)-induced contact hypersensitivity using CX3CR1−/− mice. Ear swelling and dermal edema were attenuated after DNFB challenge in CX3CR1−/− mice. Expression of TNF-α, IL-6, and M1 macrophage markers was decreased in the ears of CX3CR1−/− mice, whereas expression of M2 macrophage markers including arginase-1 was increased. Decreased TNF-α and IL-6 expression and increased arginase-1 expression were found in peritoneal macrophages from CX3CR1−/− mice. Furthermore, ear swelling was attenuated by depleting dermal macrophages in wild-type mice to a similar level to CX3CR1−/− mice. These results suggest that CX3CR1 deficiency could induce skewed polarization towards M2 phenotype in macrophages, resulting in attenuation of contact hypersensitivity response.

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Allergic contact dermatitis

Cited by 81 publications

References 106 publications

The Long-Term Course of Atopic Dermatitis

The Long-Term Course of Atopic Dermatitis

Study of Common Allergens in Patients with Allergic Contact Dermatitis: A Hospital Based Study

CX3CR1 Deficiency Attenuates DNFB-Induced Contact Hypersensitivity through Skewed Polarization towards M2 Phenotype in Macrophages

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