Allergic Contact and Photoallergic Contact Dermatitis to Plant and Pesticide Allergens

Mark, Kenneth A.; Brancaccio, Ronald R.; Soter, Nicholas A.; Cohen, David E.

doi:10.1001/archderm.135.1.67

Cited by 61 publications

(23 citation statements)

References 13 publications

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“…The contact irritancy effects such as increased wound secretion, volcano like lesion of Achillea Millefolium have been previously demonstrated. [222324] It has been suggested that Alpha-peroxyachifolid and thujone components of Achillea millefolium may be responsible for contact dermatitis reactions. [24] However, there is no general consensus regarding responsibility of Achillea millefolium for such sensitization response in topical administration.…”

Section: Discussionmentioning

confidence: 99%

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The efficacy of Achilles millefolium topical gel along with intralesional injection of glucantime in the treatment of acute cutaneous leishmaniasis major

et al. 2014

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Background:Leishmaniasis is still one of the endemic parasitic infections in many countries comprising Iran. During the past decades, several medical and surgical approaches have been applied and studied to achieve the best option to treat the cutaneous leishmaniasis in Iran and the world. This study was carried out to evaluate the effect of topical Achilles millefolium in conjunction with intralesional glucantime on acute cutaneous leishmanial lesions.Materials and Methods:sixty patients with confirmed acute cutaneous leishmaniasis were recruited in the study. Patients were randomly allocated into two groups to receive twice daily topical gel of Achilles millefolium 5% (containing 5% poly phenol) (group A) or placebo (group B) for four weeks along with weekly injection of intralesional Glucantime.Results:There was no significant difference between the two groups according to age, gender, and duration of the disease. Also, there was no significant difference in complete and relative cure rates between the two groups (P = 0.35) using Visual Analog Scale (VAS). Application site reactions were occurred in 12 patients including redness in 8 cases in group-A and 2 cases in group-B, severe itching in one case in group-A and increasing wound secretion in another case in group-A (P = 0.014).Conclusions:Given the result of the present study, there is no significant difference in cure rates of lesions between yarrow and placebo topical gels as an adjuvant drugs with intralesional glucantime in treatment of acute cutaneous leishmanial lesions.

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Section: Discussionmentioning

confidence: 99%

“…[24] However, there is no general consensus regarding responsibility of Achillea millefolium for such sensitization response in topical administration. [23]…”

Section: Discussionmentioning

confidence: 99%

The efficacy of Achilles millefolium topical gel along with intralesional injection of glucantime in the treatment of acute cutaneous leishmaniasis major

et al. 2014

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“…AR is still classified as an idiopathic photodermatosis [2, 5, 8]. However, clinical and histological features are essentially eczematous changes suggesting that the AR is a T-cell-mediated type 4 hypersensitivity response against UV-radiation-damaged DNA or similar molecules which may improve during long-term tacrolimus therapy.…”

Section: Discussionmentioning

confidence: 99%

“…AR is associated with atopy [3] and multiple type IV sensitizations such as nickel, cobalt or potassium dichromate and plant allergies [4, 5]. The mechanisms by which contact allergy or contact photoallergy lead to a state of AR remain unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the common treatment modality for AR involves avoidance of UV radiation and if necessary visible light exposure. If the patient is severely affected, installation of UV screening blinds at home and in the car is highly recommended whereas computer and television screens have been estimated to be harmless [5]. Azathioprine, hydroxychloroquine, photochemotherapy, topical and oral corticosteroids or cyclosporine monotherapy have been used successfully to control the inflammation [3, 4, 7].…”

Section: Introductionmentioning

confidence: 99%

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Successful Treatment of Nodular Actinic Reticuloid with Tacrolimus Ointment

Gröne

Kunz²,

Zimmermann³

et al. 2006

Dermatology

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Actinic reticuloid (AR) is the severest clinical variant of chronic actinic dermatitis (CAD) and describes a persistent photoinduced skin disorder often associated with delayed-type hypersensitivity reactions. Histopathologically, AR resembles pseudolymphoma and may also show features of cutaneous lymphoma. In contrast to other UV-induced skin diseases, AR patients show persistent photosensitivity to UV radiation and visible light parallel to permanent changes of skin texture with infiltrated papules and thickened plaques. Therapeutically, CAD is a problematic condition. Daily application of sun protection has to be combined with local or systemic immunosuppression. However, various therapeutic approaches including systemic corticosteroids and other systemic immunosuppressive agents are limited by severe side effects. Tacrolimus, a Streptomyces-derived immunosuppressive macrolide antibiotic and inhibitor of calcineurin, has been proven successful in vari ous inflammatory skin diseases including atopic eczema, allergic contact dermatitis and photodermatoses without undesired side effects. We present a case of severe recalcitrant and nodular chronic actinic dermatitis responding to topically applied tacrolimus (Protopic^®). To avoid further relapses we continued this therapy twice a day over a period of 2 years.

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Occupational Dermatoses

Cohen¹

2001

Patty's Industrial Hygiene

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Diseases of the skin caused by physical or chemical agents or conditions at work continue to outnumber all other work‐associated illnesses. They occur in most occupations and vary from a minor dermatitides to life threatening eruptions and benign and malignant neoplasms. Descriptive titles associated with particular illnesses allow the nosology of illnesses to be easily elucidated, for example, asbestos wart, cement burn, chrome holes, fiber glass itch, hog itch, oil acne, rubber rash, and tar smarts. In view of the variety of skin lesions known to result from contactants within the workplace, the term “occupational dermatoses” is preferred because it includes any abnormality of the skin resulting directly from or aggravated by the work environment.

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Allergic Contact and Photoallergic Contact Dermatitis to Plant and Pesticide Allergens

Cited by 61 publications

References 13 publications

The efficacy of Achilles millefolium topical gel along with intralesional injection of glucantime in the treatment of acute cutaneous leishmaniasis major

The efficacy of Achilles millefolium topical gel along with intralesional injection of glucantime in the treatment of acute cutaneous leishmaniasis major

Successful Treatment of Nodular Actinic Reticuloid with Tacrolimus Ointment

Occupational Dermatoses

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