Allergen-Specific Immunotherapy in Children. Standardizing the Efficacy Evaluation Approaches

Вишнева, Е.А.; Намазова-баранова, Л. С.; Алексеева, А.А.; Эфендиева, К. Е.; Levina, Yu.G.; Tomilova, A.Yu.; Voznesenskaya, N.I.; Волков, К. С.; Баранник, В. А.; Мурадова, О. И.; Selimzyanova, L.R.; Dobrynina, E. A.; Промыслова, Е. А.

doi:10.15690/pf.v12i2.1280

Cited by 3 publications

(4 citation statements)

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“…В целях стандартизации такого анализа в последнее время рекомендовано использовать системный подход: одновременную балльную оценку тяжести клинических проявлений аллергии и количества используемых лекарственных средств (объем потребности в симптоматической терапии). Однако, в ежедневной практике специалиста данный метод, несмотря на свою простоту, широко не используется, оставаясь пока атрибутом лишь клинических исследований [21]. В практике для повседневного использования может быть полезна визуальная аналоговая шкала оценки симптомов.…”

Section: аллергенспецифическая иммунотерапияunclassified

Allergen-Specific Child Immunotherapy: Current State of Affairs

et al. 2016

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The article is devoted to allergen-specific immunotherapy (ASIT) — the only etiopathogenic therapy method for allergic diseases. By promoting the formation of immunological tolerance, ASIT modifies the course of the disease, prevents the occurrence of new or the worsening of existing sensitizations, thereby preventing the development of asthma, which is especially important for pediatric patients. The authors present the mechanism of action and its main features and conditions with regard to achieving the planned effect. Considered are the key contraindications to ASIT, the principles of selecting the appropriate allergen for the treatment and features of its introduction to both children with mono sensitization and children sensitive to the allergen group. Further prospects of research development and existing achievements of this medical technology are mentioned.

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Section: аллергенспецифическая иммунотерапияunclassified

Allergen-Specific Child Immunotherapy: Current State of Affairs

et al. 2016

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“…Moreover, immune response may be morphed into allergic response, especially in allergy-predisposed persons, by the lipids directly associated with allergenic proteins or present in the allergen source; the mechanism may also be launched by microbial contamination [2,3]. Despite the involvement of various pathogenetic mechanisms in the development of allergic inflammation, therapeutic approaches pursue a common goal -attainment of control over the disease [2][3][4][5][6]. The selected drug therapy may feature focus at blocking certain key inflammation mediators and/or broad range of anti-inflammatory effects resulting in blocking activation chain of the key cytokines aggravating and maintaining allergic inflammation.…”

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confidence: 99%

“…Allergic diseases are widespread among children and adolescents, negatively affect physical and psychological condition, social life, school performance and degrade quality of life of both patients and members of their families [2-6, 8, 9]. However, despite high incidence rate, the problem of allergies is often given only little attention: most pediatric patients either do not undergo the necessary therapy or receive only sporadic treatment with symptomatic drugs; self-treatment is widespread along with that [2][3][4][5][6]. One of the reasons of this (not only in Russia) is the absence and/or unavailability (for practicing physicians) of the modern evidence-based recommendations on allergies in children.…”

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confidence: 99%

“…Specific attention is given to proven preventive measures. Timely preventive measures help to prevent both the development of allergic process and disease exacerbation in patients with atopic disease, extend remission and diminish adverse consequences of the disease [2][3][4][5][6]. Traditionally, preventive measures are divided into primary, secondary and tertiary prevention; they are directed at different aspects, but have a common objective [3].…”

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confidence: 99%

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Prevention of Allergies in Children

Вишнёва¹,

Намазова-баранова²

2014

Pediatr. farmakol.

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The article is dedicated to the issue of preventing allergies in children. Increase in the spread of allergic diseases among children and adolescents remains one of the most significant medical and social issues and constitutes a heavy burden for healthcare budgets of many countries around the world. The Federal clinical recommendations must become modern guidelines for practicing clinicians everywhere; these are modern regulatory documents-protocols of medical care rendering to children with various allergic manifestations. The authors substantiate complex approach to the therapy of allergic diseases and determine the role of preventive measures and elimination of trigger effects. The authors traditionally distinguish between primary, secondary and tertiary measures and demonstrate their orientation. They consider the issue of preventing respiratory infections, which often constitute a factor of exacerbation of chronic allergic processes and are one of the frequent causative agents of allergic inflammation. The optimal preventive effect and maximum reduction in the incidence rate of respiratory infections may be achieved by combining vaccination and immune pharmacotherapy.

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An Unstructured Supplementary Service Data System for Daily Tracking of Patient Samples and Diagnostic Results in a Diagnostic Network in Malawi: System Development and Field Trial (Preprint)

Killian¹,

Gibson²,

Kachule³

et al. 2020

Preprint

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BACKGROUND Diagnostics in many low- and middle-income countries are conducted through centralized laboratory networks. Samples are collected from patients at remote point-of-care health facilities, and diagnostic tests are performed at centralized laboratories. Sample transportation systems that deliver diagnostic samples and test results are crucial for timely diagnosis and treatment in such diagnostic networks. However, they often lack the timely and accurate data (eg, the quantity and location of samples prepared for collection) required for efficient operation. OBJECTIVE This study aims to demonstrate the feasibility, adoption, and accuracy of a distributed data collection system that leverages basic mobile phone technology to gather reports on the quantity and location of patient samples and test results prepared for delivery in the diagnostic network of Malawi. METHODS We designed a system that leverages unstructured supplementary service data (USSD) technology to enable health workers to submit daily reports describing the quantity of transportation-ready diagnostic samples and test results at specific health care facilities, free of charge with any mobile phone, and aggregate these data for sample transportation administrators. We then conducted a year-long field trial of this system in 51 health facilities serving 3 districts in Malawi. Between July 2019 and July 2020, the participants submitted daily reports containing the number of patient samples or test results designated for viral load, early infant diagnosis, and tuberculosis testing at each facility. We monitored daily participation and compared the submitted USSD reports with program data to assess system feasibility, adoption, and accuracy. RESULTS The participating facilities submitted 37,771 reports over the duration of the field trial. Daily facility participation increased from an average of 50% (26/51) in the first 2 weeks of the trial to approximately 80% (41/51) by the midpoint of the trial and remained at or above 80% (41/51) until the conclusion of the trial. On average, more than 80% of the reports submitted by a facility for a specific type of sample matched the actual number of patient samples collected from that facility by a courier. CONCLUSIONS Our findings suggest that a USSD-based system is a feasible, adoptable, and accurate solution to the challenges of untimely, inaccurate, or incomplete data in diagnostic networks. Certain design characteristics of our system, such as the use of USSD, and implementation characteristics, such as the supportive role of the field team, were necessary to ensure high participation and accuracy rates without any explicit financial incentives.

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Allergen-Specific Immunotherapy in Children. Standardizing the Efficacy Evaluation Approaches

Cited by 3 publications

References 40 publications

Allergen-Specific Child Immunotherapy: Current State of Affairs

Allergen-Specific Child Immunotherapy: Current State of Affairs

Prevention of Allergies in Children

An Unstructured Supplementary Service Data System for Daily Tracking of Patient Samples and Diagnostic Results in a Diagnostic Network in Malawi: System Development and Field Trial (Preprint)

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