Allergen endotoxins induce T-cell–dependent and non–IgE-mediated nasal hypersensitivity in mice

Iwasaki, Naruhito; Matsushita, Kazunobu; Fukuoka, Ayumi; Nakahira, Masakiyo; Matsumoto, Makoto; Akasaki, Shoko; Yasuda, Koubun; Shimizu, Takeshi; Yoshimoto, Tomohiro

doi:10.1016/j.jaci.2016.03.023

Cited by 29 publications

(11 citation statements)

References 47 publications

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“…On the other hand, conditional pathogens (such as Enterobacteriaceae), which can produce harmful metabolites such as lipopolysaccharide, are increased. Lipopolysaccharide can promote the differentiation of Th2 cells ( Iwasaki et al., 2017 ), which can further promote the production of IgE by B cells, leading to the activation of mast cells to participate in the pathogenesis of CSD ultimately.…”

Section: Resultsmentioning

confidence: 99%

“…Both Enterobacteriaceae and Klebsiella are Gram-negative bacteria, which can produce lipopolysaccharide. Existing studies have shown that lipopolysaccharide can induce nasal hypersensitivity in mice by activating Th2 cells ( Iwasaki et al., 2017 ). These results imply that opportunistic pathogens may also play a role in the pathogenesis of CSD.…”

Section: Discussionmentioning

confidence: 99%

“…Lipopolysaccharide can promote the differentiation of Th2 cells (Iwasaki et al, 2017), which can further promote the production of IgE by B cells, leading to the activation of mast cells to participate in the pathogenesis of CSD ultimately.…”

Section: Hypothetical Model Of Dysbacteriosis Involved In the Pathogenesis Of Csdmentioning

confidence: 99%

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Biomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism

Liu

Peng

Jing

et al. 2021

Front. Cell. Infect. Microbiol.

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BackgroundChronic urticaria (CU) is a chronic inflammatory skin disease associated with Th2 immune response. The two most common subtypes of CU, i.e., chronic spontaneous urticaria and symptomatic dermographism (CSD), often coexist. However, the pathogenesis of CSD is still unclear. Gut microbiota plays an important role in immune-related inflammatory diseases. The purpose of this study was to explore the correlation between gut microbiota and CSD.MethodsA case-control study was conducted on CSD patients as well as gender- and age-matched normal controls (NCs). The 16S ribosomal DNA sequencing of fecal samples was used to detect the gut microbiota of all subjects. QPCR was used to further verify the species with differences between the two groups.ResultsThe alpha diversity of gut microbiota decreased in CSD patients, accompanied by significant changes of the structure of gut microbiota. Subdoligranulum and Ruminococcus bromii decreased significantly in CSD patients and had a potential diagnostic value for CSD according to receiver operating characteristic curve (ROC) analysis. Enterobacteriaceae and Klebsiella were found to be positively correlated with the duration of CSD, while Clostridium disporicum was positively correlated with the dermatology life quality index (DLQI).ConclusionsThe gut microbiota of CSD patients is imbalanced. Subdoligranulum and Ruminococcus bromii are the gut microbiota biomarkers in CSD.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Biomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism

Liu

Peng

Jing

et al. 2021

Front. Cell. Infect. Microbiol.

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“…Moreover, exposure to >2,000 EU LPS/m 3 can cause severe toxic pneumonia 18 , 19 ) . A key component of LPS-mediated inflammation is an enhanced T-helper-type 2 cell (T H 2) reactivity 20 , 21 , 22 ) . Swine farm workers exhibit an immune dysregulation characterized by preferential activation of a T H 2 response 23 ) .…”

Section: Introductionmentioning

confidence: 99%

Altered immune responses in broiler chicken husbandry workers and their association with endotoxin exposure

et al. 2018

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Exposure to bioaerosols in indoor animal farms associates with respiratory illnesses, but little is known about the immune modulation to chicken farmers. This study aimed to compare the general immunity of chicken farmers with those of control subjects with non-agricultural jobs. Blood taken from the farmers and controls was subjected to plasma IgE and IgG subclass measurements. Isolated peripheral blood mononuclear cells (PBMC) were stimulated and cytokine production was measured. Indoor total and respirable dust levels and their endotoxin (LPS) and aflatoxin (AF) levels in the farms were measured. In total, 29 chicken farmers on 19 farms and 14 age- and sex-matched office workers participated. Hematological differences were not observed. The farmers tended to have higher serum IgE and IgG subclass levels with significance for IgG1. The cytokines released by PBMC from farmers indicated skewing toward Type-2 helper T-cell responses: interferon (IFN)-γ:interleukin (IL)-4 and IFNγ:IL-13 ratios were significantly lower than for control PBMC. The farms had 707.1 EU/m3 LPS in total dust, and 15.8 EU/m3 LPS in respirable dust. Farmers exhibited immune skewing towards allergic immune responses that correlated with the LPS levels on their farms. Chicken farmers may be at risk of respiratory allergies due to occupational endotoxin exposure.

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“…However, in the context of ovalbumin (OVA) sensitization, it is not clear whether endotoxin is required to trigger the optimal response. In a series of elegant experiments, 75 it was shown that endotoxin-containing but not endotoxin-free OVA elicited sneezing responses in mice independent of IgE. Local activation of antigen-specific T H 2 cells was required for this response, and this was dependent on TLR4 signaling.…”

Section: Cd4 T Cells and T-cell Subsetsmentioning

confidence: 99%

Advances in mechanisms of allergic disease in 2017

Skevaki

Renz

2018

Journal of Allergy and Clinical Immunology

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This review highlights advances in mechanisms of allergic disease, particularly type 2 innate lymphoid cells, T H 2 lymphocytes, B cells, dendritic cells, microbiome and barrier function, eosinophils, and mast cells. During the last year, considerable progress has been made in the further characterization of type 2 inflammation controlled by both adaptive (T H 2) and type 2 innate lymphoid effector cells. New pathways of lymphocyte activation, trafficking, and recruitment and effector cell mechanisms have been discovered. The plasticity of lymphocyte effector cell responses is another area in which major progress has been achieved. Accumulating evidence will influence both our understanding of allergic disease and our efforts for allergy prevention and treatment.

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Allergen endotoxins induce T-cell–dependent and non–IgE-mediated nasal hypersensitivity in mice

Cited by 29 publications

References 47 publications

Biomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism

Biomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism

Altered immune responses in broiler chicken husbandry workers and their association with endotoxin exposure

Advances in mechanisms of allergic disease in 2017

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