PLoS ONE volume 9, issue 5, Pe98343 2014 DOI: 10.1371/journal.pone.0098343 View full text
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Yuan Gao, Nicole Hamers, Maryam Rakhshandehroo, Ruud Berger, John Lough, Eric Kalkhoven

Abstract: Adipose tissue is a key regulator of energy homestasis. The amount of adipose tissue is largely determined by adipocyte differentiation (adipogenesis), a process that is regulated by the concerted actions of multiple transcription factors and cofactors. Based on in vitro studies in murine 3T3-L1 preadipocytes and human primary preadipocytes, the transcriptional cofactor and acetyltransferase Tip60 was recently identified as an essential adipogenic factor. We therefore investigated the role of Tip60 on adipocyt…

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