All-Photonic Multifunctional Molecular Logic Device

Andréasson, Joakim; Pischel, Uwe; Straight, Stephen D.; Moore, Thomas A.; Moore, Ana L.; Gust, Devens

doi:10.1021/ja203456h

Cited by 313 publications

(291 citation statements)

References 65 publications

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“…Figure 2b shows the equivalent switching circuit of a 1:2 DEMUX, which requires one data input signal and an additional address input to select either output channel to process the input. To date, only several studies associated with a molecular DEMUX have been reported, 11,21,22,[29][30][31] most of which are still based on comprehensive synthetic organic molecules. It is still a great challenge to fabricate a biocompatible DEMUX considering its fundamental and practical significance not only in DNA computing but also in the biomedical field.…”

Section: Resultsmentioning

confidence: 99%

“…Firstly, only fluorescence is utilized as the single signal generation mode, bringing convenience to the operation. In previous studies, the developed DC usually involved several types of optical signals as readouts, such as light absorption, emission or transmission, 21,23,24 making the operation complicated and limiting its further development. Secondly, the utilization of a DNA biomaterial here increases the biocompatibility for potential applications in the biomedical field because each state of a 2-to-4 DC corresponds to a combination, determining whether both, either or neither of the analytes considered as inputs exists in an organism or other complex system.…”

Section: Advanced Logic Circuits For Nonarithmetic Information Procesmentioning

confidence: 99%

“…11,12 In addition to futuristic speculations to construct molecular computers, the biocompatibility here provides additional value in terms of potential applications in biomedical sensing, genetic engineering, intelligent diagnosis and on-demand drug delivery, 2,[13][14][15][16][17][18][19] in comparison with previously related studies based on complex organic molecules or expensive metal complexes. [20][21][22][23][24] …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

DNA-based advanced logic circuits for nonarithmetic information processing

Liu

Dong

et al. 2015

NPG Asia Mater

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DNA has been used as a building block to construct a series of complex logic circuits to perform nonarithmetic functions, including a multiplexer, demultiplexer, encoder and decoder. This is the first time that DNA has been used to cover this broad range of logic circuits, demonstrating the versatility and power of DNA computation to process information on the molecular level. The above logic circuits all share the same DNA platform, indicating the great prospects for DNA computation. The enzyme-free system developed here provides a novel prototype for the design of DNA-based, high-level molecular logic circuits. Considering its biocompatibility, DNA computation could find potential applications in biological and biomedical fields in the not-too-distant future.

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Section: Resultsmentioning

confidence: 99%

Section: Advanced Logic Circuits For Nonarithmetic Information Procesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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DNA-based advanced logic circuits for nonarithmetic information processing

Liu

Dong

et al. 2015

NPG Asia Mater

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“…7 We now use pH sensors to lift the field of molecular logic-based computation [8][9][10][11][12][13] to a much higher plane by demonstrating human-level computing by small molecules. Important advances in the level of complexity of molecular logic have been achieved by using chemical species to link gates, [14][15][16][17] by employing multi-component photochromics, 18,19 by using cuvet arrays, 20,21 and by the use of algorithmic pipeting protocols in multiwell plates. 22 We present the first instance of small synthetic molecules performing a major computation that humans do often during each waking hour.…”

Section: Supporting Information Placeholdermentioning

confidence: 99%

Building pH Sensors into Paper-Based Small-Molecular Logic Systems for Very Simple Detection of Edges of Objects

Ling¹,

Naren

Kelly³

et al. 2015

J. Am. Chem. Soc.

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Genetically engineered bacteria and reactive DNA networks detect edges of objects, as done in our retinas and as also found within computer vision. We now demonstrate that simple molecular logic systems (a combination of a pH sensor, a photo acid generator, and a pH buffer spread on paper) without any organization can achieve this relatively complex computational goal with good fidelity. This causes a jump in the complexity achievable by molecular logic-based computation and extends its applicability. The molecular species involved in light dose-driven "off−on−off" fluorescence is diverted in the "on" state by proton diffusion from irradiated to unirradiated regions where it escapes a strong quencher, thus visualizing the edge of a mask.

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“…Photochromic switches have been often exploited for these purposes. [12][13][14][15] However, chemically-addressable systems and redox-switchable molecular devices were also used for the demonstration of molecular keypad locks [16][17][18][19] and flip-flops. 20,21 Surprisingly, the exploitation of supramolecular host-guest phenomena for the demonstration of keypad lock functions has no precedence in the literature.…”

mentioning

confidence: 99%

A supramolecular keypad lock

et al. 2015

Self Cite

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The reversible photoswitching between an anthracene derivative and its [4+4] dimer, using the template effect of the CB8 macrocycle, was demonstrated. This example of supramolecular chemistry in water was harnessed to demonstrate the operation of a keypad lock device that is driven by means of light and chemicals as inputs.The use of molecular species for achieving information processing of chemical, photonic or electrochemical signals according to the principles of binary coding (0 and 1) and Boolean language continues to receive wide attention. [1][2][3] The challenge of achieving the design of molecules that are capable of a predetermined logic operation has received important backup from smart applications of molecular logic gates in sensing, drug delivery, theranostics, and materials chemistry. [4][5][6][7][8][9][10] Among the different logic operations, those that imply a memory function belong to the most demanding ones in terms of their chemical design. 11 This type of logic, known as sequential logic, results in differentiated outputs depending on the input history of the device. Current research activities along these lines have their focus on the implementation of flip-flops and molecular keypad locks. Photochromic switches have been often exploited for these purposes. [12][13][14][15] However, chemically-addressable systems and redox-switchable molecular devices were also used for the demonstration of molecular keypad locks [16][17][18][19] and flip-flops. 20,21 Surprisingly, the exploitation of supramolecular host-guest phenomena for the demonstration of keypad lock functions has no precedence in the literature. In recent reports host-guest complexes with cucurbit [7]uril (CB7) and cucurbit [8]uril (CB8) were used to demonstrate the reconfigurable and resettable operation of logic gates in aqueous solution. 22,23 Cucurbiturils have drawn much attention for their very high binding constants of cationic guests (up to 10 17 M À1 ) 24 and their supramolecular application potential with a strong focus on biological and pharmacological contexts, and analytical problems is beginning to reveal. [25][26][27][28][29][30][31][32][33][34][35] In the present work we take advantage of the specific complexation properties of the CB8 macrocycle. Unlike the smaller homologues CB6 and CB7, that commonly offer space for only one guest molecule, the larger CB8 often accommodates two guests and the resulting complexes may feature new emission properties (e.g., excimer fluorescence) or lead to fluorescence self-quenching. [35][36][37][38] Additionally, the resulting pre-organization of the two guests may facilitate intracomplex photoreactions that would not happen at the dilute concentrations of the free dye molecules. [38][39][40] In a wider context, host-templated photodimerizations have been used in the design of photoswitchable supramolecular polymers. [40][41][42] Herein we designed the anthracene derivative 1 (see the ESI † for details of the synthesis and Scheme 1 for the structure) which contains a positively ...

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All-Photonic Multifunctional Molecular Logic Device

Cited by 313 publications

References 65 publications

DNA-based advanced logic circuits for nonarithmetic information processing

DNA-based advanced logic circuits for nonarithmetic information processing

Building pH Sensors into Paper-Based Small-Molecular Logic Systems for Very Simple Detection of Edges of Objects

A supramolecular keypad lock

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