Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study

Peremiquel-Trillas, Paula; Benavente, Yolanda; Martín-Bustamante, Mayte; Casabonne, Delphine; Pérez‐Gómez, Beatriz; Gómez‐Acebo, Inés; Oliete-Canela, Anna; Diéguez-Rodríguez, Marta; Tusquets, Ignasi; Amiano, Pilar; Mengual, Lourdes; Ardanáz, Eva; Capelo, Rocío; Torre, Antonio José Molina de la; Trejo, Dolores Salas; Fernández‐Tardón, Guillermo; Lope, Virginia; Jiménez-Moleón, José-Juan; Marcos‐Gragera, Rafael; Dierssen-Sotos, Trinidad; Azpiri, Mikel; Muñoz, Montse; Guevara, Marcela; Fernández‐Villa, Tania; Molina-Barceló, Ana; Aragonés, Núria; Pollán, Marina; Castaño‐Vinyals, Gemma; Alguacil, Juan; Kogevinas, Manolis; Sanjosé, Sílvia de; Costas, Laura

doi:10.1016/j.envint.2018.12.007

Cited by 25 publications

(13 citation statements)

References 52 publications

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“…BC and PC, the most common neoplasms, are estrogen-dependent tumors. Xenoestrogens (XEs), natural or synthetic, are endocrine-disrupting chemicals (EDCs) found in the environment, food, air, and cosmetics which interact with estrogen receptors and impact both metabolic pathways and the immune system [ 165 , 166 ]. Prolonged exposure to EDCs that interact with steroid receptors impacts the cellular mechanisms and, hence, can drive tumorigenesis.…”

Section: Role Of Pgs In Hormone-dependent Cancer Growth Metastasimentioning

confidence: 99%

“…Various environmental factors contribute to the disruption of these intricate mechanisms, among which the continuous exposure of humans to endocrine-disrupting chemicals (EDCs) can trigger estrogen-dependent tumors [ 166 ]. Moreover, due to the link between the endocrine and immune system, EDCs impact the potency of the immune elements leading to various dysfunctions [ 177 ].…”

Section: The Contribution Of Pgs To the Immunobiology Of Hormone-dmentioning

confidence: 99%

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Proteoglycans in the Pathogenesis of Hormone-Dependent Cancers: Mediators and Effectors

Tzanakakis

Giatagana

Kuskov

et al. 2020

Cancers

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Hormone-dependent cancers exhibit high morbidity and mortality. In spite of advances in therapy, the treatment of hormone-dependent cancers remains an unmet health need. The tumor microenvironment (TME) exhibits unique characteristics that differ among various tumor types. It is composed of cancerous, non-cancerous, stromal, and immune cells that are surrounded and supported by components of the extracellular matrix (ECM). Therefore, the interactions among cancer cells, stromal cells, and components of the ECM determine cancer progression and response to therapy. Proteoglycans (PGs), hybrid molecules consisting of a protein core to which sulfated glycosaminoglycan chains are bound, are significant components of the ECM that are implicated in all phases of tumorigenesis. These molecules, secreted by both the stroma and cancer cells, are crucial signaling mediators that modulate the vital cellular pathways implicated in gene expression, phenotypic versatility, and response to therapy in specific tumor types. A plethora of deregulated signaling pathways contributes to the growth, dissemination, and angiogenesis of hormone-dependent cancers. Specific inputs from the endocrine and immune systems are some of the characteristics of hormone-dependent cancer pathogenesis. Importantly, the mechanisms involved in various aspects of cancer progression are executed in the ECM niche of the TME, and the PG components crucially mediate these processes. Here, we comprehensively discuss the mechanisms through which PGs affect the multifaceted aspects of hormone-dependent cancer development and progression, including cancer metastasis, angiogenesis, immunobiology, autophagy, and response to therapy.

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Section: Role Of Pgs In Hormone-dependent Cancer Growth Metastasimentioning

confidence: 99%

Section: The Contribution Of Pgs To the Immunobiology Of Hormone-dmentioning

confidence: 99%

Proteoglycans in the Pathogenesis of Hormone-Dependent Cancers: Mediators and Effectors

Tzanakakis

Giatagana

Kuskov

et al. 2020

Cancers

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“…Alkylphenolic compounds frequently occur in detergents or degreasers used in the food industry, in specialty paints, and in pesticides, explaining how painters, farm workers and people working in the restaurant service industry were exposed to these compounds in our study 16,17 . Even though individuals may also come in contact with these chemicals through nutrition, drinking water, cosmetics, and cleaning products, the most significant exposure happen in individuals working with specialty paints and pesticides 17 …”

Section: Discussionmentioning

confidence: 73%

“…Parental alkylphenolic exposure has been linked to the occurrence of CHDs of the offspring as a whole, and to certain CHD subtypes as well, such as coarctation of the aorta, ventricular septal defects, pulmonary valve stenosis, or patent ductus arteriosus 5,22,24 . Alkylphenolic compounds frequently occur in detergents or degreasers used in the food industry, in specialty paints, and in pesticides, explaining how painters, farm workers and people working in the restaurant service industry were exposed to these compounds in our study 16,17 . Even though individuals may also come in contact with these chemicals through nutrition, drinking water, cosmetics, and cleaning products, the most significant exposure happen in individuals working with specialty paints and pesticides 17 …”

Section: Discussionmentioning

confidence: 77%

“…For example, polychlorinated organic compounds are frequently used in electronic devices, oils for hydraulic devices and motors, paints, adhesives, or plastics 15 . Alkylphenolic compounds on the other hand usually occur in domestic and industrial degreasers, paints, and pesticides, while phthalates and biphenolic compounds are common ingredients of plastics 16‐19 . Biphenolic compounds, furthermore, are also used in dental sealants and dental composite materials as well 20 .…”

Section: Introductionmentioning

confidence: 99%

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Congenital heart diseases and parental occupational exposure in a Hungarian case‐control study in 1997 to 2002

Fazekas-Pongor

Csáky-Szunyogh²,

Fekete

et al. 2020

Congenital Anomalies

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The etiology of congenital heart diseases is not fully understood yet, however, endocrine disrupting chemicals may have a causative role in their development. The purpose of our study was to examine the association between congenital heart diseases and periconceptional parental occupational exposure to endocrine disrupting chemicals. In our Hungarian population‐based case‐control study, we examined 2263 live born cases with any congenital heart disease and 6789 matched controls selected between years 1997 to 2002. Occupational exposure was assessed with a job‐exposure matrix developed for endocrine disrupting chemicals. Conditional multiple logistic regression analyses were performed to test associations between parental occupational exposure to endocrine disrupting chemicals and congenital heart diseases of the offspring as a whole and by congenital heart disease subtypes. The prevalence of exposure to endocrine disrupting chemicals was 4.5% for both case and control mothers and 19.1% and 19.4% for case and control fathers, respectively. We found a positive association between paternal pesticide (adjusted odds ratio = 1.66, 95% confidence interval: 1.03‐2.69) and alkylphenolic compound exposure (adjusted odds ratio = 1.95, 95% confidence interval: 1.30‐2.93) and the development of patent ductus arteriosus in the offspring. Alkylphenolic compound exposure occurred among painters, famers, and those working in the food service industry, while pesticide exposure occurred predominantly among farm workers. We identified that certain occupations may increase the occurrence of certain congenital heart disease phenotypes in the offspring. By paying closer attention to those working in these areas, antenatal detection rates of congenital heart diseases may be improved.

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The Role of the Environment in Hormone-Related Cancers

Mlynarčíková

Scsuková²

2022

Endocrinology

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Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study

Cited by 25 publications

References 52 publications

Proteoglycans in the Pathogenesis of Hormone-Dependent Cancers: Mediators and Effectors

Proteoglycans in the Pathogenesis of Hormone-Dependent Cancers: Mediators and Effectors

Congenital heart diseases and parental occupational exposure in a Hungarian case‐control study in 1997 to 2002

The Role of the Environment in Hormone-Related Cancers

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