Alkaloids of <i>Fagraea fragrans</i> Roxb

Wan, Alfred S. C.; Chow, Yimmy

doi:10.1111/j.2042-7158.1964.tb07497.x

Cited by 16 publications

(9 citation statements)

References 3 publications

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“…The presence of alkaloids in the leaves of F. fragrans has been reported. 33 At the beginning of the flowering season (May-June), the percentage of alkaloids content in the leaves has been found to be highest (0.32%) and lowest (0.005%) after fruiting had occurred (October-November). The presence of 0.10% alkaloids has been reported from the ripe fruits.…”

Section: Resultsmentioning

confidence: 97%

“…The presence of 0.10% alkaloids has been reported from the ripe fruits. 33 An alkaloid gentianine has been isolated from the leaves and fruits of F. fragrans. 33 However, this alkaloid isolated from other species is reported to have various pharmacological activities including the potential anti-inflammatory effect on experimental animals.…”

Section: Resultsmentioning

confidence: 99%

“…33 An alkaloid gentianine has been isolated from the leaves and fruits of F. fragrans. 33 However, this alkaloid isolated from other species is reported to have various pharmacological activities including the potential anti-inflammatory effect on experimental animals. 34 Stigmasterol and β-sitosterol have been isolated in a pure state from the stem bark of this plant.…”

Section: Resultsmentioning

confidence: 99%

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Phytochemical Characterization of Extracts from Fagraea Fragrans and Juglans Regia by GC-MS Analysis

Pillai

Young

2022

Fine Chemical Engineering

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Fagraea fragrans and Juglans regia have several therapeutic applications. The present study aimed to analyze the phytochemical compositions of a methanolic crude extract from the stem bark of F. fragrans and an oily liquid from a chloroform extract of seeds of J. regia. Approximately, 220 g of methanolic crude extract (yield = ca. 5%) was obtained from the stem bark of F. fragrans from hot-solvent extraction, and approximately, 45 g of chloroform oily liquid (yield = ca. 1.5%) was obtained from the seeds of J. regia by maceration technique. The phytochemical compositions of these two extracts were analyzed separately by injecting an aliquot of 1.0 μL solution of each extract prepared in hexane to a GC-MS instrument fitted with a DB-5 column of the dimension 50 m × 0.25 mm, i.d., 0.25 μm film thickness. The presence of fourteen components, including fragrant aldehydes and bioactive sterols, was identified in the methanolic crude extract and the presence of eight components, including fatty acids, fatty esters, and γ-tocopherol, was identified in the chloroform oily liquid. For the first time, we report the presence of γ-tocopherol (3.46%), n-hexanoic acid (1.26%), ethyl hexadecanoate (4.70%), ethyl oleate (6.59%), and a high content of ethyl linoleate (29.93%) in this chloroform oily liquid. From this study, we concluded that F. fragrans and J. regia have bioactive compounds of pharmaceutical importance. Therefore, these compounds can be extracted from these plants for therapeutic applications.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Phytochemical Characterization of Extracts from Fagraea Fragrans and Juglans Regia by GC-MS Analysis

Pillai

Young

2022

Fine Chemical Engineering

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“…Phytochemical works were conducted on many parts of Fagraea Fragrans Roxb, Loganiaceae, such as isolated gentianine for antimalarial and antiamoebic from leaves, fruits, and twigs [1,2], and isolated fagraldehyde for antiplasmodial from bark and leaves [3]. The secondary metabolites of F. fragrans fruits have also mapped recently [4] and now we report three simple alkaloids from these fruits in order to boost our people and industries to use these for both medicinal and phytocosmetics.…”

Section: Introductionmentioning

confidence: 93%

Alkaloids of Fagraea fragrans (Tembesu) Fruits

Basir¹,

Miksusanti²,

Susilawati³

et al. 2020

IJFAC

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The aim of this paper is to visualize the alkaloids of Fagraea fragrans fruits therefore the fruits can be scientifically used as herb traditional medicines and phytocosmetics. Three alkaloids have successfully been identified from those Fagraea fragrans fruits, Loganiaceae. They are gentialutine, gentianine, and isaindigotone. The alkaloids were alternately explored by means of ether and 2% H2SO4 extractions. The sulphuric acid phase was naturalized with ammonium chloride and then extracted with ethyl acetate. The residue were then subjected to silica gel G60 (70-230 mesh) column chromatography and eluted with 40% ethyl acetate in n-hexane. The LC-MS spectral of alkaloids gave the protonated molecular ion peaks at m/z (r.t. minute) = 150.08 (1.39), 176.06 (4.80), and 351.37 (5.24) respectively

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“…Literature shows that little is known concerning the chemical composition of this species or its biological activities. Studies on other species of the genus Fagraea revealed diverse compound families such as alkaloids, secoiridoid glycosides, coumarins, flavanols, other phenols, and lignans in the stem bark, roots, and leaves [13][14][15][16][17][18][19][20][21]. The only chemistryrelated study on the fruits is of F. fragrans Roxb.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Hair Dermal Papilla Cells Induction by Fagraea berteroana, a Tree of the Marquesan Cosmetopoeia (French Polynesia)

Hughes

Chazaud

et al. 2021

Cosmetics

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Fagraea berteroana is a tree used in traditional medicine in various islands of the South Pacific. Here, we studied its hair growth-inducing properties as suggested by one of its Marquesan ethno-uses in haircare. The ethyl acetate extract of the fruits of F. berteroana (FEAE) and four resulting fractions (FEAE-F0, FEAE-F1, FEAE-F2, and FEAE-F3) were tested on hair follicle dermal papilla cells to determine their cell proliferative activity. Furthermore, RT-qPCR analysis enabled gene modulation analysis, while immunostaining of the β-catenin protein was used to follow protein regulation. We found that the plant extracts induced a controlled, dose-dependent cell proliferation. FEAE-F0 simultaneously down-regulated Bone Morphogenetic Protein 2 (BMP2) mRNA expression and upregulated Cyclin-D1 (CCND1) gene expression, which suggests an involvement in the regulation of the Wnt and Transforming Growth Factor beta (TGFβ) pathways that control the hair cycle. FEAE-F0 exhibited a 1.34-fold increase of nuclear β-catenin protein. This is indicative of an active hair growth state. Thus, we conclude that FEAE-F0 could be an innovative candidate in hair care, which opens interesting leads to promote the Marquesan cosmetopoeia.

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Alkaloids of Fagraea fragrans Roxb

Abstract: The major alkaloid of the leaves and fruits of Fagraea fragrans Roxb. has been isolated and shown to be 4-(2-hydroxyethyl)-5-vinyl nicotinic acid lactone identical with gentiamine.

Cited by 16 publications

References 3 publications

Phytochemical Characterization of Extracts from Fagraea Fragrans and Juglans Regia by GC-MS Analysis

Phytochemical Characterization of Extracts from Fagraea Fragrans and Juglans Regia by GC-MS Analysis

Alkaloids of Fagraea fragrans (Tembesu) Fruits

In Vitro Hair Dermal Papilla Cells Induction by Fagraea berteroana, a Tree of the Marquesan Cosmetopoeia (French Polynesia)

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