Alkaline shock protein 23 (Asp23)‐controlled cell wall imbalance promotes membrane vesicle biogenesis in Staphylococcus aureus
Jia Li,
Keting Zhu,
Chao Li
et al.
Abstract:Membrane vesicles (MVs) are produced by species across all domains of life and have diverse physiological functions as well as promising applications. While the mechanisms for vesiculation in Gram‐negative bacteria are well‐established, the genetic determinants and regulatory factors responsible for MV biogenesis in Gram‐positive bacteria remain largely unknown. Here, we demonstrate that a Q225P substitution in the alternative sigma factor B (SigB) triggers MV production in Staphylococcus aureus strain Newman … Show more
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