Alkaline Phosphatase in Alopecia Areata

Kopf, Alfred W.

doi:10.1001/archderm.1957.01550210012003

Cited by 21 publications

(5 citation statements)

References 15 publications

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“…34 ALKP levels were lower in the patients with the universalis form compared to those with the localized form, which could be due to the presence of this enzyme in the hair follicles and its role in the growth and metabolism of hair. 35 Our study showed that vitamin D and CRP levels are inversely correlated in patients with AA and that patients with vitamin D levels under 15 and CRP levels over 16.…”

Section: Discussionsupporting

confidence: 48%

“…With regard to this finding, one study found an inverse correlation between vitamin D and CRP levels in newborns 33 ; in another study, low vitamin D status was associated with higher biomarkers of inflammation, including CRP levels 34 . ALKP levels were lower in the patients with the universalis form compared to those with the localized form, which could be due to the presence of this enzyme in the hair follicles and its role in the growth and metabolism of hair 35 . Our study showed that vitamin D and CRP levels are inversely correlated in patients with AA and that patients with vitamin D levels under 15 and CRP levels over 16.5 are more prone to alopecia universalis, which is consistent with a case control study by Rehman et al that showed vitamin D levels have a significant inverse correlation with the severity of AA as assessed by SALT score 30 …”

Section: Discussionmentioning

confidence: 98%

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Inverse correlation between vitamin D and CRP levels in alopecia areata: A pilot study

Mokhtari,

Ganjei,

Yazdanpanah

et al. 2023

J of Cosmetic Dermatology

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IntroductionAlopecia areata (AA) is an autoimmune non‐scarring hair loss. The role of micronutrients such as iron, zinc, and vitamins, especially vitamin D, on the natural hair cycle is well defined in literature. This study aims to evaluate the correlation between vitamin D and CRP levels in patients with alopecia areata.MethodsThis cross‐sectional study was performed from beginning of October 2020 until end of December 2021. Alopecia areata patients over 18 years of age gave their written consent to participate in the study. The severity of the patients' disease was assessed using the Severity of Alopecia Tool. Serum vitamin D and CRP levels were measured and CBC and LFT were also performed.ResultsThere were significant differences between the patients with the localized form of AA and its universal form in the following variables: Vitamin D levels, SALT score, WBC, ALKP, and CRP. There was also a significant inverse correlation between CRP and vitamin D levels (p < 0.0001).ConclusionVitamin D deficiency is associated with higher CRP levels, and patients with low serum vitamin D and high CRP levels are at a higher risk of developing the universalis form of AA; therefore, these patients should undergo more aggressive treatments.

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 98%

Inverse correlation between vitamin D and CRP levels in alopecia areata: A pilot study

Mokhtari,

Ganjei,

Yazdanpanah

et al. 2023

J of Cosmetic Dermatology

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“…The PI zone of the insect brain contains several neuronal cell bodies, some of which are neurosecretory (19,20). In Drosophila, their identity and number are still poorly characterized.…”

Section: Ingestion Of Fluvastatin a Jh Biosynthesis Inhibitor Mimicmentioning

confidence: 99%

Neuroendocrine control of a sexually dimorphic behavior by a few neurons of the pars intercerebralis in Drosophila

Belgacem

Martin

2002

Proc. Natl. Acad. Sci. U.S.A.

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In Drosophila, locomotor activity is sexually dimorphic and the brain area controlling this dimorphism has been mapped. The neurons of the pars intercerebralis (PI) have been suggested to participate in such differences between males and females. However, the precise physical nature of the dimorphism, the identity of the PI neurons involved, and the nature of the neuronal signal coding the dimorphism remain unknown. In this study, we used a video-tracking paradigm to characterize further the pattern of locomotor activity in Drosophila. We show that the number of activity͞inactivity periods (start͞stop bouts) is also sexually dimorphic, and that it can be genetically feminized in males. Moreover, the transplantation of PI neurons from a female, or of feminized PI neurons from a donor male into a receiver wild-type male is sufficient to induce the feminization of locomotor behavior, confirming that this tiny cluster of Ϸ10 neurons is directly responsible for the sexual dimorphism in locomotor activity. Finally, feeding males with fluvastatin, a juvenile hormone (JH) inhibitor, also led to start͞stop feminization, and this effect is reversible by the simultaneous application of methoprene, a JH analog, suggesting the existence of a neuroendocrine control, by JH, of such behavioral dimorphism. Invertebrates and vertebrates show sexually dimorphic behaviors, and it has been suggested that males and females differ in the brain structures controlling such behavioral differences (1-4). Such sex differences have often been used as a way of studying how brain structure contributes to brain function. However, although many sexually dimorphic neural structures have been described (2-4), very few studies have yet demonstrated the direct involvement of a brain structure in a sexually dimorphic behavior (5, 6) and still less a behavior expressed in a nonsexual context. We recently showed that Drosophila locomotor activity is sexually dimorphic (7) outside any sexual context. We could abolish this behavioral dimorphism and create males with a female-like activity profile by genetic manipulations (8). Briefly, we used a UAS-transformer transgene (UAS-tra; ref. 9), the feminizing action of which has been shown to be cell-autonomous (10-12), under the control of different brainspecific enhancer trap P[Gal4] lines. This first study suggested strongly that a few neurons located in the mid-anterior part of the pars intercerebralis (PI) might participate in the control of this sexually dimorphic behavior (8). However, because in this previous study the fly was observed in a small tube, the locomotor activity was indirectly quantified when the fly crossed an infra-red light-gate. As a result, the precise locomotor parameters that accounted for the sexual difference could not be elucidated. Furthermore, the involvement of the PI neurons was indirectly deduced on the basis of a genetic ablation, and the molecular mechanisms linking those few PI neurons to the sexually dimorphic behavior remained to be identified. In this study, we develo...

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“…We first investigated whether the Edelweiss extract was able to modulate hair growth ex vivo. To this end, hair shaft production was measured using bright‐field images, and microscopic hair cycle staging and scoring was performed by employing Ki‐67/TUNEL immunostaining and the Masson–Fontana histochemistry [30].…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, hair regeneration, or maintenance of anagen, is dependent on dermal papilla inductivity [25,26]. The latter is sustained by the expression of the extracellular matrix protein, versican and the expression and activity of alkaline phosphatase in the hair follicle dermal papilla [27][28][29][30]. Notably, dermal papilla inductivity is linked to the production of Wnt molecules that stimulate the proliferation of hair matrix keratinocytes [27,31,32].…”

Section: Introductionmentioning

confidence: 99%

An extract of Leontopodium alpinum inhibits catagen development ex vivo and increases hair density in vivo

Campiche¹,

Riche

Edelkamp

et al. 2022

Intern J of Cosmetic Sci

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Objectives: Hair loss and reduction in hair volume are hallmarks of hair disorders, such as telogen effluvium, or male or female pattern hair loss, and hair ageing, which can cause severe distress in both men and women. Common antihair loss drugs carry some side effects; therefore, novel, safer approaches targeting milder phenotypes are highly advocated. In this context, we investigated an extract of the alpine plant Edelweiss, Leontopodium alpinum var. Helvetia, for its ability to modulate hair follicle (HF) growth ex vivo and inhibit hair loss while increasing hair regeneration in vivo.Methods: Human amputated HFs were microdissected from three donors, two women and one man, and cultured ex vivo for 6 days. After treatment with 0.001% Edelweiss extract (EWDE), we investigated hair shaft production and anagen/catagen conversion, and measured known parameters associated with hair growth, that is hair matrix keratinocyte proliferation and apoptosis, dermal papilla inductivity, and growth factors, by quantitative (immuno)histomorphometry. To assess the anti-hair loss potential of the alpine plant compound, we performed a randomized, placebo-controlled human study enrolling Caucasian women and men, aged 18 to 65 years, with normal hair loss. After 5 months' daily use of an extract containing leave-on serum, we analysed hair density and anagen-to-catagen/telogen ratio by the Trichogram analysis. Results:Our results revealed a significant prolongation in the anagen phase in HFs treated with 0.001% Edelweiss, as indicated by an increase in HFs remaining in anagen and a significant decrease in hair cycle score. In line with this effect, EWDE significantly stimulated hair matrix (HM) keratinocyte proliferation, and dermal papilla inductivity, as shown by a significant up-regulation of versican expression and alkaline phosphatase activity, and a tendential increase in FGF7 immunoreactivity in the dermal papilla of all HFs or only anagen VI HFs.Corroborating the ex vivo results, we observed a significant increase in growingThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Alkaline Phosphatase in Alopecia Areata

Cited by 21 publications

References 15 publications

Inverse correlation between vitamin D and CRP levels in alopecia areata: A pilot study

Inverse correlation between vitamin D and CRP levels in alopecia areata: A pilot study

Neuroendocrine control of a sexually dimorphic behavior by a few neurons of the pars intercerebralis in Drosophila

An extract of Leontopodium alpinum inhibits catagen development ex vivo and increases hair density in vivo

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