Alignment of muscle precursor cells on the vertical edges of thick carbon nanotube films

Holt, Ian; Gestmann, Ingo; Wright, Andrew

doi:10.1016/j.msec.2013.06.017

Cited by 6 publications

(4 citation statements)

References 34 publications

(50 reference statements)

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“…Furthermore, Holt et al. demonstrated that VACNT can be used as a biocompatible substrate for directional alignment of mouse muscle cells where, similar to neuron cells, the cells grow on the edges of the nanotubes . Lastly, there are reports of culturing retinal cells on VACNT as a dual scaffold and implantable MEA. , It was reported that the mechanical strength of VACNT was critical for retinal neurite outgrowth and the high surface area made for a high-quality electrode.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Vertically Aligned Carbon Nanotubes as a Unique Material for Biomedical Applications

Kohls

Ditty

Dehghandehnavi

et al. 2022

ACS Appl. Mater. Interfaces

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Vertically aligned carbon nanotubes (VACNTs), a unique classification of CNT, highly oriented and normal to the respective substrate, have been heavily researched over the last two decades. Unlike randomly oriented CNT, VACNTs have demonstrated numerous advantages making it an extremely desirable nanomaterial for many biomedical applications. These advantages include better spatial uniformity, increased surface area, greater susceptibility to functionalization, improved electrocatalytic activity, faster electron transfer, higher resolution in sensing, and more. This Review discusses VACNT and its utilization in biomedical applications particularly for sensing, biomolecule filtration systems, cell stimulation, regenerative medicine, drug delivery, and bacteria inhibition. Furthermore, comparisons are made between VACNT and its traditionally nonaligned, randomly oriented counterpart. Thus, we aim to provide a better understanding of VACNT and its potential applications within the community and encourage its utilization in the future.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Vertically Aligned Carbon Nanotubes as a Unique Material for Biomedical Applications

Kohls

Ditty

Dehghandehnavi

et al. 2022

ACS Appl. Mater. Interfaces

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“…Graphene's highly organized crystalline structure results in unique physicochemical properties, namely a high elastic modulus, optical transmittance, and electrical and thermal conductivities. [86,87] These properties have led www.advancedsciencenews.com www.advhealthmat.de Holt et al [53] MWNT Pristine, acid functionalized, amine functionalized…”

Section: Properties Of Graphene Family Nanomaterialsmentioning

confidence: 99%

“…studied the growth of C2C12 mouse myoblasts on highly aligned, small diameter (10 nm) SWNT mats. [ 53 ] Cells were observed to grow in a unidirectional manner on horizontally aligned arrays, though mechanical wiping of the mats diminished bioactivity, perhaps due to the compact nature of the nanotubes after this treatment.…”

Section: Properties Of Carbon Nanotubesmentioning

confidence: 99%

Nanomaterial Additives for Fabrication of Stimuli‐Responsive Skeletal Muscle Tissue Engineering Constructs

Farr

Hogan

Mikos

2020

Adv Healthcare Materials

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Volumetric muscle loss necessitates novel tissue engineering strategies for skeletal muscle repair, which have traditionally involved cells and extracellular matrix-mimicking scaffolds and have thus far been unable to successfully restore physiologically relevant function. However, the incorporation of various nanomaterial additives with unique physicochemical properties into scaffolds has recently been explored as a means of fabricating constructs that are responsive to electrical, magnetic, and photothermal stimulation. Herein, several classes of nanomaterials that are used to mediate external stimulation to tissue engineered skeletal muscle are reviewed and the impact of these stimuli-responsive biomaterials on cell growth and differentiation and in vivo muscle repair is discussed. The degradation kinetics and biocompatibilities of these nanomaterial additives are also briefly examined and their potential for incorporation into clinically translatable skeletal muscle tissue engineering strategies is considered. Overall, these nanomaterial additives have proven efficacious and incorporation in tissue engineering scaffolds has resulted in enhanced functional skeletal muscle regeneration. 1. Introduction: Necessity for Stimuli-Responsive Constructs for Skeletal Muscle Tissue Engineering Volumetric muscle loss (VML) occurs when more than 20% of a muscle is lost, the point at which endogenous mechanisms for skeletal muscle self-repair are overcome. [1] VML frequently

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“…Given that the in vivo peripheral nervous system has a high degree of parallel alignment along a nerve fiber, we do not expect MN to have perpendicular contact guidance. Exploring the behavior of MN on synthetic substrates is an initial step toward the pursuit of better peripheral nerve grafts [26], artificial neuromuscular junctions [27], and electrode interfaces for future robotic prosthetics [28].…”

Section: Introductionmentioning

confidence: 99%

Growth of primary motor neurons on horizontally aligned carbon nanotube thin films and striped patterns

et al. 2014

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Alignment of muscle precursor cells on the vertical edges of thick carbon nanotube films

Cited by 6 publications

References 34 publications

Vertically Aligned Carbon Nanotubes as a Unique Material for Biomedical Applications

Vertically Aligned Carbon Nanotubes as a Unique Material for Biomedical Applications

Nanomaterial Additives for Fabrication of Stimuli‐Responsive Skeletal Muscle Tissue Engineering Constructs

Growth of primary motor neurons on horizontally aligned carbon nanotube thin films and striped patterns

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