Alfentanil does not increase resistance of the respiratory system in ASA I patients ventilated mechanically during general anesthesia

The influence of propofol, remifentanil and lidocaine on the tone of human bronchial smooth muscle

“…These data confirm the findings reported by Conti and colleagues, concerning the increasing of cholinergic stimulus mediated by opioids administration [46]. Our model does not permit to exclude an interference of remifentanil on the autonomic nervous system centres, which in turn may directly or indirectly enhance the bronchial tone, as previously speculated in human and confirmed in animal studies [46,48].…”

“…However, our results suggest an increasing in cholinergic tone peripherally at the level of bronchial parasympathetic ganglia. On the other hand, we can rule out the suggested influence of histamine in the bronchial hyperresponsiveness induced by remifentanil [45,46], since the baseline tone of human isolated bronchi was not modified by the treatment with the opioid.…”

Volatile rapid sequence induction in morbidly obese patients

“…13,26 Additionally, alfentanil has no respiratory adverse effects. 27 We utilised remifentanil as a perioperative drug after RSI to optimise the moment of extubation and a postoperative period. Suxamethonium was chosen because it is well documented in morbid obesity.…”

Guideline-oriented perioperative management of patients with bronchial asthma and chronic obstructive pulmonary disease

“…Remifentanil is ideal because no drug accumulation occurs [145]. All opioids have some histamine-releasing effects [10], but fentanyl and analogous agents can be safely used in patients with obstructive ventilatory impairment [146,147]. The use of opioids during intubation can prevent increased airway resistance.…”