2021
DOI: 10.1186/s12935-021-02210-5
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Abstract: Background ALDOA is a glycolytic enzyme found mainly in developing embryos, adult muscle and various malignant tumours, including pancreatic tumours. Our previous study revealed that ALDOA, an oncogene, can promote the proliferation and metastasis of pancreatic tumours. Furthermore, ALDOA could predict poor prognosis in patients with pancreatic tumours. Methods IHC analysis of PDAC tissues was conducted. Western blotting, PCR, cellular IF experimen… Show more

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Cited by 5 publications
(2 citation statements)
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“…Therefore, based on this phenotype, there 6). Besides, it is also possible that ATM might directly act on Mad2 or regulate some involved kinases through the non-Mad1 pathway to maintain the non-phosphorylation of Mad2 (Kastan and Lim, 2000;Chen et al, 2021;Jiang et al, 2022). Mad2 also plays a critical role in the cellular response to DNA damage (Dotiwala et al, 2010).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Therefore, based on this phenotype, there 6). Besides, it is also possible that ATM might directly act on Mad2 or regulate some involved kinases through the non-Mad1 pathway to maintain the non-phosphorylation of Mad2 (Kastan and Lim, 2000;Chen et al, 2021;Jiang et al, 2022). Mad2 also plays a critical role in the cellular response to DNA damage (Dotiwala et al, 2010).…”
Section: Discussionmentioning
confidence: 99%
“…When ATM is proficient in cells, ATM may inhibit Mad2 phosphorylation by urging the amount of S214p in Mad1 ( Figure 6 ). Besides, it is also possible that ATM might directly act on Mad2 or regulate some involved kinases through the non-Mad1 pathway to maintain the non-phosphorylation of Mad2 ( Kastan and Lim, 2000 ; Chen et al, 2021 ; Jiang et al, 2022 ).…”
Section: Discussionmentioning
confidence: 99%