2019
DOI: 10.18632/aging.102012
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Abstract: Acute lung injury (ALI) is a major cause of morbidity and mortality worldwide, especially in aged populations. Mitochondrial damage is one of the key features of ALI. Hyperoxia-induced lung injury model in mice has been widely used for ALI study because it features many ALI phenotypes including, but not limited to, mitochondrial and vascular endothelial cell damage. Recently, accumulating evidence has shown that mitochondrial aldehyde dehydrogenase 2 (ALDH2) has a protective effect against oxidative stress med… Show more

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Cited by 13 publications
(17 citation statements)
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“…The use of Alda-1 balances the kinetic properties of mitochondrial Aldh2 (Belmont-Diaz et al, 2016) and enhances mitochondrial membrane potential and inhibits mitochondrial ROS production (Solito et al, 2013;Chiu et al, 2015). Alda-1 pretreatment enhanced the mitochondrial membrane potential in endothelial cells of lung, brain, umbilical vein cells and inhibited ROS production in neuronal cells (Solito et al, 2013;Chiu et al, 2015;Patil et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
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“…The use of Alda-1 balances the kinetic properties of mitochondrial Aldh2 (Belmont-Diaz et al, 2016) and enhances mitochondrial membrane potential and inhibits mitochondrial ROS production (Solito et al, 2013;Chiu et al, 2015). Alda-1 pretreatment enhanced the mitochondrial membrane potential in endothelial cells of lung, brain, umbilical vein cells and inhibited ROS production in neuronal cells (Solito et al, 2013;Chiu et al, 2015;Patil et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…The p-mTOR and phosphor p70S6 kinase (Thr 389) levels are increased in hyperoxia vs. normoxia because cells have the adaptive response to survive the apoptosis execution pathway as represented by cytochrome c release. The cell that survived during hyperoxia could be specific progenitor type cells or cells which are dedifferentiated (Kotton and Morrisey, 2014;Fukumoto et al, 2019). Certain cell types in the lung like club cells are resistant to apoptosis and resides in bronchioles, near to alveoli and basal lung cells and plays a crucial role in regeneration, repair and homeostasis of epithelial cells when damaged (Rock et al, 2010;Volckaert and De Langhe, 2014;Fukumoto et al, 2019).Cell types such as type 1 and type 2 alveolar epithelial cells undergo apoptosis during hyperoxia conditions (Fukumoto et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
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“…Similarly, our current study found that DHY reduced the level of MDA and GSH/GSSG and alleviated DHE and DCFH-DA fluorescence intensity, but it enhanced T-AOC activity. Accumulating evidence has elucidated mitochondrial oxidative stress is closely associated with endothelial dysfunction [ 32 , 51 , 52 ]. Our results showed decreased SOD2 activity and expression, weak MitoSOX fluorescence intensity, as well as reduced mtDNA copy number, in the thoracic aorta of STZ-induced diabetic mice, which were restored by DHY.…”
Section: Discussionmentioning
confidence: 99%