Alcohol use disorder and circulating cytokines: A systematic review and meta-analysis

Adams, Claire; Conigrave, James H.; Lewohl, Joanne Marie; Haber, Paul; Morley, Kirsten C.

doi:10.1016/j.bbi.2020.08.002

Cited by 58 publications

(63 citation statements)

References 46 publications

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“…AUD is a condition associated with neuroadaptations, with morphological and immune alterations in neurons and glial cells that constitute the reward circuitry [ 101 , 102 , 103 ]. Changes in the inflammatory profile caused by alcohol have been described, and immune cells and cytokines are now regarded as biomarkers of alcohol use [ 10 , 104 ]. In the present study, we examined the IL-6 and CX3CL1 levels in the striatum, a key reward brain area, to distinguish between the acute and the long-term neuroinflammatory effects of BD and HFD during adolescence.…”

Section: Discussionmentioning

confidence: 99%

Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice

González-Portilla

Montagud‐Romero

Navarrete

et al. 2021

IJMS

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Alcohol binge drinking (BD) and poor nutritional habits are two frequent behaviors among many adolescents that alter gut microbiota in a pro-inflammatory direction. Dysbiotic changes in the gut microbiome are observed after alcohol and high-fat diet (HFD) consumption, even before obesity onset. In this study, we investigate the neuroinflammatory response of adolescent BD when combined with a continuous or intermittent HFD and its effects on adult ethanol consumption by using a self-administration (SA) paradigm in mice. The inflammatory biomarkers IL-6 and CX3CL1 were measured in the striatum 24 h after BD, 3 weeks later and after the ethanol (EtOH) SA. Adolescent BD increased alcohol consumption in the oral SA and caused a greater motivation to seek the substance. Likewise, mice with intermittent access to HFD exhibited higher EtOH consumption, while the opposite effect was found in mice with continuous HFD access. Biochemical analyses showed that after BD and three weeks later, striatal levels of IL-6 and CX3CL1 were increased. In addition, in saline-treated mice, CX3CL1 was increased after continuous access to HFD. After oral SA procedure, striatal IL-6 was increased only in animals exposed to BD and HFD. In addition, striatal CX3CL1 levels were increased in all BD- and HFD-exposed groups. Overall, our findings show that adolescent BD and intermittent HFD increase adult alcohol intake and point to neuroinflammation as an important mechanism modulating this interaction.

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Section: Discussionmentioning

confidence: 99%

Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice

González-Portilla

Montagud‐Romero

Navarrete

et al. 2021

IJMS

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“…Together with the effect of alcohol consumption on Toll-like receptors [ 90 , 91 , 92 ], one of the most reported data are the upregulation of several cytokines after alcohol administration [ 93 ]. In fact, a recent meta-analysis [ 94 ] studied the differences in cytokine patterns presented by subjects with AUD and concluded that they show a higher concentration of cytokines than control patients. Furthermore, these authors found clear differences depending on the different stages of AUD illness: active drinking, withdrawal and various periods of abstinence.…”

Section: Effects Of Alcohol On Immune System: Putting All the Pieces Togethermentioning

confidence: 99%

The Immune System through the Lens of Alcohol Intake and Gut Microbiota

Calleja‐Conde

Echeverry‐Alzate

Bühler

et al. 2021

IJMS

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The human gut is the largest organ with immune function in our body, responsible for regulating the homeostasis of the intestinal barrier. A diverse, complex and dynamic population of microorganisms, called microbiota, which exert a significant impact on the host during homeostasis and disease, supports this role. In fact, intestinal bacteria maintain immune and metabolic homeostasis, protecting our organism against pathogens. The development of numerous inflammatory disorders and infections has been linked to altered gut bacterial composition or dysbiosis. Multiple factors contribute to the establishment of the human gut microbiota. For instance, diet is considered as one of the many drivers in shaping the gut microbiota across the lifetime. By contrast, alcohol is one of the many factors that disrupt the proper functioning of the gut, leading to a disruption of the intestinal barrier integrity that increases the permeability of the mucosa, with the final result of a disrupted mucosal immunity. This damage to the permeability of the intestinal membrane allows bacteria and their components to enter the blood tissue, reaching other organs such as the liver or the brain. Although chronic heavy drinking has harmful effects on the immune system cells at the systemic level, this review focuses on the effect produced on gut, brain and liver, because of their significance in the link between alcohol consumption, gut microbiota and the immune system.

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“…interleukin 7 , interleukin 8 , and tumor necrosis factor [TNFα]), among individuals with alcohol use disorder (AUD) compared with control individuals (Adams et al, 2020). Importantly, chronic alcohol consumption is also thought to be related to inflammation within the brain, known as neuroinflammation (Crews et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, we proposed a broad conceptual model, in which we predicted that drinks per drinking day (DPDD) would be associated with plasma IL-6, as well as GM and WM, and that IL-6 would be correlated with GM and WM. IL-6 was selected as the candidate cytokine of interest given the consistent links between IL-6 and alcohol consumption in the preclinical (Gano et al, 2016) and human literature (Adams et al, 2020), as well as between IL-6, GM (Marsland et al, 2008), and WM (Bettcher et al, 2014). We further hypothesized that GM and WM would be associated with plasma NfL.…”

Section: Introductionmentioning

confidence: 99%

Exploring relationships between alcohol consumption, inflammation, and brain structure in a heavy drinking sample

Karoly

Skrzynski

Moe

et al. 2021

Alcoholism Clin & Exp Res

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Background: Chronic alcohol consumption is associated with structural brain changes and increased inflammatory signaling throughout the brain and body. Increased inflammation in the brain has been associated with structural damage. Recent studies have also shown that neurofilament light polypeptide (NfL) is released into the systemic circulation following neuronal damage. Although NfL has thus been proposed as a biomarker for neurodegenerative diseases, its connection to alcohol use disorder has not been explored. For this secondary data analysis, we proposed a conceptual model linking alcohol consumption, the pro-inflammatory cytokine IL-6, brain structure, and NfL in heavy drinking participants. Methods:Of the 182 individuals enrolled in this study, 81 participants had usable data on gray matter (GM) thickness and 80 had usable data on white matter (WM) diffusivity. A subset of participants had NfL (n = 78) and IL-6 (n = 117) data. An estimate of GM thickness was extracted from middle frontal brain regions using FreeSurfer. Estimated mean WM diffusivity values were extracted from Tract Based Spatial Statistics. NfL and IL-6 were measured in blood. Regression models were used to test individual linkages in the conceptual model. Based on significant regression results, we created a simplified conceptual model, which we tested using path analysis. Results:In regressions, negative relationships emerged between GM and both drinks per drinking day (DPDD) (p = 0.018) and NfL (p = 0.004). A positive relationship emerged between WM diffusivity and DPDD (p = 0.033). IL-6 was not significantly associated with alcohol use, GM or WM. The final path model demonstrated adequate fit to the data and showed significant, negative associations between DPDD and middle frontal gyrus (MFG) thickness, and between MFG thickness and NfL, but the association between DPDD and NfL was not significant.Conclusions: This is the first study to show that heavy drinking is associated with lower GM thickness and higher WM diffusivity and that lower GM thickness is associated with higher circulating NfL. The analyses also show that the effects of drinking do not involve the pro-inflammatory cytokine IL-6.

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Alcohol use disorder and circulating cytokines: A systematic review and meta-analysis

Cited by 58 publications

References 46 publications

Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice

Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice

The Immune System through the Lens of Alcohol Intake and Gut Microbiota

Exploring relationships between alcohol consumption, inflammation, and brain structure in a heavy drinking sample

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