Alcohol, Seizures, and Epilepsy

Hauser, W. Allen; Ng, Sally; Brust, John C.M.

doi:10.1111/j.1528-1157.1988.tb05800.x

Cited by 72 publications

(40 citation statements)

References 61 publications

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“…Die höchste Inzidenz Alkoholentzugs-bedingter Anfälle liegt im höheren Lebensalter [46]. Ältere Patienten sind eher gefährdet, Anfälle durch Medikamentenintoxikation oder durch begleitende Erkrankungen zu bekommen.…”

Section: äTiologieunclassified

Epilepsie im Alter

Werhahn

2004

Z Epileptol

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Section: äTiologieunclassified

Epilepsie im Alter

Werhahn

2004

Z Epileptol

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“…Individual brains were homogenized for 10 seconds in 2 vol of methanol with an ultrasonic cell disruptor (Sonifer, Branson, Danbury, CT). Homogenates were centrifuged at 10,000g for 10 minutes at 4°C, and supernatants were added to an equal volume of the mobile-phase carrier used for the subsegment assay (10% methanol containing 0.15 M NaCl, 0.15 M NH 4 Cl, and 0.5 g/L sodium EDTA; EICOM, Kyoto, Japan). The mixture was stored at Ϫ80°C for 1 to 3 days until assay.…”

Section: No Metabolites In the Brain And Serummentioning

confidence: 99%

The Effect of Alcohol on Convulsions and Nitric Oxide Levels in Seizure-Susceptible EL Mice

Nagatomo

Uchida

Akasaki

et al. 2000

Epilepsy & Behavior

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“…As we known, alcohol and epilepsy are complexly interrelated and have been linked since hippocrates 6 . Experimental and clinical studies have been shown that seizures may occur during alcohol intoxication 7,8 and that patients with epilepsy who drink moderate or heavy amounts of alcohol could increase the risk of seizures 6 .…”

mentioning

confidence: 99%

“…Experimental and clinical studies have been shown that seizures may occur during alcohol intoxication 7,8 and that patients with epilepsy who drink moderate or heavy amounts of alcohol could increase the risk of seizures 6 . Moreover, alcohol is a risk factor for ischemic cerebral infarction 9 and increases the chances of head trauma 10 , both of which are known factors in inducing epilepsy.…”

mentioning

confidence: 99%

Alcohol consumption and sudden unexpected death in epilepsy: experimental approach

ScorzaI

Cysneiros

Arida

et al. 2009

Arq. Neuro-Psiquiatr.

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-Using the pilocarpine model of epilepsy, we investigated the effects of alcohol consumption on the frequency of seizures in animals with epilepsy as well the underlying a possible association between alcohol intake and sudden unexpected death in epilepsy (SUDEP) occurrence. Rats were divided randomly into two groups: (A) rats with epilepsy and (B) rats with epilepsy that received a daily dose of ethanol solution (350 mg kg -1 , i.p.) for 30 days. The basal frequency of seizures observed in the A and B groups during the first 30 days were 3.4±1.5 and 3.2±1.9 seizures per week per animal, respectively. In B group, it was observed a significant seizure increase (11.6±5.3) during the first 2 weeks of alcohol administration and quite interesting, one rat died suddenly after a generalized tonic-clonic seizure during this period. We concluded in our experimental study that exist a possible association between alcohol abuse and SUDEP occurrence.KEy WoRDS: epilepsy, alcohol, heart, seizure, SUDEP. Consumo de álcool e morte súbita em epilepsia: uma abordagem experimentalResumo -Utilizando o modelo de epilepsia induzido pela pilocarpina, investigamos os efeitos do consumo de álcool sobre a frequência de crises epilépticas em animais com epilepsia, como também uma possível associação entre a ingestão de álcool e ocorrência de morte súbita e inesperada nas epilepsias (SUDEP). os animais foram randomicamente divididos em dois grupos: (A) ratos com epilepsia e (B) ratos com epilepsia que receberam uma dose diária de etanol (350 mg kg -1 , i.p.) por 30 dias consecutivos. A frequência basal de crises epilépticas observadas nos grupos A e B durante os primeiros 30 dias foram de 3,4±1,5 e 3,2±1,9 crises por semana/animal, respectivamente. No grupo B, ocorreu aumento significativo na frequência de crises (11,6±5,3) durante as duas primeiras semanas de administração do álcool e de forma interessante, um animal morreu subitamente após uma crise generalizada tônico-clonica durante esse período. Concluímos em nossa abordagem experimental que existe uma possível associação entre o consumo de álcool e a ocorrência de SUDEP. PAlAvRAS-ChAvE: epilepsia, álcool, coração, crise epiléptica, SUDEP. Epilepsy is one of the most prevalent neurological conditions 1 and people with epilepsy are more likely to die prematurely than those without epilepsy, and the most common epilepsy-related category of death is sudden unexpected death in epilepsy (SUDEP) 1,2 . The cause of SUDEP is still unknown; however, the most commonly suggested mechanisms are cardiac abnormalities during and between seizures 2,3 . Additionally, a number of associated factors for SUDEP have been reported but the results are not wholly consistent between studies. These include refractoriness of the epilepsy, presence of generalized tonic-clonic seizures, polytherapy with antiepileptic

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Alcohol, Seizures, and Epilepsy

Cited by 72 publications

References 61 publications

Epilepsie im Alter

Epilepsie im Alter

The Effect of Alcohol on Convulsions and Nitric Oxide Levels in Seizure-Susceptible EL Mice

Alcohol consumption and sudden unexpected death in epilepsy: experimental approach

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