Alcohol-induced testicular oxidative stress and cholesterol homeostasis in rats – The therapeutic potential of virgin coconut oil

Dosumu, Olufunke O.; Akinola, Oluwole Busayo; Akang, E. E. U.

doi:10.1016/j.mefs.2011.12.005

Cited by 28 publications

(33 citation statements)

References 44 publications

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“…Virgin coconut oil (VCO) is a natural oil which has in recent times gained tremendous popularity globally owing to its wide range of health benefits. It has been reported to significantly improve semen quality as well as testosterone levels that are adversely affected by alcohol (Dosumu et al ., ). Our previous study also demonstrated the mitigating potential of VCO on HAART‐induced testicular ravages (Ogedengbe et al ., ).…”

Section: Introductionmentioning

confidence: 97%

“…They are less liable to cause toxic effects and are locally accessible and inexpensive (Jaarin et al ., ). Certain herbal remedies also show some degree of efficacy against HIV infections (Mills et al ., ; Zou et al ., ), as well as ameliorating testicular damage caused either by alcohol (Kurus et al ., ; Dosumu et al ., ) or HAART (Ogedengbe et al ., ; Jegede et al ., ).…”

Section: Introductionmentioning

confidence: 99%

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Virgin coconut oil extract mitigates testicular‐induced toxicity of alcohol use in antiretroviral therapy

et al. 2018

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The consumption of alcohol by people living with HIV/AIDS is associated with a graver prognosis. Long-term use of antiretrovirals may have certain health challenges that may be aggravated by concomitant alcohol use. This study investigated virgin coconut oil (VCO) as an adjuvant to the deleterious effects of highly active antiretroviral therapy (HAART) and alcohol on the cyto-architecture and functioning of the testis. Forty adult male Sprague-Dawley rats, weighing 165~176 g, were divided into eight groups and treated according to protocol. Testicular histology, stereological parameters, seminal fluid, testosterone, luteinizing hormone, follicle-stimulating hormone, the antioxidants marker malondialdehyde (MDA), and antioxidant glutathione (GSH) were examined. The use of ethanol alone and ethanol + HAART showed extensive degeneration in the seminiferous epithelium, decreased semen quality, disorganized basement membrane and widened, hypocellular interstitium. GSH was significantly decreased in the ethanol alone treated group with no significant effect on testosterone, LH, and MDA levels. Adjuvant treatment with VCO at low dose (2.5 mL/kg/bw) improved sperm motility with a partial restoration of the histopathological alterations. High doses of VCO (5.0 mL/kg/bw) showed greater improvement with respect to sperm counts, increased FSH hormonal and GSH antioxidant levels, and a well-preserved testicular cyto-architecture.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Virgin coconut oil extract mitigates testicular‐induced toxicity of alcohol use in antiretroviral therapy

et al. 2018

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“…It has captured a lot of interest due to its ability to mitigate oxidative stress-related processes via inhibition of lipid peroxidation (22). Reports of its improvement of semen quality (sperm counts and motility) as well as boosting serum testosterone levels (23) have been acknowledged. Though VCO has many therapeutic values, there are no scientific reports on its ability to mitigate testicular injuries associated with any HAART either in human and/or experimental animal model.…”

Section: Introductionmentioning

confidence: 99%

Coconut Oil Extract Mitigates Testicular Injury Following Adjuvant Treatment with Antiretroviral Drugs

et al. 2016

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Increased access to highly active antiretroviral therapy (HAART) has made the management of drug toxicities an increasingly crucial component of HIV. This study investigated the effects of adjuvant use of coconut oil and HAART on testicular morphology and seminal parameters in Sprague- Dawley rats. Twelve adult male Sprague-Dawley rats, weighing 153~169 g were distributed into four groups (A–D) and treated as follows: A served as control (distilled water); B (HAART cocktail- Zidovudine, Lamivudine and Nevirapine); C (HAART + Virgin coconut oil 10 mL/kg) and D (Virgin coconut oil 10 mL/kg). After 56 days of treatment, animals were killed and laparotomy to exercise the epididymis for seminal fluid analyses done whilst testicular tissues were processed for histomorphometric studies. Result showed a significant decline in sperm motility (P < 0.05) and count (P < 0.0001) in HAART-treated animals while there was insignificant changes in other parameters in groups C and D except count that was reduced (P < 0.0001) when compared with controls. Histomorphological studies showed HAART caused disorders in seminiferous tubular architecture with significant (P < 0.01) decline in epithelial height closely mirrored by extensive reticulin framework and positive PAS cells. Adjuvant Virgin coconut oil + HAART resulted in significant decrease in seminiferous tubular diameter (P < 0.05), but other morphometric and histological parameters were similar to control or Virgin coconut oil alone (which showed normal histoarchitecture levels). While derangements in testicular and seminal fluid parameters occurred following HAART, adjuvant treatment with Virgin coconut oil restored the distortions emanating thereof.

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“…It was shown earlier that chronic consumption of alcohol increases oxidative stress [28]. Increased and prolonged oxidative stress causes testicular damage which impedes spermatogenesis resulting in decreased sperm count [29], [30]. Young men in the western world have a high alcohol intake, which of public health concern and could be a contributing factor to the low sperm count reported among young men [31].…”

Section: Discussionmentioning

confidence: 99%

Abnormalities in Semen Parameters of Men Due to Consumption of Alcohol

2016

IJSR

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Abstract:To investigate the effects of alcohol consumption on semen parameters, semen samples were collected from eighty (80) alcohol consumption men. This sample was from a cross section of population of Anantapuramu district, Andhra Pradesh, India. They were divided into two age groups namely 25-35 years and 35-45 years. In both age groups persons were selected basing as how many units of alcohol they consumed in a day. Different semen parameters like volume, liquefaction, alkalinity, sperm count, motility and morphology were analysed. Incidences of Hypospermia in 43, Teratozoospermia in 21, Oligozoospermia in 59, Oligoasthenozoospermia in 22 and Oligoasthenoteratozoopermia in 6 persons were observed. Abnormalities were seen in both age groups and was more pronounced in persons who consumed alcohol either moderately or heavily.

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Alcohol-induced testicular oxidative stress and cholesterol homeostasis in rats – The therapeutic potential of virgin coconut oil

Cited by 28 publications

References 44 publications

Virgin coconut oil extract mitigates testicular‐induced toxicity of alcohol use in antiretroviral therapy

Virgin coconut oil extract mitigates testicular‐induced toxicity of alcohol use in antiretroviral therapy

Coconut Oil Extract Mitigates Testicular Injury Following Adjuvant Treatment with Antiretroviral Drugs

Abnormalities in Semen Parameters of Men Due to Consumption of Alcohol

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