Alcohol drinking patterns and the risk of fatty liver in Japanese men

Abstract

Our observations suggest that alcohol consumption plays a protective role against FL in men, and consistent alcohol consumption may contribute to this favorable effect.

Impact of cigarette smoking on onset of nonalcoholic fatty liver disease over a 10-year period

“…In a cross-sectional study in Japanese men, low alcohol consumption (40-140 g/week) significantly reduced the incidence of fatty liver (AOR = 0.824 [95% CI 0.683-0.994]) [20]. We have also found that alcohol intake may inhibit the development of fatty liver through an association of alcohol drinking pattern with obesity [48]. In the current study, intake of a small amount of alcohol had an inhibitory effect on NAFLD development in multivariate analysis that included the number of metabolic syndrome risk factors as a variable (Table 5).…”

Modest alcohol consumption decreases the risk of non-alcoholic fatty liver disease: a meta-analysis of 43 175 individuals

“…[2][3][4][5][6][7][8][9] In conclusion, quantitative evidence showed that MAC is associated with a significant protective effect of about 31% on the risk of having NAFLD. Even more remarkable, MAC was associated with an average protective effect of about 50% on the risk of developing an advanced disease stage.…”

Alcohol consumption and risk of fatty liver disease: a meta-analysis

“…Then, 19 English and four Chinese studies remained for complete evaluation, four Chinese studies were excluded due to design weakness or low quality data, two English studies were excluded due to a lack of data for calculation, and one English study was discarded due to duplication. In the end, 16 observational articles with a total of 76,608 participants including 39,198 nondrinkers, 31,942 light to moderate drinkers (LM drinkers), and 5,468 heavy drinkers met our inclusion criteria (Dunn, Xu & Schwimmer, 2008; Cotrim et al, 2009; Gunji et al, 2009; Yamada et al, 2010; Hiramine et al, 2011; Dunn et al, 2012; Hamaguchi et al, 2012; Wong et al, 2012; Moriya et al, 2013; Sookoian, Castaño & Pirola, 2014; Hashimoto et al, 2015; Kächele et al, 2015; Lau et al, 2015; Moriya et al, 2015; Nishioji et al, 2015; Sogabe et al, 2015). There were 13 cross-sectional studies (Dunn, Xu & Schwimmer, 2008; Cotrim et al, 2009; Gunji et al, 2009; Hiramine et al, 2011; Dunn et al, 2012; Hamaguchi et al, 2012; Wong et al, 2012; Moriya et al, 2013; Sookoian, Castaño & Pirola, 2014; Kächele et al, 2015; Lau et al, 2015; Nishioji et al, 2015; Sogabe et al, 2015), two cross-sectional following longitudinal studies (Yamada et al, 2010; Moriya et al, 2015) and one cohort study (Hashimoto et al, 2015).…”

“…In the end, 16 observational articles with a total of 76,608 participants including 39,198 nondrinkers, 31,942 light to moderate drinkers (LM drinkers), and 5,468 heavy drinkers met our inclusion criteria (Dunn, Xu & Schwimmer, 2008; Cotrim et al, 2009; Gunji et al, 2009; Yamada et al, 2010; Hiramine et al, 2011; Dunn et al, 2012; Hamaguchi et al, 2012; Wong et al, 2012; Moriya et al, 2013; Sookoian, Castaño & Pirola, 2014; Hashimoto et al, 2015; Kächele et al, 2015; Lau et al, 2015; Moriya et al, 2015; Nishioji et al, 2015; Sogabe et al, 2015). There were 13 cross-sectional studies (Dunn, Xu & Schwimmer, 2008; Cotrim et al, 2009; Gunji et al, 2009; Hiramine et al, 2011; Dunn et al, 2012; Hamaguchi et al, 2012; Wong et al, 2012; Moriya et al, 2013; Sookoian, Castaño & Pirola, 2014; Kächele et al, 2015; Lau et al, 2015; Nishioji et al, 2015; Sogabe et al, 2015), two cross-sectional following longitudinal studies (Yamada et al, 2010; Moriya et al, 2015) and one cohort study (Hashimoto et al, 2015). Of the studies, 10 were conducted in Asia (nine in Japan (Gunji et al, 2009; Yamada et al, 2010; Hiramine et al, 2011; Hamaguchi et al, 2012; Moriya et al, 2013; Hashimoto et al, 2015; Moriya et al, 2015; Nishioji et al, 2015; Sogabe et al, 2015) and one in Hong Kong (Wong et al, 2012)) and six in other countries (two in the US (Dunn, Xu & Schwimmer, 2008; Dunn et al, 2012), 1 in Brazil (Cotrim et al, 2009), 1 in Argentina (Sookoian, Castaño & Pirola, 2014) and 2 in Germany (Kächele et al, 2015; Lau et al, 2015)).…”