Alcohol Drinking in Never Users of Tobacco, Cigarette Smoking in Never Drinkers, and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

Hashibe, Mia; Brennan, Paul; Benhamou, Simone; Castellsagué, Xavier; Chen, Chu; Curado, María Paula; Maso, Luigino Dal; Daudt, Alexander W.; Fabiánovà, Eleonóra; Wünsch-Filho, Victor; Franceschi, Silvia; Hayes, Richard B.; Herrero, Rolando; Koifman, Sérgio; Vecchia, Carlo La; Lazarus, Philip; Levi, Fabio; Mateș, Dana; Matos, Elena; Menezes, Ana; Muscat, Joshua E.; Eluf-Neto, José; Olshan, Andrew F.; Rudnai, Péter; Schwartz, Stephen M.; Smith, Elaine; Sturgis, Erich M.; Szeszenia-Dabrowska, Neonilia; Talamini, Renato; Wei, Qingyi; Winn, Deborah M.; Заридзе, Давид; Zatoński, Witold; Zhang, Zuo‐Feng; Berthiller, Julien; Boffetta, Paolo

doi:10.1093/jnci/djk179

Cited by 868 publications

(746 citation statements)

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“…13 The results in the present study for the effect of tobacco smoking and alcohol consumption confi rm what is long known, that these two exposures are the main risks for oral cavity and oropharynx cancers. 10 No association was seen between complete dental prosthesis and oral cancer, corroborating other studies. 8,11,12 On the other hand, high association of frequent gum bleeding during toothbrushing and oral cancer was found.…”

Section: Discussionsupporting

confidence: 87%

“…Linear trend was estimated for alcohol consumption and smoking by fi tting the categorical variable into the logistic regression model as a continuous variable. 10 The study was approved by the Research Ethical Committees of all participating medical sites and Universidade de São Paulo School of Public Health, as well as by the National Human Research Ethics Committee of the Brazilian Ministry of Health. Cases and controls were informed of the objectives and uses of the research project both in person and through a consent form, which was signed by them.…”

Section: Methodsmentioning

confidence: 99%

“…19 The city of São Paulo has the highest incidence of oral cancer in the Brazil, 25.3 cases per 100,000 males and 4.9 per 100,000 females. 20 Smoking and alcohol consumption are widely recognized as risk factors for oral cancer, 10,a,b,c but also nutrition, 6 occupation 1 and metabolic gene polymorphisms 9 seem to have specifi c roles for the development of oral cancer. Previous epidemiological studies have provided evidence of the effect of oral health status and oral hygiene practices on the development of oral cancer.…”

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confidence: 99%

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Oral health, hygiene practices and oral cancer

et al. 2008

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Oral health, hygiene practices and oral cancerSaúde bucal, práticas de higiene bucal e ocorrência de câncer da cavidade oral ABSTRACT OBJECTIVE: To assess the association between oral health and hygiene practices and oral cancer. METHODS:Hospital-based case-control study in the metropolitan area of São Paulo, southeastern Brazil, from 1998 to 2002. A total 309 patients with squamous cell carcinoma of the mouth and the pharynx and 468 controls matched by sex and age were included in the study. Cases were recruited in seven reference hospitals and controls were selected in fi ve out of the seven participating hospitals. Detailed information on smoking, alcohol consumption, schooling, oral health status and hygiene practices were obtained through interviews. Odds ratios (OR) and 95% confi dence intervals (95% CI), adjusted by sex, age, schooling, smoking, alcohol consumption as well as the variables oral health status and hygiene practices were estimated using unconditional logistic regression analyses. RESULTS:The use of complete dental prosthesis was not associated with oral cancer but regular gum bleeding showed a strong association (OR 3.1; 95% CI 1.2-7.9). Those who never attended a dental visit were more likely to have oral cancer (OR 2.5; 95% CI 1.3-4.8). Daily mouthwash use showed a stronger association to pharynx (OR 4.7; 95% CI 1.8-12.5) than mouth cancer (OR 3.2; 95% CI 1.6-6.3). CONCLUSIONS:Gum bleeding, no dental care, and daily mouthwash use were factors associated with oral cancer regardless of tobacco and alcohol consumption. 472Oral health and hygiene practices on oral cancer Marques LA et al Oral cancer accounts for 7% of all new cancer cases worldwide, around 270,000 cases annually. In developing countries, it is the fi fth most common cancer in men and the seventh in women. 15 In South America, Brazil has the highest rates of oral cancer in men. 19 The city of São Paulo has the highest incidence of oral cancer in the Brazil, 25.3 cases per 100,000 males and 4.9 per 100,000 females. 20 Smoking and alcohol consumption are widely recognized as risk factors for oral cancer, 10,a,b,c but also nutrition, 6 occupation 1 and metabolic gene polymorphisms 9 seem to have specifi c roles for the development of oral cancer. Previous epidemiological studies have provided evidence of the effect of oral health status and oral hygiene practices on the development of oral cancer. Poor oral hygiene seems to cause additional cancer RESUMO OBJETIVO: Avaliar a associação entre saúde e higiene bucal na ocorrência de câncer oral. MÉTODOS:Estudo caso-controle de base hospitalar, realizado entre 1998 e 2002 na área metropolitana de São Paulo, SP. Foram incluídos 309 pacientes com carcinoma epidermóide de boca e orofaringe e 468 controles, pareados com os casos por sexo e idade. Os casos foram levantados em sete hospitais que concentram a assistência médica a pacientes com a doença e os controles rastreados em cinco hospitais gerais dentre os sete. Informações pormenorizadas sobre tabagismo, consumo de álcool, escolarida...

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Section: Discussionsupporting

confidence: 87%

Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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Oral health, hygiene practices and oral cancer

et al. 2008

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“…Alcohol consumption has been linked to periodontitis 19 and tooth wear 20 and both smoking and alcohol are closely linked to the incidence of oral cancer. 21 The incidence of oral cancer is also strongly related to social and economic deprivation, 22 particularly for men, and this widening inequalities gap makes it all the more important that all avenues to address possible risk factors are explored. All patient examinations in the CDS include smoking and alcohol cessation advice related to risks of oral disease and cancer.…”

Section: Discussionmentioning

confidence: 99%

Developing dental services for homeless people in East London

2012

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“…19 The reported pooled cancer risk estimate is 3.43 times higher in smokers compared with non-smokers (95% CI, 2.37 -4.94). 20 Yet in this study smoking did not figure prominently in patients' accounts of why they contracted the disease.…”

Section: Understanding and Awarenessmentioning

confidence: 96%

The experiences of young oral cancer patients in Scotland: symptom recognition and delays in seeking professional help

et al. 2010

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Objectives: To explore the early responses of young oral cancer patients in Scotland to the symptoms of their emerging condition, to understand the ways they seek help and to inquire into delay caused by not recognising symptoms associated with cancer. Setting: The survey was carried out in Maggie's Centres or in patients' own homes in Glasgow and Edinburgh among young patients diagnosed with oral cancer in the three years (2004-7) before the study. Methods: This study employed qualitative methods. Data were collected by interview using a semi-structured interview schedule. The interview transcripts were analysed using a thematic framework and with the aid of NVivo qualitative analysis software (Version 8). Results: Most of the cohort knew that smoking and alcohol could cause oral cancer. None thought it would happen to them. Descriptions of symptoms varied widely and several had used self-treatment provided from a pharmacy. There were various causes of 'patient delay' and self-treatment was not the only cause. Reinterpretation of symptoms without seeking professional help was not uncommon. Nobody suspected they had oral cancer until it was confirmed by their GP or GDP. All thought that something so small and painless couldn't be a serious problem. Conclusions: The study further confirms gaps in understanding and awareness of oral cancer. Most had heard of oral cancer but they didn't think their symptoms were indicative of cancer and they self managed the problem. The culture of not bothering the GP/GDP unless it was perceived as serious is a barrier to earlier access. Findings support that further public awareness of oral cancer and its symptoms is required to alert the public that if their symptoms persist beyond three weeks they need a professional opinion

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Alcohol Drinking in Never Users of Tobacco, Cigarette Smoking in Never Drinkers, and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

Abstract: Our results represent the most precise estimates available of the independent association of each of the two main risk factors of head and neck cancer, and they exemplify the strengths of large-scale consortia in cancer epidemiology.

Cited by 868 publications

References 30 publications

Oral health, hygiene practices and oral cancer

Oral health, hygiene practices and oral cancer

Developing dental services for homeless people in East London

The experiences of young oral cancer patients in Scotland: symptom recognition and delays in seeking professional help

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