Alcohol consumption and idiopathic dilated cardiomyopathy: A case control study

Reversible Dilated Cardiomyopathy: Into the Thaumaturgy of the Heart - Part 2

“…24,25 Excessive alcohol intake is currently recognized as a common cause of dilated cardiomyopathy (DCM), and DCM due to alcohol abuse is known as alcohol-related cardiomyopathy (ACM) (Table 1, Figure 1). 25,26 The evidence supporting excessive alcohol exposure as a cause of DCM includes several experimental studies, 25 epidemiological studies showing higher prevalence of excessive alcohol consumption in DCM patients than in the general population, 27 and echocardiographic studies in asymptomatic alcohol abusers. 28 Based on experimental studies the pathophysiology of ACM includes several processes with a crucial role of apoptosis 29 and excess oxidative stress.…”

“…The controversy emerges from the observation that studies evaluating the effect of alcohol abstinence included patients who reduced alcohol intake to low/moderate levels alongside with those who stopped consuming alcohol completely. [21][22][23][24][25][26][27][28][29][30][31][32][33][34] Furthermore, the only contemporary study found that prognosis and degree of LVEF recovery in ACM patients who decreased alcohol intake to moderate levels was comparably favorable to that of abstainers. 36 Ultimately, complete alcohol cessation appears desirable for ACM patients giving the fact that these patients have suffered an important addiction and may find it extremely difficult to maintain low-moderate intakes over time.…”

Alcoholic Cardiomyopathy: Basic Aspects of Epidemiology, Pathogenesis and Pharmacotherapy

“…Отчасти это было обусловлено тем, что до середины 2000-х годов эта причина смерти не кодировалась отдельно органами ЗАГС, ответственными за регистрацию и сертификацию смерти в России. По данным разных авторов распро-страненность заболевания колеблется в пределах от 3,8% до 40% всех кардиомиопатий [15][16][17][18]. Боль-шинство больных АКМП составляют мужчины, тогда как на долю женщин приходится лишь 14%, причем ле-тальность от данного заболевания также выше у муж-чин.…”

“…В среднем длительность употребления алко-голя по данным большинства авторов была 15 лет [16,17,[23][24][25][26].…”

Triggers of Ischemic Stroke

“…Cardioembolism caused by cardiac arrhythmias, 46 -49 possibly favored by cardiomyopathy in case of associated chronic alcohol intoxication is strongly suspected. 25,46,50 Other mechanisms include paradoxical emboli via patent foramen ovale during Valsalva maneuver (eg, vomiting), artery-to-artery emboli after dislodging of arterial thrombi secondary to a sudden increase in blood flow following alcohol intoxication, 25,50,51 traumatic arterial dissection, platelet activation, 52 and possible changes in hemostatic and fibrinolytic parameters, although such disturbances have been mainly reported in chronic alcohol intoxication. 50,53 Because some of these mechanisms are specific to IS, it may explain why no association between acute alcohol abuse and MI was found.…”