Alcohol and head and neck cancer

Kawakita, Daisuke; Matsuo, Keitaro

doi:10.1007/s10555-017-9690-0

Cited by 110 publications

(81 citation statements)

References 95 publications

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“…The negative pleiotropy could be partly attributable to two oral cavity/pharyngeal PRS variants (rs467095 and rs10462706; Supplementary Tables 8 and 9), both expression quantitative trait loci for TERT and CLPTM1L, which were inversely associated with lung cancer risk and in LD (r 2 =0.96 and 0.66, respectively) with variants in the lung cancer PRS. The oral cavity/pharyngeal cancer PRS was also associated with increasing alcohol intake, an established risk factor for such cancers (24). The relationship between alcohol intake and lung cancer remains controversial, with the possibility of an inverse or J-shaped relationship (25,26).…”

Section: Discussionmentioning

confidence: 99%

Cross-Cancer Evaluation of Polygenic Risk Scores for 17 Cancer Types in Two Large Cohorts

Graff

Cavazos

Thai

et al. 2020

Preprint

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Genetic factors that influence etiologic mechanisms shared across cancers could affect the risk of multiple cancer types. We investigated polygenic risk score (PRS)-specific pleiotropy across 17 cancers in two large population-based cohorts. The study population included European ancestry individuals from the Genetic Epidemiology Research on Adult Health and Aging cohort (16,012 cases, 50,552 controls) and the UK Biobank (48,969 cases, 359,802 controls). We selected known independent risk variants from published GWAS to construct a PRS for each cancer type. Within cohorts, each PRS was evaluated in multivariable logistic regression models with respect to the cancer for which it was developed and each other cancer type. Results were then meta-analyzed across cohorts. In the UK Biobank, each PRS was additionally evaluated relative to 20 cancer risk factors or biomarkers. All PRS replicated associations with their corresponding cancers (p<0.05). Eleven cross-cancer associations -ten positive and one inverse -were found after correction for multiple testing (p<0.05/17=0.0029). Two cancer pairs showed bidirectional associations; the melanoma PRS was positively associated with oral cavity/pharyngeal cancer and vice versa, whereas the lung cancer PRS was positively associated with oral cavity/pharyngeal cancer, and the oral cavity/pharyngeal cancer PRS was inversely associated with lung cancer. We identified 65 associations between a cancer PRS and non-cancer phenotype. In this study examining cross-cancer PRS associations in two cohorts unselected for phenotype, we validated known and uncovered novel patterns of pleiotropy. Our results have the potential to inform investigations of risk prediction, shared etiology, and precision cancer prevention strategies. 5 STATEMENT OF SIGNIFICANCEBy examining cross-cancer polygenic risk score associations, we validated known and uncovered novel patterns of pleiotropy. Our results may inform investigations of risk prediction, shared etiology, and precision prevention strategies.

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Section: Discussionmentioning

confidence: 99%

Cross-Cancer Evaluation of Polygenic Risk Scores for 17 Cancer Types in Two Large Cohorts

Graff

Cavazos

Thai

et al. 2020

Preprint

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“…An important confounder in the relationship between solid organ transplant and head and neck cancer is alcohol use, particularly among liver transplant recipients who may have required their transplant because of alcohol use. Alcohol is an important risk factor for head and neck cancers—particularly, oropharynx cancers . Prior studies of liver transplant recipients have found increased risk of oropharynx cancer in patients with transplants related to alcohol use, but a lesser risk in patients without alcohol use .…”

Section: Discussionmentioning

confidence: 99%

“…Alcohol is an important risk factor for head and neck cancersparticularly, oropharynx cancers. 32 Prior studies of liver transplant recipients have found increased risk of oropharynx cancer in patients with transplants related to alcohol use, but a lesser risk in patients without alcohol use. 14,19,33 Unfortunately, in the present study, the reason for transplants (such as disease attributable to alcohol use) was not available in our dataset, though on multivariate analysis which included a limited assessment of alcohol use, oropharynx cancer remained significantly associated with prior solid organ transplant.…”

Section: Risk Of Head and Neck Cancer Following Solid Organ Transplantmentioning

confidence: 99%

Elevated incidence of head and neck cancer in solid organ transplant recipients

2019

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Background Solid organ transplant recipients are known to be at an increased risk of cancer development, but research on head and neck cancer in transplant recipients has been limited and prior risk assessments may not be accurate. Methods A retrospective review using a national Veterans Administration database to query outpatient problem lists for ICD codes indicating solid organ transplant and subsequent diagnosis of head and neck cancer. Results In a study of 30 939 656 patients (37 969 solid organ transplants and 113 995 head and neck cancers), history of transplant significantly predicted head and neck cancer, with relative risks ranging from 1.85 (thyroid) to 2.91 (salivary gland). Worse overall survival (OS) was seen for head and neck cancer patients with prior transplants. Conclusions In a large case‐control study, prior transplant was a risk factor for head and neck cancer development and worse OS for head and neck cancer patients.

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“…The cytoplasmic/nuclear expression of β-catenin in dysplastic and cancer cells was shown to be associated with its phosphorylation at tyrosine residues, which led to the release of β-catenin from complexes with E-cadherin [93]. It is widely recognized that the concurrent exposure to ethanol greatly potentiates the carcinogenic effects of tobacco chemicals [94]. It has been observed that the administration of 4-NQO increased the level of β-catenin in tongue epithelium, while the combined treatment with 4-NQO and ethanol additionally significantly decreased the inhibitory phosphorylation of β-catenin [95].…”

Section: The Role Of Hnscc Etiological Factors In Wnt/β-catenin Pathwmentioning

confidence: 99%

The Significance of the Dysregulation of Canonical Wnt Signaling in Head and Neck Squamous Cell Carcinomas

Paluszczak

2020

Cells

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The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options. Among the many molecular changes that are detected in head and neck cancer, the abnormalities in several signaling pathways, which regulate cell proliferation, cell death and stemness, seem to be especially promising with regard to the development of targeted therapies. Canonical Wnt signaling is a pathway engaged in the formation of head and neck tissues, however it is not active in adult somatic mucosal cells. The aim of this review paper is to bring together significant data related to the current knowledge on the mechanisms and functional significance of the dysregulation of the Wnt/β-catenin pathway in head and neck tumors. Research evidence related to the role of Wnt signaling activation in the stimulation of cell proliferation, migration and inhibition of apoptosis in HNSCC is presented. Moreover, its role in promoting stemness traits in head and neck cancer stem-like cells is described. Evidence corroborating the hypothesis that the Wnt signaling pathway is a very promising target of novel therapeutic interventions in HNSCC is also discussed.Cells 2020, 9, 723 2 of 20 blocking the interaction between PD-1 receptor and PD-L1, may be beneficial in patients with advanced, metastatic or recurrent HNSCC [7]. However, other therapeutic options are also necessary for the better clinical management of HNSCC patients. To that end, molecular alterations observed in HNSCC need to be studied in detail, in order to point to promising drug targets. Mechanisms of Wnt/β-Catenin Pathway Activation in HNSCCRecent genomic analyses have shown the prevalence of genetic driver alterations in HNSCC, which most frequently affect genes associated with receptor tyrosine kinase (e.g., EGFR, MET, KIT), PI3K, p53, Notch or Hippo signaling pathways. On the other hand, genetic alterations in genes related to canonical Wnt signaling were rarely detected in HNSCC [8,9]. In contrast to colorectal cancers, which show molecular alterations driving Wnt signaling activation in around 90% of cases [9], HNSCC were shown to lack CTNNB1 mutations and APC mutations were present infrequently [10][11][12][13][14][15][16]. The mutations of FAT1 tumor suppressor, which encodes a protocadherin protein that binds and inactivates β-catenin, were detected in some cases of HNSCC [17]. However, the activation of the Wnt/β-catenin pathway in HNSCC seems to be more prevalent than it is suggested by genetic findings, due to cross-talk with other molecular alterations, which can lead to pathway cross-activation. Indeed, it has been shown that β-catenin can be activated via enhanced EGFR or PI3K signaling, which belong to the most frequently dysregulated signaling pathways in HNSCC. In this regard, elevated EGFR expression was associated with delocalized β-catenin expression [13]. In another study, the nuclear ...

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Alcohol and head and neck cancer

Cited by 110 publications

References 95 publications

Cross-Cancer Evaluation of Polygenic Risk Scores for 17 Cancer Types in Two Large Cohorts

Cross-Cancer Evaluation of Polygenic Risk Scores for 17 Cancer Types in Two Large Cohorts

Elevated incidence of head and neck cancer in solid organ transplant recipients

The Significance of the Dysregulation of Canonical Wnt Signaling in Head and Neck Squamous Cell Carcinomas

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