Alchemilla viridiflora Rothm.: the potent natural inhibitor of angiotensin I-converting enzyme

Radović, Jelena; Suručić, Relja; Niketić, Marjan; Kundaković-Vasović, Tatjana

doi:10.1007/s11010-022-04410-7

Cited by 7 publications

(14 citation statements)

References 46 publications

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“…Pedunculagin, tellimagrandin I, tellimagrandin II and galloyl-bishexahydroxydiphenoyl (HHDP) hexose constituted the major ellagitannin fraction of A. viridiflora extract while flavonoid fraction comprised quercetin, quercetin derivates and kaempferol glycosides. The recent chemical characterization of A. viridiflora extract provided by Radovic et al (2022) is consistent with the present phytochemical analysis [16]. Pedunculagin is a significant monomeric ellagitannin commonly found in Alchemilla species that has been related to various biological activities such as antitumor, antioxidant, gastroprotective, hepatoprotective, and anti-inflammatory properties [18].…”

Section: Lc-ms Chemical Analysis (Phytochemical Analysis)supporting

confidence: 85%

“…Given that polyphenols are thought to be the primary bioactive chemicals in Alchemilla species, the polyphenolic profile has been thoroughly examined. According to our previous study conducted on the same extract, 23% of the polyphenolic components of A. viridiflora are present in the dry methanol extract [16]. Similarly, ellagitannins and flavonoids are two of the most abundant polyphenol classes in the sample used in this study.…”

Section: Lc-ms Chemical Analysis (Phytochemical Analysis)mentioning

confidence: 79%

“…Pedunculagin is a significant monomeric ellagitannin commonly found in Alchemilla species that has been related to various biological activities such as antitumor, antioxidant, gastroprotective, hepatoprotective, and anti-inflammatory properties [18]. Additionally, tellimagrandin I, a compound that was just recently identified as a constituent of Alchemilla species, and brevifolin carboxylic acid, an Alchemilla ellagitannin product of hydrolysis that is also typically found in various pomegranate parts, are both recognized for their bioactivity and significant antiviral activity [16,19,20]. Compounds from the flavonoid class are equally important in terms of biological function.…”

Section: Lc-ms Chemical Analysis (Phytochemical Analysis)mentioning

confidence: 99%

“…Tellimagrandin I and brevifolin carboxylic acid, two of the ellagitannins found in A. viridiflora, are frequently present in different pomegranate extracts. The significant potential A. viridiflora extract for inhibiting SARS-CoV-2 internalization via ACE2 receptors may be explained by these complementary ellagitannins and other compounds from the same class [16,30]. Additionally, it was discovered that urolithin A, a common ellagitannin metabolite in humans, is a potent inhibitor of SARS-CoV-2 binding to the ACE2 receptor [13].…”

Section: In Vitro Sars-cov-2 Internalization Inhibition Assaysmentioning

confidence: 99%

“…Recent investigations have revealed that Alchemilla viridiflora Rothm. (Figure 1) polar extract possessed a strong ACE inhibitory effect, with particular components, such as miquelianin, being emphasized for their individual contributions to this activity [16]. This could be yet another link between A. viridiflora constituents and SARS-CoV-2 given that the incidence of COVID-19 disease requiring hospital admission is significantly reduced while taking ACE inhibitors [17].…”

Section: Introductionmentioning

confidence: 99%

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In Silico and In Vitro Studies of Alchemilla viridiflora Rothm—Polyphenols’ Potential for Inhibition of SARS-CoV-2 Internalization

et al. 2022

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Since the outbreak of the COVID-19 pandemic, it has been obvious that virus infection poses a serious threat to human health on a global scale. Certain plants, particularly those rich in polyphenols, have been found to be effective antiviral agents. The effectiveness of Alchemilla viridiflora Rothm. (Rosaceae) methanol extract to prevent contact between virus spike (S)-glycoprotein and angiotensin-converting enzyme 2 (ACE2) and neuropilin-1 (NRP1) receptors was investigated. In vitro results revealed that the tested samples inhibited 50% of virus-receptor binding interactions in doses of 0.18 and 0.22 mg/mL for NRP1 and ACE2, respectively. Molecular docking studies revealed that the compounds from A. viridiflora ellagitannins class had a higher affinity for binding with S-glycoprotein whilst flavonoid compounds more significantly interacted with the NRP1 receptor. Quercetin 3-(6”-ferulylglucoside) and pentagalloylglucose were two compounds with the highest exhibited interfering potential for selected target receptors, with binding energies of −8.035 (S-glycoprotein) and −7.685 kcal/mol (NRP1), respectively. Furthermore, computational studies on other SARS-CoV-2 strains resulting from mutations in the original wild strain (V483A, N501Y-K417N-E484K, N501Y, N439K, L452R-T478K, K417N, G476S, F456L, E484K) revealed that virus internalization activity was maintained, but with different single compound contributions.

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Section: Lc-ms Chemical Analysis (Phytochemical Analysis)supporting

confidence: 85%

Section: Lc-ms Chemical Analysis (Phytochemical Analysis)mentioning

confidence: 79%

Section: Lc-ms Chemical Analysis (Phytochemical Analysis)mentioning

confidence: 99%

Section: In Vitro Sars-cov-2 Internalization Inhibition Assaysmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In Silico and In Vitro Studies of Alchemilla viridiflora Rothm—Polyphenols’ Potential for Inhibition of SARS-CoV-2 Internalization

et al. 2022

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Enzyme Inhibitory Activities, Phenolic Profile, and In Silico Studies of Sorbus torminalis Tree Bark Methanol Extract

Radović Selgrad,

Milutinović,

Suručić

et al. 2024

Chemistry & Biodiversity

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The different parts of Sorbus torminalis (L.) Crantz are used in traditional medicine for various conditions such as cardiac diseases, cough, and diabetes, indicating its significant medicinal potential. Therefore, the current investigation aimed to reveal the phenolic composition of the poorly studied S. torminalis methanol extract of the bark, as well as its capacity to inhibit enzymes relevant to cardiovascular, neurodegenerative, and metabolic diseases. A total of 28 phenolic components, including 20 procyanidins aglycones (A‐ and B‐type), four procyanidin glycosides, catechin and its glycoside, and two (epi)catechin derivatives, were detected using LC‐MS. The contents of total polyphenols (6.22%), total tannins (3.04%), condensed tannins (0.70%), and total flavonoids (0.24 %) were determined spectrophotometrically, highlighting the considerable phenolic richness of the examined plant material. The concentration‐dependent ability to inhibit α‐amylase (IC50=130 µg/mL), α‐glucosidase (IC50=312.13 µg/mL), acetylcholinesterase (IC50=156.46 µg/mL), butyrylcholinesterase (IC50=217.68 µg/mL), and angiotensin‐converting enzyme (IC50=36.77 µg/mL) was demonstrated. The in silico approach showed that catechin, procyanidin B2 and C1, S. torminalis bark constituents, can form stable complexes with the target enzymes but with different binding affinity. The results supported the medicinal potential of S. torminalis bark and significantly expanded our knowledge of its chemistry, justifying further research.

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Review from host and guest approach to new frontiers nutraceuticals in the era of COVID-19

Micucci,

Gioacchini,

Baggieri

et al. 2024

Future Foods

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Alchemilla viridiflora Rothm.: the potent natural inhibitor of angiotensin I-converting enzyme

Cited by 7 publications

References 46 publications

In Silico and In Vitro Studies of Alchemilla viridiflora Rothm—Polyphenols’ Potential for Inhibition of SARS-CoV-2 Internalization

In Silico and In Vitro Studies of Alchemilla viridiflora Rothm—Polyphenols’ Potential for Inhibition of SARS-CoV-2 Internalization

Enzyme Inhibitory Activities, Phenolic Profile, and In Silico Studies of Sorbus torminalis Tree Bark Methanol Extract

Review from host and guest approach to new frontiers nutraceuticals in the era of COVID-19

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