Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2012.01.070 View full text
Tiago C. Lourenço, João M. Batista Jr, Maysa Furlan, Yanan He, Laurence A. Nafie, Cesar C. Santana, Quezia B. Cass

Abstract: The enantiomeric separation of albendazole sulfoxide was carried out by simulated moving bed chromatography with variable zones (VARICOL). An overall recovery of 97% was achieved and enantiomeric ratios of 99.5% for raffinate and 99.0% for extract were attained. A total of 880 mg of (+)-albendazol sulfoxide and 930 mg of its antipode were collected after 55 cycles or 11 h of process, resulting in a mass rate of 2 g/day. Furthermore the absolute configuration of the enantiopure compounds was determined for the …

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