J. Neurosci. Res. volume 86, issue 7, P1511-1519 2008 DOI: 10.1002/jnr.21610 View full text
Yasuhiro Irino, Yasuko Nakamura, Kazuhide Inoue, Shinichi Kohsaka, Keiko Ohsawa

Abstract: Microglia play a variety of significant roles in the central nervous system (CNS), and in one of those roles they undergo morphological change in response to neural injury and migrate to the injured region. We previously reported that ATP/ADP promotes microglial chemotaxis via the Gi/o-coupled P2Y12 receptor; however, the intracellular signaling underlying P2Y12-receptor-mediated microglial chemotaxis is not fully understood. In this study, we examined the role of phospholipase C (PLC) and calcium signaling in…

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